Evaluation of in vitro anti-acne activities of Ocimum basilicum L. water extract

He, Hongping; Wang, De‐Xian; Song, Liya; He, Congfen

doi:10.1016/j.indcrop.2022.115205

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…14,15 Ocimum basilicum extract inhibits C. acnes proliferation and suppresses Cutibacterium acnes-induced inflammation in vivo. 16 Hamamelis virginiana bark has potential anti-acne activity through its antioxidant, anti-cutibacterium acnes and anti-inflammatory activities on human keratinocytes. 17 Extracts of Chamaecyparis obtusa significantly reduced the number of inflammatory lesions in acne patients.…”

Section: Phytotherapy Of Acnementioning

confidence: 99%

Untitled

2023

JDC

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The search terms used included acne, wound healing, psoriasis combined with the terms "herbal medicine", "medicinal plants,"phytotherapy", "plants extracts" based on recent literature available in six electronic databases including Scopus, Web of Sciences, PubMed, Google Scholar, Science Direct and Hinari. Articles, reviews of in vitro or in vivo studies and clinical evaluations of plant extracts or plant formulations were considered. AcneAcne is a dermatological condition of the pilosebaceous follicle that affects 9.4% of the world's population. 3 It is a condition that represents one of the most frequent reasons for consultation in dermatology. 4 The condition usually attacks adolescents with a prevalence of over 80% worldwide. 3,4 Acne is characterised by the appearance of pimples, nodules, pus blisters, cysts, and scars on the body, usually on the face and chest. The affection can cause an acute

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Section: Phytotherapy Of Acnementioning

confidence: 99%

Untitled

2023

JDC

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Section: Phytotherapy Of Acnementioning

confidence: 99%

Pharmacological mechanisms of medicinal plant extracts in the treatment of dermatological diseases: in vitro, in vivo studies and clinical trials

KOMBATE¹,

Metowogo²

2023

JDC

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Dermatological diseases are common inflammatory affections of the skin. In recent times, interest in herbal medicine for the treatment of dermatological diseases has become more than necessary due to the side effects of conventional drugs and their ineffectiveness. To this end, the use of herbal medicine is a promising approach. The objective of this review is to list scientific articles and reviews on plant extracts or plant formulations used in the treatment of dermatological diseases including acne, psoriasis, dermatitis and wounds which are the most common affections. The following scientific databases were consulted: PubMed, Inari, science direct, Google scholar, Web of Science and Scopus. This review provides evidence that herbal medicines will be emerging and promising treatments for dermatological conditions. However, better quality evidence and standardized methodologies are needed to support and further investigate the efficacy, safety and security of these plants.

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In-vitro anti-acne activity of Teucrium oliverianum methanolic extract against Cutibacterium acnes

Al-Ghanayem

2024

Front. Pharmacol.

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BackgroundAcne vulgaris is a skin infection widely seen in adolescents between 10–19 years with males affected more than females. It mainly affects the face but may also affect the back and chest. The symptoms vary with mild acne manifesting as comedones and moderate acne as inflammatory lesions (papulopustular), nodules, and mild scarring while severe acne has the same symptoms that have not subsided within 6 months of treatment. Various treatments including topical medications containing different antibiotics are used to treat acne. Recently, herbal treatments have been shown as better alternatives to conventional treatment. Teucrium oliverianum Ging. ex Benth (Lamiaceae) is traditionally used for skin infections such as wound healing and biofilm formation.MethodologyMethanolic extract of T. oliverianum was subjected to liquid chromatography-mass spectrometry (LC-MS) analysis, and its antibacterial effect against Cutibacterium acnes. The anti-acne, anti-inflammatory, and antioxidant effects were also assessed using HaCaT cells infected with C. acnes. The cytotoxicity of the extract was evaluated using a neutral red uptake assay, and anti-inflammatory effects were determined by measuring TNF-α, IL-1β, INF-γ, and COX2 inhibition. The antioxidant action was assessed by ROS generation in HaCaT cells infected with C. acnes.ResultsLC-MS analysis of the extract showed the presence of 16 different metabolites with L-carnitine, esculin sesquihydrate, and gamma-linoleic acid as major metabolites. The methanolic extract of T. oliverianum showed an antibacterial effect against C. acnes with an IC50 value of 263.2 μg/mL. The extract attenuated the cytotoxicity of C. acnes on the HaCaT cell and the IC50 was found to be 676.2 μg/mL. It also decreased dose-dependently the expression of TNF-α, IL-1β, INF-γ, and inhibited COX2 in the HaCaT cells infected with C. acnes. It also decreased the generation of reactive oxygen species.ConclusionThe results support the use of T. oliverianum as an anti-acne agent but it possesses mild antibacterial action. It showed anti-inflammatory effects in HaCaT cells infected with C. acnes. It is also an effective antioxidant and decreased the generation of reactive oxygen species. Comparison of the anti-acne effects and adverse reactions of extract with other treatments will provide more insight into its clinical efficacy and toxicity.

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Evaluation of in vitro anti-acne activities of Ocimum basilicum L. water extract

Cited by 3 publications

References 51 publications

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Pharmacological mechanisms of medicinal plant extracts in the treatment of dermatological diseases: in vitro, in vivo studies and clinical trials

In-vitro anti-acne activity of Teucrium oliverianum methanolic extract against Cutibacterium acnes

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