Evaluation of <i>in vitro</i> cytotoxicity of superparamagnetic poly(thioether-ester) nanoparticles on erythrocytes, non-tumor (NIH3T3), tumor (HeLa) cells and hyperthermia studies

Santos, Paula Christina Mattos dos; Feuser, Paulo Emílio; Cardoso, Priscilla B.; Steiner, Bethina T.; Córneo, Emily; Scussel, Rahisa; Viegas, A.D.C.; Machado-de-Ávila, Ricardo Andrez; Sayer, Cláudia; Araújo, Pedro Henrique Hermes de

doi:10.1080/09205063.2018.1564134

Cited by 16 publications

(7 citation statements)

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“…As shown in previous works, this amount of MNPs, as well as, the Ms value are sufficient to be easily guided by the action of an external magnetic field gradient and to promote a hyperthermic effect on the cells. [8,26,43] Figure 6 shows that the PMMA-MNPs-CO did not present cytotoxic effect when exposed on fibroblast cells in all tested MNPs concentrations.…”

Section: Resultsmentioning

confidence: 97%

“…The reduction of saturation magnetization of MNPs after polymeric encapsulation has already been reported in the literature. Santos et al (2018), [8] Prabha and Raj (2016), [45] and Batch et al (2012) [46] observed a reduction of 50%, 41%, and 49% in the saturation magnetization of MNPs after encapsulation in poly(thioether-ester), chitosan and, PMMA NPs, respectively. The superparamagnetic profile is es- sential for MNPs to exert hyperthermic effects and to be directed to specific targets.…”

Section: Resultsmentioning

confidence: 98%

“…[6,7] These characteristics of MNPs makes it a great potential alternative to decrease drug dosage administration. [8,9] DOI: 10.1002/masy.202000112…”

Section: Introductionmentioning

confidence: 99%

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Encapsulation of Magnetic Nanoparticles and Copaíba Oil in Poly(methyl methacrylate) Nanoparticles via Miniemulsion Polymerization for Biomedical Application

Cordeiro

Feuser

Araújo

et al. 2020

Macromolecular Symposia

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Polymeric nanoparticles (NPs) are used for drug delivery, mainly due to their ability to increase the selectivity and therapeutic efficacy of the encapsulated molecules. Alternative therapeutic compounds like magnetic nanoparticles (MNPs) and copaiba oil are alternatives for the development of more efficient and less aggressive therapeutic systems. The objective of the present work is to synthesize poly(methyl methacrylate) (PMMA) nanoparticles containing MNPs and copaiba oil (CO) via miniemulsion polymerization. The nanoparticles presented a mean diameter of ≈98 ± 1 nm with narrow particle size dispersion (0.1) and high colloidal stability with zeta potential below −50 ± −3 mV. The miniemulsion polymerization process allowed to incorporate the MNPs and the copaiba oil into the polymer matrix and the nanoparticles presented a saturation magnetization higher than ≈49 emu/g of MNPs and superparamagnetic properties. The evaluated PMMA‐MNPs‐CO concentrations, up to 200 µg mL−1 of MNPs, did not affect fibroblast cells viability.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 98%

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Encapsulation of Magnetic Nanoparticles and Copaíba Oil in Poly(methyl methacrylate) Nanoparticles via Miniemulsion Polymerization for Biomedical Application

Cordeiro

Feuser

Araújo

et al. 2020

Macromolecular Symposia

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“…Thus, MNPs were successfully incorporated during PTE NP formation by miniemulsion forming MNP–PTE NPs with diameters around 150 nm and exhibiting superparamagnetic behaviour for magnetic hyperthermia therapies. 45…”

Section: Ros-sensitive Thioether-containing Polymersmentioning

confidence: 99%

Thioether-based ROS responsive polymers for biomedical applications

Criado‐Gonzalez

Mecerreyes

2022

J. Mater. Chem. B

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“…They show remarkable behavior when compared with single‐component particle given they can display combined properties of both the core and the shell materials, which is particularly interesting for the medical field (Vasudevan, Gaddam, Trinchi, & Cole, ). Traditionally, several oxides have been researched for possible application in hyperthermia treatment (Mattos dos Santos et al, ). In such area, prospective nanoparticles (NPs) must combine properties of high magnetic saturation, superparamagnetic character and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Novel core‐shell nanocomposites based on TiO₂‐covered magnetic Co₃O₄ for biomedical applications

et al. 2019

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Magnetic Co 3 O 4 nanoparticles (NPs) have great potential for applications in biomedicine, as contrast enhancement agents for magnetic resonance imaging, or for drug delivery. Although these NPs are so attractive, their potential toxicity raises serious questions about decreasing cellular viability. In this context, Co 3 O 4 NPs were prepared via sol-gel method and encapsulated with a layer of TiO 2 , a biocompatible oxide, and subjected to structural, magnetic and toxicity characterization. X-ray diffractograms of the samples demonstrate the successful synthesis of the spinel and Raman spectroscopy confirms the coating of the Co 3 O 4 spinel with TiO 2 . The Co 3 O 4 cores showed a very intense superparamagnetic character; however, this behavior is strongly suppressed when the material is covered with TiO 2 . According to the neutral red uptake assay, the coating of the cores with TiO 2 significantly decreases the cytotoxic character of the Co 3 O 4 particles and, as it can be observed with the zeta (ξ) potential measurements, they form a stable colloidal dispersion at cytoplasmic pH. The effect of the thermal treatment enhances the biocompatibility even further, with no statistically significant effect on cell viability even at the highest analyzed concentration. The proposed pathway presents a successful sol-gel method for the preparation of Co 3 O 4 @TiO 2 core-shell nanoparticles. This work opens up possibilities for future application of these materials not only for magnetic resonance imaging but also in catalysis and hyperthermia.

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Evaluation of in vitro cytotoxicity of superparamagnetic poly(thioether-ester) nanoparticles on erythrocytes, non-tumor (NIH3T3), tumor (HeLa) cells and hyperthermia studies

Cited by 16 publications

References 60 publications

Encapsulation of Magnetic Nanoparticles and Copaíba Oil in Poly(methyl methacrylate) Nanoparticles via Miniemulsion Polymerization for Biomedical Application

Encapsulation of Magnetic Nanoparticles and Copaíba Oil in Poly(methyl methacrylate) Nanoparticles via Miniemulsion Polymerization for Biomedical Application

Thioether-based ROS responsive polymers for biomedical applications

Novel core‐shell nanocomposites based on TiO₂‐covered magnetic Co₃O₄ for biomedical applications

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Evaluation of in vitro cytotoxicity of superparamagnetic poly(thioether-ester) nanoparticles on erythrocytes, non-tumor (NIH3T3), tumor (HeLa) cells and hyperthermia studies

Cited by 16 publications

References 60 publications

Encapsulation of Magnetic Nanoparticles and Copaíba Oil in Poly(methyl methacrylate) Nanoparticles via Miniemulsion Polymerization for Biomedical Application

Encapsulation of Magnetic Nanoparticles and Copaíba Oil in Poly(methyl methacrylate) Nanoparticles via Miniemulsion Polymerization for Biomedical Application

Thioether-based ROS responsive polymers for biomedical applications

Novel core‐shell nanocomposites based on TiO2‐covered magnetic Co3O4 for biomedical applications

Contact Info

Product

Resources

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Novel core‐shell nanocomposites based on TiO₂‐covered magnetic Co₃O₄ for biomedical applications