Evaluation of immune response to Hepatitis B vaccine in health care workers at a tertiary care hospital in Pakistan: an observational prospective study

Zeeshan, Mohammad; Jabeen, Kauser; Ali, Anita; Ali, Ailia W; Farooqui, Saadia; Mehraj, Vikram; Zafar, Afia

doi:10.1186/1471-2334-7-120

Cited by 85 publications

(85 citation statements)

References 20 publications

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“…In multivariate analyses, being male is a significant predictor of being ‘non-responsive’ to the HBV vaccine; thus, adult females show higher rates of seroconversion following exposure to the HBV vaccine than do males [81]. Greater efficacy of the HBV vaccine in females also may contribute to reduced prevalence of HBV and development of liver cancer among females compared with males.…”

Section: The Responses To and Outcome Of Viral Infection Antiviral Tmentioning

confidence: 99%

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

2012

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Summary The intensity and prevalence of viral infections are typically higher in males, whereas disease outcome can be worse for females. Females mount higher innate and adaptive immune responses than males, which can result in faster clearance of viruses, but also contributes to increased development of immunopathology. In response to viral vaccines, females mount higher antibody responses and experience more adverse reactions than males. The efficacy of antiviral drugs at reducing viral load differs between the sexes, and the adverse reactions to antiviral drugs are typically greater in females than males. Several variables should be considered when evaluating male/female differences in responses to viral infection and treatment: these include hormones, genes, and gender-specific factors related to access to, and compliance with, treatment. Knowledge that the sexes differ in their responses to viruses and to treatments for viral diseases should influence the recommended course of action differently for males and females.

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Section: The Responses To and Outcome Of Viral Infection Antiviral Tmentioning

confidence: 99%

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

2012

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“…This exposure can put them at risk of many blood-borne diseases including hepatitis B [1,2]. Globally, 2 billion people are infected with hepatitis B virus (HBV) [3][4][5]. With 563 000 deaths has 4 administrative parts (sub-districts called talukas), i.e., Sukkur City, Rohri, Saleh Pat and Pano Aqil.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatitis B virus infection among barbers and their knowledge, attitude and practices in the district of Sukkur, Sindh

Abbasi¹,

Fatmi²,

Kadir³

et al. 2014

IJOMEH

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Objectives: Several occupations in developing countries lag behind in ensuring the safety of their workers in occupational settings. Lack of implementation of safety guidelines at workplaces can expose workers to health risks. In Pakistan, barbers are one of the un-regulated occupational groups. Low literacy, increased frequency of direct skin contact and blade/razors use can expose barbers to body fluids including blood of the customers. We conducted this study in order to determine hepatitis B virus (HBV) prevalence among barbers and their knowledge, attitude and practices in a peri-urban district of Sindh. Material and Methods: Three hundred eighty-five barbers from the Sukkur district were interviewed using a structured questionnaire. Blood samples were collected and tested for HBsAg. A scale was built to determine the proportions of responses to knowledge, attitude and practice items. Results: The prevalence of HBV among barbers was 2.1%. The barbers' knowledge on HBV and its transmission routes was poor. The response to attitude items was good, except that only 35.1% of the participants agreed to have vaccination against HBV. The overall performance on the knowledge and practice scales was poor compared to the attitude scale on which 80% of the barbers performed well. Conclusion: The prevalence of HBV among barbers was lower compared to the available national figures for the prevalence among the general population.

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“…Out of 102 participants, 39 had received prior (childhood) vaccination, 20 in group I and 24 in group II (Table 4). Thomas et al, (2015); Averhoff et al, (1998);Platkov et al, (2001); Zeeshan et al, (2007);Chathurang et al, (2013) and Sarwat et al, (2014) showed different rates of seroconversion rates, 98.89%, 88%, 86.5%, 86%, 90.1% and 35% respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, it is crucial to check postvaccination HBsAb in all the HCWs. This strategy will ensure safety at work by reducing nosocomial transmission and will have a cost effective impact at an individual as well as a national level, which is very much desired in a resource-limited country (Zeeshan et al, 2007).…”

Section: Article Infomentioning

confidence: 99%

Study of Hepatitis B Surface Antibody Titres in Female Medical Students Post Vaccination

Nagamani¹,

Naidu²,

Jayanthi³

2017

Int.J.Curr.Microbiol.App.Sci

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Evaluation of immune response to Hepatitis B vaccine in health care workers at a tertiary care hospital in Pakistan: an observational prospective study

Cited by 85 publications

References 20 publications

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

Prevalence of hepatitis B virus infection among barbers and their knowledge, attitude and practices in the district of Sukkur, Sindh

Study of Hepatitis B Surface Antibody Titres in Female Medical Students Post Vaccination

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