2018
DOI: 10.2147/ijn.s170745
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Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

Abstract: Nanotechnology is an interdisciplinary science that has developed rapidly in recent years. Metallic nanoparticles (NPs) are increasingly utilized in dermatology and cosmetology, because of their unique properties. However, skin exposure to NPs raises concerns regarding their transdermal toxicity. The tight junctions of epithelial cells form the skin barrier, which protects the host against external substances. Recent studies have found that NPs can pass through the skin barrier into deeper layers, indicating t… Show more

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Cited by 94 publications
(47 citation statements)
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“…However, so far, there have been very few confirmed cases of contact dermatitis secondary to silver-containing wound products like silver sulfadiazine and skin markers that contain silver nitrate [187,188]. Contrary, there is considerable evidence for the significant transdermal penetration of AgNPs into capillaries during the use of surgical dressings, textiles, and cosmetics [189,190]. In order to elucidate the mechanism of cytotoxicity, Samberg et al [129] evaluated the potential ability of AgNPs to penetrate porcine skin and showed the existence of the focal inflammation and localization of AgNPs on the surface and in the upper stratum corneum layers of porcine skin.…”
Section: N/a [166]mentioning
confidence: 99%
“…However, so far, there have been very few confirmed cases of contact dermatitis secondary to silver-containing wound products like silver sulfadiazine and skin markers that contain silver nitrate [187,188]. Contrary, there is considerable evidence for the significant transdermal penetration of AgNPs into capillaries during the use of surgical dressings, textiles, and cosmetics [189,190]. In order to elucidate the mechanism of cytotoxicity, Samberg et al [129] evaluated the potential ability of AgNPs to penetrate porcine skin and showed the existence of the focal inflammation and localization of AgNPs on the surface and in the upper stratum corneum layers of porcine skin.…”
Section: N/a [166]mentioning
confidence: 99%
“…For people with a skin barrier dysfunction (such as psoriasis, atopic dermatitis, acne), whose skin continuity may be interrupted for various reasons, the penetration of nanoparticles into the deeper layers of the skin is even easier [48][49][50]. Nanoparticles move between corneocytes arranged in a "brick-like" manner in the lipid layer [51]. The efficiency of penetration of nanoparticles through the skin depends on their size [52].…”
Section: Drug Carriersmentioning
confidence: 99%
“…Tak et al presented assumptions regarding the impact of the shape of silver nanoparticles on skin penetration, diffusion coefficient as well as speed and depth of penetration. Silver nanoparticles of longitudinal shape penetrated deeper into the stratum corneum [51].…”
Section: Drug Carriersmentioning
confidence: 99%
“…As one typical example, metal oxide nanoparticles which accumulated in skin furrows and hair follicles [32] were shown to trigger inflammation via induction of reactive oxygen species, [17,33] reported. [34] But the keratinocyte activation also contributes directly to the uptake of exogenous material by LCs, which is typically accomplished by dynamic interactions of LC dendrites with the tight junctions that connect keratinocytes. Those tri-cellular contacts enable LCs to reach out to superficial compartments and gain access to external antigens [35] (Figure 1).…”
Section: The Hair Follicle Plays a Key Role In The Mediation Of Locmentioning
confidence: 99%