Evaluation of <i>In vivo</i> Wound Healing Activity of dried leaf Ethanolic extract of <i>Indigofera tinctoria</i> on Albino Wistar Rat

Manimekalai, P.; Gurumoorthy, M.; Dhanalakshmi, Ravikumar

doi:10.5958/0974-360x.2019.00143.4

Cited by 6 publications

(2 citation statements)

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“…Second-degree burn has been the focus of clinical treatment, especially the deep second-degree burn. Patients who suffer from deep second-degree burn have obvious tissue necrosis on the wound and wound exudation and are susceptible to infection [ 21 – 23 ]. The main reason affecting the wound healing of the second-degree burn is that the early vascular stasis band turns into a coagulation necrosis band under the impact of bacterial infection, which subsequently leads to the necrosis of the parabiosis tissue, resulting in delayed wound healing and aggravated scar hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Curative Effect Observation of Applying Silver-Zinc Bacteriostatic Cream to Patients with Second-Degree Burn under Targeted Nursing Intervention and Its Effect on Wound Healing Rate

Liu

2021

Journal of Healthcare Engineering

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Second-degree burn is the most common type of burn wound in the clinics, which presents a deeper wound, skin blisters, white or red bottom, and thick and clear fluid inside, is sensitive to tenderness, and turns white by compression [1, 2]. The aim of this study is to explore the efficacy of applying silver-zinc bacteriostatic cream to patients with second-degree burn under targeted nursing intervention and its effect on wound healing rate. A total of 110 patients with second-degree burn treated in our hospital from January 2019 to June 2021 were selected as the research object for the retrospective study. Between the experimental group and the control group, no statistical differences in patients’ general information were observed ( P > 0.05 ); 1 week, 2 weeks, and 3 weeks after treatment, the visual analogue scale (VAS) pain scores of the experimental group were significantly lower ( P < 0.05 ); and the total incidence rate of adverse reactions was remarkably lower in the experimental group ( P < 0.05 ). On the basis of targeted nursing intervention, applying silver-zinc bacteriostatic cream obtains an obviously better clinical efficacy than silver sulfadiazine ointment in treating second-degree burn and works better in promoting wound healing, relieving pain sensation, and reducing adverse reactions.

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Section: Discussionmentioning

confidence: 99%

Curative Effect Observation of Applying Silver-Zinc Bacteriostatic Cream to Patients with Second-Degree Burn under Targeted Nursing Intervention and Its Effect on Wound Healing Rate

Liu

2021

Journal of Healthcare Engineering

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“…Amino acid may accelerate the healing procedure by hastening the proliferation of the cell. Amino acid also help to reinforce the maturation of eschar.Flavonoids may play an important role in the processes that contribute to faster wound healing[23]. The eicosanoid biosynthesis used to inhibit by the endogenous antioxidants, stimulated by flavonoids.…”

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confidence: 99%

Preclinical Evaluation of Marsilea Quadrifolia Leaves for Its Wound Healing Activity

2024

IJBPAS

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Marsilea quadrifolia is widely used for the treatment of varieties of skin diseases in the Ayurvedic medicine system, as well as it is also used as folk medicine in wound management. But still there was no scientific data available on wound healing activity of Marsilea quadrifolia . So, we had attempted to investigate this activity. The purpose of this study was to screen the wound healing properties of a hydro-alcoholic extract of Marsilea quadrifolia leaves. In this research study, the hydroalcoholic extract of Marsilea quadrifolia leaves was obtained by percolation method. Two doses of Marsilea quadrifolia (2.5% and 5%) suitable gel formulation was prepared with the help of HPMC as a gel base to apply topically. Evaluation of the wound healing activity was done by "Excision, and Incision wound" models, also we performed skin irritation study. In the excision wound model, rats treated with Marsilea quadrifolia leaves extract showed a significant improvement in the epithelization time and 50%wound contraction. As well as, the breaking strength of rats treated with Marsilea quadrifolia leaves extract increased significantly in an incision wound model as compared to the control group.Marsilea quadrifolia leaves extract gel formulations shown likely similar activities as compared to synthetic standard/marketed povidone-iodine as well as herbal standard Aloe vera gel formulation.Marsilea quadrifolia does not produce any irritation in the skin So, it can be concluded that Marsilea quadrifolia leaves extract (2.5 % and 5% gel formulation) has potent wound healing activity.

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Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice

Munireddy

Venkatachalam

Thangavelu

2021

RJPT

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The main aim of the study was to evaluate the chemopreventive potential of Kayan Karpam (KK) against Benzo(a) Pyrene (B(a)P) induced lung carcinogenesis in experimental mice. In this study, we evaluated the impact of KK as an effective antioxidant and anticarcinogenic agent against B(a)P, a possible carcinogen present in cigarette smoke. All mice were randomly assorted into five groups. Group I mice served as control (Control), group II mice were received KK at the dosage of 250mg/kg b.wt. for 16 weeks. Groups III-VI received B(a)P at the dosage of 50mg/kg b.wt. weekly twice orally for the first 4 weeks. Further, along with B(a)P, group IV received KK, as like group 2 for 16 weeks, group V mice received B(a)P, as like groups 3 and 4, along with KK starting from the 9th week of the experimental period. We observed, that carcinogen induced mice treated with different treatment regimens of KK showed a potent chemopreventive action. Significant (P<0.05) increases in cellular enzymatic antioxidants such as SOD, CAT and GPx and levels of non-enzymatic antioxidants like GSH, vitamins E and C were noted in KK treated mice. Highly significant reductions were observed in the levels of lipid peroxidative by products and lung cancer marker enzymes like AHH, ᵧ-GT, 5’-ND and LDH in the mice administered with KK. Supplementation with KK to tumor bearing mice normalized the expression patterns of pro- and anti- apoptotic proteins (p21, Bax, Bcl-2), modulated NF-κB, and reduced the levels of COX-2. These findings further suggest the view that the Indian medicinal plants present in KK are promising sources of potential drugs against lung cancer.

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Evaluation of In vivo Wound Healing Activity of dried leaf Ethanolic extract of Indigofera tinctoria on Albino Wistar Rat

Cited by 6 publications

References 0 publications

Curative Effect Observation of Applying Silver-Zinc Bacteriostatic Cream to Patients with Second-Degree Burn under Targeted Nursing Intervention and Its Effect on Wound Healing Rate

Curative Effect Observation of Applying Silver-Zinc Bacteriostatic Cream to Patients with Second-Degree Burn under Targeted Nursing Intervention and Its Effect on Wound Healing Rate

Preclinical Evaluation of Marsilea Quadrifolia Leaves for Its Wound Healing Activity

Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice

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