Evaluation of <i>Achillea millefolium</i> essential oil compounds and biological effects on cervix cancer HeLa cell line

Acar, Mustafa Burak; İbiş, Ebru Karadaş; Şimşek, Ahmet; Vural, Cem; Tez, Coşkun; Özcan, Servet

doi:10.2478/ebtj-2020-0003

Cited by 8 publications

(8 citation statements)

References 16 publications

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“…These applications are mentioned in other traditional medicine as well (5), corroborated by experiments (6). Modern scientific investigations show that it possesses anti-inflammatory (7), antioxidant and antibacterial activities (8,9), as well as antican- Original scientific paper 124 cer properties (10). The aim of this investigation is to determine essential oil composition of A. millefolium sensu lato from Mt Rtanj and to develop a QSRR model for predicting the retention times of chemical compounds from the essential oil.…”

Section: Introductionmentioning

confidence: 99%

The quantitative structure-retention relationship of the GC-MS profile of yarrow essential oil

et al. 2021

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In the essential oil of yarrow (Achillea millefolium L. sensu lato) collected from natural population on Mt. Rtanj (Serbia) and distilled by Clevenger apparatus 104 compounds were detected, and the most abundant were camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8- cineole (5.6%). The quantitative structure-retention relationship (QSRR) model was employed to predict the retention indices, using four molecular descriptors selected by factor analysis and a genetic algorithm. The coefficients of determination reached the value of 0.862, demonstrating that this model could be used for prediction purposes.

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Section: Introductionmentioning

confidence: 99%

The quantitative structure-retention relationship of the GC-MS profile of yarrow essential oil

et al. 2021

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“…evaluated the effects of different concentrations of the essential oil of A. millefolium on HeLa (CCL‐2) cells. They reported that the essential oil had a high repressive effect on HeLa cells, decreased their proliferation, and prevented the increase in the number of cells [4] . It is noteworthy that the cytotoxic activity of A. millefolium was seen in previous studies, but we compared cytotoxic activity of A. millefolium essential oil in free, nano‐liposomal, and nano‐niosomal form.…”

Section: Resultsmentioning

confidence: 90%

“…They reported that the essential oil had a high repressive effect on HeLa cells, decreased their proliferation, and prevented the increase in the number of cells. [4] It is noteworthy that the cytotoxic activity of A. millefolium was seen in previous studies, but we compared cytotoxic activity of A. millefolium essential oil in free, nano-liposomal, and nano-niosomal form. In our study, there was a significant difference between the toxicity of encapsulated essential oil and free essential oil in terms of viability at concentrations of 15, 30, 60, 125, and 250 μg/ml (P < 0.05).…”

Section: Discussionmentioning

confidence: 90%

“…The most important compounds of this plant are polyphenol, flavonoid, lactone, betaine, acetylene, resin, and tannin [3] . Studies have shown the cytotoxic effect of essential oil of A. millefolium , A. clavennae , and A. alexandri‐regis against different malignant tumor cell lines [4–7] . The phytocompounds of Achillea genus may explain the anticancer activities of Achillea [8] .…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study of Nano‐liposome and Nano‐niosome for Delivery ofAchillea MillefoliumEssential Oils: Development, Optimization, Characterization and Their Cytotoxicity Effects on Cancer Cell Lines and Antibacterial Activity

Emtiazi

Sharif

Hemati

et al. 2022

Chemistry & Biodiversity

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Nanoencapsulation of essential oils (EOs) in drug delivery systems leads to their capability of improving their solubility, stability, and bioavailability of them. The aim of this study was preparation, optimization, and characterization of nano-liposomes/nano-niosomes containing Achillea millefolium essential oils (A. millefolium EOs) and comparison of their properties. In the experimental study, characteristics of nanoparticles including size, zeta potential, Fourier Transform Infrared Spectroscopy (FTIR), % encapsulation efficiency (EE%) and the release amount of essential oils from nano-liposome or niosome were assessed using different techniques. Then to determine cell viability at different concentrations, the MTT assay was used. Also, the dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of antimicrobial agents. The optimized formulations provided potential advantages, including an appropriate nano-size scale, and a negative charge, and also showed a continuous drug release behavior, which successfully encapsulated essential oil with high entrapment efficiency. In terms of size and release amount, nano-niosome had superiority to nano-liposome with smaller size and also slower release but nano-liposome could encapsulate essential oils in a higher percentage compared to nano-niosome. Also, there was a significant difference between the toxicity of encapsulated EOs and free EOs in terms of viability (P < 0.05). In addition, the antimicrobial effect of liposomal and niosomal EO was greater than free EO. In conclusion, the designed nano-based systems were determined as promising lipid-based nano-carriers for essential oil delivery that proffered a novel, high potential therapy for breast cancer and favorable antimicrobial effects.

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“…Achillea millefolium L. (AM) belongs to the Asteraceae family and it is prescribed as a complementary and alternative therapy for many diseases, including cancer, cystitis, diabetes mellitus, for example (MB et al., 2020). AM is a potential therapeutic agent because of its many different chemical constituents such as flavonoids, phenols, alkamides, coumarins, terpenoids, sterols and glucoside.…”

Section: Introductionmentioning

confidence: 99%

Achillea millefolium alleviates testicular damage in paclitaxel‐intoxicated rats via attenuation of testicular oxido‐inflammatory stress and apoptotic responses

Okkay

Çiçek

et al. 2021

Andrologia

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The aim of this study was to investigate the effects of Achillea millefolium extract in paclitaxel‐induced testicular toxicity in rats. The groups were designed as (1) control, (2) paclitaxel (8 mg/kg, intraperitoneally), (3) paclitaxel (8 mg/kg, intraperitoneally) + Achillea millefolium (200 mg/kg, orally for 14 consecutive days) and (4) paclitaxel (8 mg/kg, intraperitoneally) + Achillea millefolium (400 mg/kg, orally for 14 consecutive days). Serum levels of testosterone, luteinising hormone and follicle‐stimulating hormone, as well as total antioxidant capacity and total oxidant status were measured one day after receiving the last dose of Achillea millefolium extract. Testicular superoxide dismutase activity, malondialdehyde, tumour necrosis factor alpha and interleukin‐1β levels, the expressions of nuclear factor kappa B and caspase‐3 were evaluated. In addition, testicular sections were evaluated histopathologically and 8‐hydroxy‐2′‐deoxyguanosine was detected immunohistochemically. Achillea millefolium improved the levels of luteinising hormone, follicle‐stimulating hormone and testosterone, upregulated testicular antioxidant enzymes and downregulated inflammation. Furthermore, we observed that Achillea millefolium restored testicular histopathological structure and significantly suppressed oxidative DNA damage and apoptosis by reducing the expression of caspase‐3. Taken together, our results suggest that Achillea millefolium has protective effects against paclitaxel‐induced testicular toxicity and is a promising natural product with the potential to improve male fertility.

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Evaluation of Achillea millefolium essential oil compounds and biological effects on cervix cancer HeLa cell line

Cited by 8 publications

References 16 publications

The quantitative structure-retention relationship of the GC-MS profile of yarrow essential oil

The quantitative structure-retention relationship of the GC-MS profile of yarrow essential oil

Comparative Study of Nano‐liposome and Nano‐niosome for Delivery ofAchillea MillefoliumEssential Oils: Development, Optimization, Characterization and Their Cytotoxicity Effects on Cancer Cell Lines and Antibacterial Activity

Achillea millefolium alleviates testicular damage in paclitaxel‐intoxicated rats via attenuation of testicular oxido‐inflammatory stress and apoptotic responses

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