Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil

Relação entre Periodontite, Polimorfismos Genéticos e Doença Arterial Coronariana no Sul do Brasil

“…20 Similarly, Brazilian authors analyzed 200 patients with acute coronary syndrome and their association with the presence of the IL6 -174 G > C polymorphism in Pernambuco, Brazil, and found no significant association between the presence of the risk alleles and acute coronary syndrome. 27 The variables that were significant were included in a bivariate logistic regression model with the purpose of adjusting the independence of these associations, verifying which of them would predict CAD. The most uniform model was the one that remained independently associated with CAD, age > 60 years and the presence of the +1444 C > T PCR polymorphism (table 2).…”

Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease

“…Overall, a total of 35 out of 1158 articles were selected for the final meta-analysis. Among the 35 articles, 18 studies [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] 1158 studies were correlated with Search words 'G308A' or'TNF-α' or'C174G'or'IL-6'or'coronary atherosclerotic heart disease' 903 articles were excluded after reading the title and abstract;612 were not case-control studies;The genes studied in 291 papers were not related to this study. 255 articles were read in full 152 were not subject to coronary atherosclerotic heart disease;68 did not examine the number of specific genotypes.…”