Evaluation of in vitro bioactivity and in vitro biocompatibility of Polycaprolactone/Hyaluronic acid/Multiwalled Carbon Nanotubes/Extract from Mimosa tenuiflora composites

Limón-Martínez, R.J.; Olivas–Armendáriz, I.; Sosa-Rodarte, E.; Rodríguez-Rodríguez, Carlos; Hernández-Paz, J.F.; Acosta-Torres, Laura Susana; García-Contreras, René; Santos-Rodríguez, Elí; Martel-Estrada, Santos-Adriana

doi:10.3233/bme-181036

Cited by 1 publication

(1 citation statement)

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“…The long-term effort is made to use MWCNTs notable electrical, thermal, mechanical and chemical characteristics, to improve the properties of polymer biocomposites. The introduction of MWCNT as refurbishing materials into the polymer medium leads to substantial changes in the mechanical characteristics resulting in better properties for biocomposite than pristine polymer ( Limón-Martínez et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite based biocomposite scaffold: A highly biocompatible material for bone regeneration

Li¹,

Qin

Lakshmanan

et al. 2020

Saudi Journal of Biological Sciences

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The conventional approaches for treating bone defects such as autografts donor tissue shortages and allografts transmission of diseases pose many shortcomings. The objective of this study was to design a nano strontium/magnesium doped hydroxyapatite (Sr/Mg-HA) with chitosan (CTS) and multi-walled carbon nanotubes (MWCNT) (Sr/Mg-HA/MWCNT/CTS) biocomposite was created to support the growth of osteoblasts using a solvent evaporation method. To help the growth of osteoblasts, a solvent evaporation technique was used to design a nano strontium/magnesium doped hydroxyapatite with chitosan and multi-walled carbon nanotubes biocomposite. We studied the biocompatibility and efficiency in vitro of biocomposite following physicochemical analyzes. Tests of biocompatibility, cell proliferation, mineralization, and osteogenic differentiation have shown that in-vitro safety and effectiveness of biocomposite are good. The performance of biocomposite was more efficient in in-vitro as well as in vivo experiments than in Sr/Mg-HA nanoparticles. Briefly, the Sr/Mg-HA/MWCNT/CTS biocomposite is an ideal candidate for effective bone repair in clinics with excellent mechanical properties with durable multi-biofunctional antibacterial properties and osteoinductivity.

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Section: Introductionmentioning

confidence: 99%