Evaluation of Immunotoxicity of Shizukaol B Isolated from Chloranthus japonicus

Abstract

Abstractduced apoptosis in B cells, but not T cells, macrophages, and dendritic cells.

Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers

“…Plants containing LSs have been used as famous natural medicines to treat blood stasis, inflammation, drainage, and detoxification. 38,39 Thus, the diverse LSs also show various and significant biological activities, such as anti-inflammation, 40–43 antitumor, 44–46 and anti-infection. 47–50 In particular, 13′- O -methyl succinylshizukaol C has been reported to show about 1000-fold stronger antimalarial activity than that of artemisinin.…”

Asymmetric total syntheses of sarbracholide and shizukaol B

“…6 Taking the most abundant [4 + 2] head-to-back-type oligomers as an example (Scheme 2), sarbracholide 8 targets chloroquine-resistant Plasmodium falciparum with picomolar activity (EC 50 = 4.3 ± 0.3 pM) and is the most potent antimalarial agent reported so far, with an activity about 1000 times that of artemisinin, 6 f while shizukaol B 9 shows excellent anti-HIV-1 (EC 50 = 1.4 nM) and antimalarial (EC 50 = 27 ± 3 nM) activities. 6 a , i ,7 Given their intriguing structures as well as excellent biological activities, significant efforts toward the synthetic construction of lindenane monomers 8 and oligomers 9 have been reported recently.…”