Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the β-(1→2)-Linked Cell Wall Mannans of Candida albicans

Ranta, Kaarina; Nieminen, Kaisa; Ekholm, Filip S.; Poláková, Monika; Roslund, Mattias U.; Saloranta, Tiina; Leino, Reko; Savolainen, J.

doi:10.1128/cvi.00298-12

Cited by 21 publications

(13 citation statements)

References 37 publications

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“…Besides the above‐mentioned d ‐mannose physiological function used in the treatment of corresponding diseases, d ‐mannose is used as an inexpensive starting material for the synthesis of immunostimulatory agents (Ranta and others ), antitumor agents (Kamel and others ), vitamins (Chen and others ), and d ‐mannitol (Mishra and Hwang ). The global market for mannitol is estimated to have annual sales of approximately $100 million.…”

Section: Applications Of D‐mannosementioning

confidence: 99%

“…d ‐Mannose has been a focus of interest among numerous industrial sectors because of its valuable properties, and presently there is great demand for a wide range of applications (Galis and others ; Ranta and others ; Sutton and Wilcox ). Hence, the cost‐effective production of commercially available d ‐mannose on a large scale is currently required in the world market.…”

Section: Introductionmentioning

confidence: 99%

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d‐Mannose: Properties, Production, and Applications: An Overview

Shi

Zhang

et al. 2016

Comp Rev Food Sci Food Safe

154

115

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d-Mannose is a C-2 epimer of d-glucose, which is a natural monosaccharide. It can be obtained from both plants and microorganisms. Chemical synthesis and biotransformation of d-mannose from d-fructose or d-glucose by using d-mannose isomerases, d-lyxose isomerases, and cellobiose 2-epimerase were intensively studied. d-Mannose is an important component of polysaccharides and glycoproteins. It has been widely used in the food, pharmaceutical, and poultry industries, acting as the source of dietary supplements, starting material for the synthesis of drugs and blocking colonization in animal feeds. d-Mannose is a glyconutrient with high research value in basic science because of its structure and function. This article presents a review of current studies on sources, characteristics, production, and application of d-mannose.

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Section: Applications Of D‐mannosementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

d‐Mannose: Properties, Production, and Applications: An Overview

Shi

Zhang

et al. 2016

Comp Rev Food Sci Food Safe

154

115

View full text Add to dashboard Cite

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“…[36,37] Althoughi nt he present case the possible influence of the triazole moiety on the biological activity of the glycoclusters 1-3 cannotb er uled out completely,i tm ust be emphasized that out of av ery large number of oligovalent b-(1!2) mannosides screened during our previous investigations, [17][18][19] of which several othersa lso contained triazole units, the only compound showingp romising in vitro activity was compound 1 and now www.chemmedchem.org here its analogues 2 and 3.C ommon features shared by these three active compounds are:1 )fully acetylatedt rivalent b-(1! This makes them accessible for biological targets,a nd it is known that triazoles can take part in biological events.…”

Section: Compoundmentioning

confidence: 99%

Acetylated Trivalent Mannobioses: Chemical Modification, Structural Elucidation, and Biological Evaluation

et al. 2016

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People suffering from allergies can be treated with repeated injections of increasing amounts of a specific allergen. This type of specific immunotherapy is currently the only way to treat the underlying pathological immune response associated with an allergy. The approach can afford long-lasting protection, but the process takes 3-5 years, can produce allergic reactions, and in severe cases treatment is often aborted due to anaphylaxis. However, treatment can be optimized with the use of specific adjuvants that modify the immune response, its duration, and that increase the production of the correct type of antibodies. In the pursuit of such adjuvants, two new trivalent acetylated β-(1→2)-linked mannobioses based on a previously discovered lead molecule were prepared. The new molecules, along with the previously developed lead, were investigated by rigorous NMR and molecular modeling experiments in order to elucidate their behavior and preferred conformations in solution. Furthermore, the molecules were subjected to a biological investigation in which their immunostimulatory properties were evaluated by assessing their effect on the production of TH 2-type cytokine interleukin-4 (IL-4) and Treg pro-inflammatory cytokine tumor necrosis factor (TNF). Treatment of peripheral mononuclear blood cell cultures from patients suffering from birch allergy with birch allergen Bet v induced a strong IL-4 response, whereas the same treatment together with the trivalent acetylated mannobioses caused significant suppression of the induced IL-4.

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“…In addition, it is an important glyconutrient for human health, and is recommended as a dietary supplement for infants and children . In addition, it is also a key ingredient or intermediate for the synthesis of antitumor agents, immunostimulatory agents, auxiliary moisturizing agents, d ‐mannitol, and vitamins . Furthermore, d ‐mannose is an effective additive in animal feeds, which can inhibit the growth of intestinal pathogens .…”

Section: Introductionmentioning

confidence: 99%