Evaluation of immunomodulatory activities of essential oils by high content analysis

Lang, Marie; Ferron, Pierre-Jean; Bursztyka, Julian; Montjarret, Aude; Duteil, Emmanuel; Bazire, Alexis; Bedoux, Gilles

doi:10.1016/j.jbiotec.2019.07.010

Cited by 17 publications

(10 citation statements)

References 24 publications

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“…O. vulgare has been traditionally used in Switzerland in hens with gastrointestinal disorders 17 . Five experiments used the oregano essential oil, which is rich in phenolic compounds, containing carvacrol as its main compound 90 , 92 . Carvacrol has been reported to have antibacterial effects in vitro (i.e., due to the phenols containing an isopropyl group at the para-position 93 , 94 and via altering the structure of phospholipid membranes of bacteria) 95 .…”

Section: Discussionmentioning

confidence: 99%

Medicinal Plants for Prophylaxis and Therapy of Common Infectious Diseases In Poultry–A Systematic Review of In Vivo Studies

et al. 2021

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Medicinal plants for prophylaxis and therapy of common infectious diseases in poultry have been studied for several years. The goal of this review was to systematically identify plant species and evaluate their potential in prophylaxis and therapy of common diseases in poultry caused by bacteria and gastrointestinal protozoa. The procedure followed the recommendations of the PRISMA statement and the AMSTAR measurement tool. The PICOS scheme was used to design the research questions. Two databases were consulted, and publications were manually selected, according to predefined in- and exclusion criteria. A scoring system was established to evaluate the remaining publications. Initially, 4197 identified publications were found, and 77 publications remained after manual sorting, including 38 publications with 70 experiments on bacterial infections and 39 publications with 78 experiments on gastrointestinal protozoa. In total, 83 plant species from 42 families were identified. Asteraceae and Lamiaceae were the most frequently found families with Artemisia annua being the most frequently found plant, followed by Origanum vulgare. As compared to placebo and positive or negative control groups, antimicrobial effects were found in 46 experiments, prebiotic effects in 19 experiments, and antiprotozoal effects in 47 experiments. In summary, a total of 274 positive effects predominated over 241 zero effects and 37 negative effects. Data indicate that O. vulgare, Coriandrum sativum, A. annua, and Bidens pilosa are promising plant species for prophylaxis and therapy of bacterial and protozoal diseases in poultry.

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Section: Discussionmentioning

confidence: 99%

Medicinal Plants for Prophylaxis and Therapy of Common Infectious Diseases In Poultry–A Systematic Review of In Vivo Studies

et al. 2021

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“…Previous publications showed that S. typhimurium is able to regulate the immune system of C. elegans to promote its infection [ 26 ], and that its installation in the digestive system is combined with oxidative stress [ 25 ]. As both immunomodulative [ 48 ] and antioxidant activities of EOs are recognized, further work should also focus on the development of a multiparametric assay that integrates the measurement of oxidative bursts related to infection in C. elegans .…”

Section: Discussionmentioning

confidence: 99%

Cinnamomum cassia and Syzygium aromaticum Essential Oils Reduce the Colonization of Salmonella Typhimurium in an In Vivo Infection Model Using Caenorhabditis elegans

Lang

Montjarret²,

Duteil³

et al. 2021

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The regulation of intestinal colonization in livestock by means of non-bactericidal additives is an important management lever for zoonotic bacteria such as Salmonella spp. Caenorhabditis elegans is proposed here as a model for the evaluation of five essential oils (EOs) as anti-colonization products against Salmonella Typhimurium. An evaluation of the toxicity of EOs for C. elegans showed LD50 values ranging from 74.5 ± 9.6 µg/mL for Cinnamomum cassia (CEO) to 271.6 ± 14.9 µg/mL for Syzygium aromaticum (SyEO). Both EOs significantly inhibited bacterial colonization in the digestive tract of C. elegans with reductions of 0.88 and 0.70 log CFU/nematode at nontoxic concentrations of 50 µg/mL and 150 µg/mL, respectively. With the minimal bactericidal concentrations of CEO and SyEO against S. Typhimurium being 312.5 µg/mL and 625 µg/mL, respectively, an antibacterial effect can be excluded to explain the inhibition of the bacterial load. The anti-colonizing activity of these two EOs could, however, be related to an inhibition of the swimming motility, which was significantly reduced by 23.47% for CEO at 50 µg/mL and 19.56% for SyEO at 150 µg/mL. This study shows the potential of C. elegans as a predictive in vivo model of anti-colonizing activities that is suitable for the evaluation of essential oils.

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“…It also has antibiofilm and anticancer activities [ 9 , 55 ]. Cinnamon EO contains 80% cinnamaldehyde, which is responsible for cinnamon’s natural fragrance [ 4 , 56 ]. Studies have also found that cinnamaldehyde has an antimicrobial, antioxidative, anti-inflammatory and immunomodulatory effect [ 57 ].…”

Section: Immuno-modulatory Activities Of Aldehydesmentioning

confidence: 99%

Contribution of Aldehydes and Their Derivatives to Antimicrobial and Immunomodulatory Activities

et al. 2022

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Essential oils (EOs) are intricate combinations of evaporative compounds produced by aromatic plants and extracted by distillation or expression. EOs are natural secondary metabolites derived from plants and have been found to be useful in food and nutraceutical manufacturing, perfumery and cosmetics; they have also been found to alleviate the phenomenon of antimicrobial resistance (AMR) in addition to functioning as antibacterial and antifungal agents, balancing menstrual cycles and being efficacious as an immune system booster. Several main aldehyde constituents can be found in different types of EOs, and thus, aldehydes and their derivatives will be the main focus of this study with regard to their antimicrobial, antioxidative, anti-inflammatory and immunomodulatory effects. This brief study also explores the activity of aldehydes and their derivatives against pathogenic bacteria for future use in the clinical setting.

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Evaluation of immunomodulatory activities of essential oils by high content analysis

Cited by 17 publications

References 24 publications

Medicinal Plants for Prophylaxis and Therapy of Common Infectious Diseases In Poultry–A Systematic Review of In Vivo Studies

Medicinal Plants for Prophylaxis and Therapy of Common Infectious Diseases In Poultry–A Systematic Review of In Vivo Studies

Cinnamomum cassia and Syzygium aromaticum Essential Oils Reduce the Colonization of Salmonella Typhimurium in an In Vivo Infection Model Using Caenorhabditis elegans

Contribution of Aldehydes and Their Derivatives to Antimicrobial and Immunomodulatory Activities

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