Evaluation of “<i>Helicobacter heilmannii</i>” Subtypes in the Gastric Mucosas of Cats and Dogs

Priestnall, Simon L.; Wiinberg, Bo; Spohr, Anette; Neuhaus, Britta; M, Kuffer; Wiedmann, Martin; Simpson, Kenneth W.

doi:10.1128/jcm.42.5.2144-2151.2004

Cited by 74 publications

(71 citation statements)

References 31 publications

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“…In humans, oral-oral, fecal-oral and gastro-oral routes of transmission are suspected, while the oral cavity is thought to serve as the reservoir of the bacteria (Agüloǧlu et al 2006, Cellini et al 2010, Abdel-Raouf et al 2014. Other species of Helicobacter may be the cause of gastritis in 0.25 -4% of humans (Priestnall et al 2004). Therefore, it is thought that dogs and cats are risk factors of a Helicobacter spp.…”

Section: Discussionmentioning

confidence: 99%

“…Studies assessing the prevalence of various species of Helicobacter in the canine stomach seem to confirm this finding. The most common species identified in Finland, the United States and Belgium is Helicobacter bizzozeronii (Jalava et al 1997, Priestnall et al 2004, Bulck et al 2005. Helicobacter salomonis is the most commonly found species in Sweden (Ekman et al 2013), while Helicobacter heilmannii is the most recognized species in Poland, Portugal and South Korea (Hwang et al 2002, Kubiak 2006, Amorim et al 2015.…”

Section: Discussionmentioning

confidence: 99%

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Detection of Helicobacter spp. in the saliva of dogs with gastritis

Jankowski¹,

Spużak²,

Kubiak³

et al. 2016

Polish Journal of Veterinary Sciences

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The aim of this study was to identify the species and determine the prevalence of gastric Helicobacter in the saliva of dogs with gastritis. The study was carried out on 30 dogs of different breeds, genders and ages, which were diagnosed with gastritis. The nested-PCR method was used to detect Helicobacter spp. in saliva. Helicobacter bacteria were found in the saliva samples of 23 (76.6%) dogs. Helicobacter heilmannii was the most commonly detected species of gastric Helicobacter spp. in canine saliva, and was found in 22 (73.3%) cases. The results indicate that gastric Helicobacter spp. occurs relatively frequently in dogs with gastritis. Moreover, the saliva of dogs with gastritis may be a source of Helicobacter spp. infection for humans and other animals. However, further studies are needed to confirm this finding as the PCR method does not distinguish active from inactive infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection of Helicobacter spp. in the saliva of dogs with gastritis

Jankowski¹,

Spużak²,

Kubiak³

et al. 2016

Polish Journal of Veterinary Sciences

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“…An early study used several detection techniques and showed that the stomach of 91% of pet cats (n=58) were positive for the genus Helicobacter (Neiger et al 1998), suggesting a high occurrence of this bacterial group in the feline stomach. In another study, it was shown that cats and dogs are predominantly coloniszed by H. heilmannii (Priestnall et al 2004) but other species (e.g., H. felis, H. bizzozeronii, H. salomonis, H. pametensis) have also been identified in these animal species (Neiger and Simpson 2000).…”

Section: The Gi Microbiota Of Catsmentioning

confidence: 99%

Gastrointestinal microorganisms in cats and dogs: a brief review

Garcia-Mazcorro¹,

Minamoto

2013

Arch. med. vet.

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RESUMENEl tracto gastrointestinal (GI) de animales contiene diferentes tipos de microorganismos conocido como la microbiota GI. Por mucho tiempo, la microbiota GI ha generado interés porque los microorganismos GI están involucrados en múltiples procesos fisiológicos en el hospedero, así perpetuando salud o enfermedad. Estudios recientes han demostrado que la microbiota GI de gatos y perros es tan compleja como en humanos y otros animales, revelado con el uso de tecnologías de secuencia modernas y otras técnicas moleculares. La microbiota GI incluye miembros de todos los tres dominios principales de vida (Archaea, Bacterias y Eucariotas), pero las bacterias son el grupo de microorganismos más abundante y metabólicamente activo. El estómago de gatos y perros esta principalmente poblado de Helicobacter spp., el cual en perros puede representar tanto como el 98% de toda la microbiota bacteriana en el estómago. El intestino delgado contiene una microbiota más diversa, conteniendo representantes de al menos cinco diferentes filos bacterianos (principalmente Firmicutes y Bacteroidetes). El intestino grueso contiene el grupo de bacterias más abundante (~10 11 células bacterianas por gramo de contenido intestinal), diverso (al menos diez diferentes filos han sido detectados) y metabólicamente relevante en el tracto GI. La mayoría de las bacterias en el intestino grueso son anaerobios estrictos, los cuales dependen de la fermentación de sustancias no digeridas para subsistir. Aunque estudios recientes han dilucidado las complejidades de la microbiota GI en gatos y perros, más investigación todavía es necesaria para encontrar maneras de manipular exitosamente los microorganismos GI para prevenir y/o tratar enfermedades GI.Palabras clave: gastrointestinal, microbiota, gatos, perros. SUMMARYThe gastrointestinal (GI) tract of animals contains different types of microorganisms known as the GI microbiota. The GI microbiota has long been of interest because of its involvement in multiple physiological processes in the host, influencing health or disease. Recent studies have shown that the GI microbiota of cats and dogs is as complex as the one present in humans and other animals, according to state-of-the-art sequencing technologies and other molecular techniques. The GI microbiota includes members of all three main life domains (Archaea, Bacteria, and Eukaryotes), with bacteria being the most abundant and metabolically active group of microorganisms. The stomach of cats and dogs is mainly inhabited by Helicobacter spp., which in dogs may account for as much as 98% of all gastric bacterial microbiota. The small intestine harbors a more diverse microbiota as it contains representatives from at least five bacterial phyla (mainly Firmicutes and Bacteroidetes). The large intestine harbors the most abundant (~10 11 bacterial cells per gram of intestinal content), diverse (at least 10 bacterial phyla have been identified) and physiologically relevant group of bacteria in the GI tract. Most bacteria in the large intestine are strict an...

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“…Currently, the most accurate method available for conclusive species identification is the use of PCR, followed by sequencing of specific target genes. These include the urease A and B (ureA, ureB) genes, the heat shock protein 60 (hsp60) gene, and the gyrase subunit B (gyrB) gene [44,[71][72][73][74] . Sequencing of the 16S rRNA gene and of the 23S rRNA gene allows distinction of H. suis from the rest of the H. heilmannii s.l.…”

Section: Diagnosismentioning

confidence: 99%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. Core tip: Helicobacter heilmannii sensu lato is a group of non-Helicobacter pylori Helicobacter species that infect the stomach of animals and humans. In the human stomach, these infections are associated with several pathologies, but it is currently unknown whether certain species are more often associated with a certain disease outcome than others. The access to bacterial genomes together with the availability of increasing numbers of in vitro isolates will allow significant advances in the understanding of species-specific bacteria-host interactions in disease pathogenesis and will be essential for future development of strategies to prevent and treat these infections.

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Evaluation of “Helicobacter heilmannii” Subtypes in the Gastric Mucosas of Cats and Dogs

Cited by 74 publications

References 31 publications

Detection of Helicobacter spp. in the saliva of dogs with gastritis

Detection of Helicobacter spp. in the saliva of dogs with gastritis

Gastrointestinal microorganisms in cats and dogs: a brief review

Helicobacter heilmannii sensu lato: An overview of the infection in humans

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