2020
DOI: 10.1101/2020.08.26.20182287
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Evaluation of indirect damage and damage saturation effects in dose-response curves of hypofractionated radiotherapy of early-stage NSCLC and brain metastases

Abstract: Background: In this work we aim to investigate the possible contribution of indirect damage and damage saturation to tumor control probabilities (TCP) obtained with SBRT/SRS treatments for early-stage NSCLC and brain metastases. Methods: We have constructed a dataset of early-stage NSCLC and brain metastases response to different fractionations. Dose-response curves were fitted to models based on the linear-quadratic (LQ), the linear-quadratic-linear (LQL), and phenomenological modifications of the LQ model to… Show more

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“…Information about each treatment schedule is summarised in Tables SM1 and SM2. Further information is provided in a datasheet available from [33].…”
Section: Clinical Datasetmentioning
confidence: 99%
“…Information about each treatment schedule is summarised in Tables SM1 and SM2. Further information is provided in a datasheet available from [33].…”
Section: Clinical Datasetmentioning
confidence: 99%