Evaluation of IGFBP5 expression and plasma osteopontin level in COVID-19 patients

Uzunçakmak, Sevgi Karabulut; Aksakal, Alperen; Kerget, Ferhan; Aydin, Pelin; Halıcı, Zekai

doi:10.1016/j.advms.2022.11.001

Cited by 6 publications

(8 citation statements)

References 27 publications

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“…Studies have shown that there are changes in the expressions of molecules that are components of many mechanisms in COVID-19 infection. 2 , 28 As there are molecules with increased expression, the number of molecules with decreased expression is also quite high. 77 It is also conceivable that the common points here are symptoms rather than molecules.…”

Section: Discussionmentioning

confidence: 99%

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SARS-CoV-2 Infection and Candidate Biomarkers

Uzunçakmak¹

2023

Eurasian J Med

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Severe acute respiratory syndrome coronavirus 2 is a virus that can still infect individuals and whose deadly effects continue despite the current vaccines and drugs. Since 2019, many studies on the pathogenesis of the disease have been completed and continue to be done. In addition to the diagnosis and treatment of the disease, many molecules that can be markers of the disease have been investigated. In the early stages of the pandemic, many nonspecific and infection-related laboratory findings and chest computed tomography were used to obtain information about the diagnosis of the disease. The more individual molecules became associated with the disease yet. The purpose of this review is to summarize the impact and role of many molecules associated with coronavirus disease-2019 infection that have been previously used and newly revealed. Numerous studies are summarized in this review. The obtained data show that previously used laboratory findings and new potential biomarkers are not specific to the disease. New potential biomarkers have been associated with the severity of the disease itself, as can be seen with lung imaging and even with routine laboratory findings. One of the important points that are seen frequently in studies is that the effectiveness of these molecules has been shown not only in coronavirus disease-2019 infection but also in many other diseases. This removes the pathogenesis of the disease from being a unique mechanism created by the Severe acute respiratory syndrome coronavirus 2 and provides a general perspective formed by viral or bacterial infections. However, there are still many molecular changes that need to be investigated. Future studies will continue to update themselves with the mutations of the virus.

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Section: Discussionmentioning

confidence: 99%

“…Numerous studies conducted for this purpose have revealed that many molecules that may be specific to the disease change with it. 28 Numerous potential biomarkers in different categories that may be associated with COVID-19 infection from different studies and their functions are summarized below.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Infection and Candidate Biomarkers

Uzunçakmak¹

2023

Eurasian J Med

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“…Persistently increased concentrations of OPN in serum are related to an unfavorable outcome in critically ill patients [ 140 ]. Thus, COVID-19 patients with critical illness demonstrate higher OPN levels than non-critically ill patients [ 141 ]. OPN is associated with adverse clinical outcomes and disease mortality in COVID-19 [ 142 ].…”

Section: Immunoregulatory Roles Of Opn In Diseasesmentioning

confidence: 99%

Immunoregulatory Roles of Osteopontin in Diseases

Wang,

Niu

2024

Nutrients

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Osteopontin (OPN) is a multifunctional protein that plays a pivotal role in the immune system. It is involved in various biological processes, including cell adhesion, migration and survival. The study of the immunomodulatory effects of OPN is of paramount importance due to its potential therapeutic applications. A comprehensive understanding of how OPN regulates the immune response could pave the way for the development of novel treatments for a multitude of diseases, including autoimmune disorders, infectious diseases and cancer. Therefore, in the following paper, we provide a systematic overview of OPN and its immunoregulatory roles in various diseases, laying the foundation for the development of OPN-based therapies in the future.

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“…Ongoing bacterial and viral infections trigger OPN release and the subsequent Th1 responses, finally resulting in a vicious cycle which perpetuates inflammation. For these reasons, it has already been used as a non-specific marker to monitor the progression of various diseases and to predict a negative outcome in specific conditions, such as sepsis and aneurysmal subarachnoid hemorrhage [ 171 , 178 , 179 , 180 , 181 , 182 ].…”

Section: Proposed Biomarkers Not Yet Implemented In Clinical Practicementioning

confidence: 99%

“…To date, it is well established that SARS-CoV-2-induced pneumonia depends on the impairment of monocytes’ metabolism and functions [ 183 , 184 ], and, according to such evidence, several studies have highlighted a direct relationship between increased OPN levels and the severe clinical evolution of SARS-CoV-2-infected patients [ 171 , 174 , 176 , 179 , 185 ]. Moreover, OPN is also correlated with lung fibrotic evolution [ 186 , 187 , 188 ]; Karabulut Uzunçakmak and coworkers demonstrated that OPN levels are directly associated not only with COVID-19 severity, but also with the development of pulmonary fibrosis, a condition usually observed in the most critical patients [ 179 ]. This evidence supports the implementation of OPN evaluation during triage procedures in SARS-CoV-2-positive patients.…”

Section: Proposed Biomarkers Not Yet Implemented In Clinical Practicementioning

confidence: 99%

COVID-19 Biomarkers at the Crossroad between Patient Stratification and Targeted Therapy: The Role of Validated and Proposed Parameters

Rizzi

D’Onghia

Tonello

et al. 2023

IJMS

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Clinical knowledge about SARS-CoV-2 infection mechanisms and COVID-19 pathophysiology have enormously increased during the pandemic. Nevertheless, because of the great heterogeneity of disease manifestations, a precise patient stratification at admission is still difficult, thus rendering a rational allocation of limited medical resources as well as a tailored therapeutic approach challenging. To date, many hematologic biomarkers have been validated to support the early triage of SARS-CoV-2-positive patients and to monitor their disease progression. Among them, some indices have proven to be not only predictive parameters, but also direct or indirect pharmacological targets, thus allowing for a more tailored approach to single-patient symptoms, especially in those with severe progressive disease. While many blood test-derived parameters quickly entered routine clinical practice, other circulating biomarkers have been proposed by several researchers who have investigated their reliability in specific patient cohorts. Despite their usefulness in specific contexts as well as their potential interest as therapeutic targets, such experimental markers have not been implemented in routine clinical practice, mainly due to their higher costs and low availability in general hospital settings. This narrative review will present an overview of the most commonly adopted biomarkers in clinical practice and of the most promising ones emerging from specific population studies. Considering that each of the validated markers reflects a specific aspect of COVID-19 evolution, embedding new highly informative markers into routine clinical testing could help not only in early patient stratification, but also in guiding a timely and tailored method of therapeutic intervention.

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Evaluation of IGFBP5 expression and plasma osteopontin level in COVID-19 patients

Cited by 6 publications

References 27 publications

SARS-CoV-2 Infection and Candidate Biomarkers

SARS-CoV-2 Infection and Candidate Biomarkers

Immunoregulatory Roles of Osteopontin in Diseases

COVID-19 Biomarkers at the Crossroad between Patient Stratification and Targeted Therapy: The Role of Validated and Proposed Parameters

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