Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications

Jiang, Congshan; Jiang, Kaichong; Li, Xiaowei; Zhang, Ning; Zhu, Wenhua; Meng, Liesu; Zhang, Yanmin; Lu, Shemin

doi:10.1016/j.jpha.2022.10.003

Journal of Pharmaceutical Analysis

2023

DOI: 10.1016/j.jpha.2022.10.003

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Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications

Congshan Jiang

Kaichong Jiang

Xiaowei Li

et al.

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Cited by 4 publications

References 110 publications

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Principles of lipid nanoparticle design for mRNA delivery

Zhang,

Gao

et al. 2024

BMEMat

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AbstractmRNA therapeutics have significantly evolved within the life sciences, particularly in applications such as vaccines, tumor immunotherapy, protein replacement, gene editing, and monoclonal antibody therapy. To fully realize the potential of mRNA drugs and mitigate the adverse effects, substantial vector materials have been developed for delivery of these pharmaceutical agents. Lipid nanoparticles (LNPs) represent the most clinically advanced mRNA carriers, recognized by U.S. Food and Drug Administration approved mRNA vaccines and numerous clinical trials. Diverse therapeutic applications necessitate tailored design of LNPs. Herein, we outline the principles of LNP design for mRNA delivery, focusing specifically on their effectiveness, targeting capabilities, safety profiles, and nanoparticle stability. Additionally, we present the latest advancements in mRNA‐LNP technology. This review aims to elucidate the benefits and design principles of LNP delivery systems for mRNA therapeutics, providing insights into breakthroughs and innovative ideas for further enhancing these advantages. These summaries are dedicated to promoting the broader applications of LNP‐mRNA drugs, aiming to advance the treatment of serious diseases in an effective and safe manner.

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Principles of lipid nanoparticle design for mRNA delivery

Zhang,

Gao

et al. 2024

BMEMat

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An overview of lipid constituents in lipid nanoparticle mRNA delivery systems

Wu,

Lin,

Shi

et al. 2024

WIREs Nanomed Nanobiotechnol

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AbstractmRNA therapeutics have shown great potential for a broad spectrum of disease treatment. However, the challenges of mRNA's inherent instability and difficulty in cellular entry have hindered its progress in the biomedical field. To address the cellular barriers and deliver mRNA to cells of interest, various delivery systems are designed. Among these, lipid nanoparticles (LNPs) stand out as the most extensively used mRNA delivery systems, particularly following the clinical approvals of corona virus disease 2019 (COVID‐19) mRNA vaccines. LNPs are comprised of ionizable cationic lipids, phospholipids, cholesterol, and polyethylene glycol derived lipids (PEG‐lipids). In this review, we primarily summarize the recent advancements of the LNP mRNA delivery technology, focusing on the structures of four lipid constituents and their biomedical applications. We delve into structure–activity relationships of the lipids, while also exploring the future prospects and challenges in developing more efficacious mRNA delivery systems.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials > Lipid‐Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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The implication of infection with respiratory syncytial virus in pediatric recurrent wheezing and asthma: knowledge expanded post-COVID-19 era

Su,

Jiang,

Zhang

2023

Eur J Clin Microbiol Infect Dis

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Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications

Cited by 4 publications

References 110 publications

Principles of lipid nanoparticle design for mRNA delivery

Principles of lipid nanoparticle design for mRNA delivery

An overview of lipid constituents in lipid nanoparticle mRNA delivery systems

The implication of infection with respiratory syncytial virus in pediatric recurrent wheezing and asthma: knowledge expanded post-COVID-19 era

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