Evaluation of image quality and radiation dose using gold nanoparticles and other clinical contrast agents in dual-energy Computed Tomography (CT): CT abdomen phantom

Zukhi, Jihan; Yusob, D.; Tajuddin, A.A.; Lim, Vuanghao; Zainon, Rafidah

doi:10.1088/1742-6596/851/1/012008

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Gold nanoparticles (AuNPs) are extensively studied in several applications from material to medical science 10 – 13 due to some unique qualities 14 , 15 ; such as nontoxic, easy availability with controlled size and shape 6 , higher particle reactivity, surface modification capability, as well as high optical qualities 16 . As a result of the localized surface plasmon resonance (LSPR), gold nanoparticles demonstrate a red or purple colour nearly around a wavelength of 530 nm 11 , 12 . The properties of AuNPs can be modified by controlling their size, shape, and surface modification via synthetic processes.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of gold nanoparticles in Gum Arabic using pulsed laser ablation for CT imaging

Mzwd

Ahmed

Suradi

et al. 2022

Sci Rep

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Laser ablation synthesis in liquid solution (PLAL) is a green technique that allows for the physical formation of nanomaterials. This study indicates the preparation of stable gold nanoparticles (AuNPs) in Gum Arabic (GA) solution via laser ablation as a CT contrast agent. The optical properties were achieved using the absorption spectroscopic technique whereas the morphology and size distribution were investigated by TEM and ImageJ software. TEM image shows greater stability and spherical shape of GA-AuNPs with smaller size at 1.85 ± 0.99 nm compared to AuNPs without GA. The absorption spectrum of pure AuNPs has a lower absorption peak height in the visible range at λ = 521 nm, while the spectrum of GA-AuNPs has a higher plasmon peak height at λ = 514 nm with a blue shift towards lower wavelengths. The concentration of GA that dissolved in 10 mL of DI water via laser ablation is set at 20 mg. Increasing the number of pulses has only a minor effect on particle size distribution, which remains tiny in the nanometer range (less than 3 nm). For energies greater than 200 mJ, there is a blue shift toward shorter wavelengths. As the concentration of GA-AuNPs increases, the CT number is also increased indicating good image contrast. It can be concluded that there is a positive and significant influence of GA as a reducing agent for AuNPs, and a contrast agent for CT imaging which highlights its superiority in future medical applications.

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