Evaluation of In Vitro Immunomodulatory Activity of Withania somnifera Roots on Human Neutrophils

Arora, Asha; Solanki, Pallavi; Kumar, Dinesh

doi:10.1007/s12010-021-03518-8

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…Immune responsiveness against pathogens may be enhanced by immunomodulatory agents of vegetal and animal origin through the improvement of the non-specific immune response (Arora et al, 2021), and WS may be utilized as an immunomodulatory agent as it increases phagocytic activity and IgG levels in mice (Kanyaiya et al, 2014). Reduction in interleukin-6 level and increase in red blood cell count, total leukocyte count, and hemoglobin levels were recorded in equines treated with root extract of W. somnifera (Priyanka et al, 2020).…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Reduction in interleukin-6 level and increase in red blood cell count, total leukocyte count, and hemoglobin levels were recorded in equines treated with root extract of W. somnifera (Priyanka et al, 2020). In an in vitro study, Arora et al (2021) assessed the immunomodulatory impacts of the tannins from the WS root. They demonstrated that tannins stimulated the phagocytic activity of neutrophils and increased neutrophil motility because tannins act as a chemoattractant.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Withania somnifera as a Phytoherbal Growth Promoter for Broiler Farming – A Review

Oliveira

Attia

Khafaga

et al. 2024

Annals of Animal Science

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Poultry production significantly contributes to bridging the food gap worldwide. Several nations have limited the usage of antibiotic growth promotors due to bacterial resistance to antibiotics and the occurrence of residual antibiotics in the edible tissues of birds. The world is now turning to using natural alternatives to increase poultry production as well as birds’ resistance to diseases. Withania somnifera (WS; family: Solanaceae) is a precious medicinal herb utilized in several countries due to its distinct chemical, medicinal, and physiological properties. This plant has antioxidant, anti-aging, antimicrobial, antitumor, hepatoprotective, cardioprotective, neuroprotective, immunomodulatory, antidiabetic, antistress, and growth-promoting activities. In poultry, the dietary inclusion of WS revealed a promising result in enhancing productive performance, increasing disease resistance, reducing stress effects, and maintaining the bird’s health. Thus, the current review highlights the morphological features, distribution, chemical structure, and pharmacological features of Withania somnifera as a growth promoter herb for farming broiler chickens.

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Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

Withania somnifera as a Phytoherbal Growth Promoter for Broiler Farming – A Review

Oliveira

Attia

Khafaga

et al. 2024

Annals of Animal Science

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“…Studies report that various phytoconstituents forming the dietary constituents are capable of protecting against SARS-CoV-2 infection [11] . Withania somnifera, Aswagandha, the popular medicinal plant is reported to exhibit immunomodulatory activity in vitro [12] . The study reveals that the phytocompounds isolated from the roots of Withania somnifera has significant immunomodulatory impact on human neutrophils [12] .…”

Section: Introductionmentioning

confidence: 99%

“…Withania somnifera, Aswagandha, the popular medicinal plant is reported to exhibit immunomodulatory activity in vitro [12] . The study reveals that the phytocompounds isolated from the roots of Withania somnifera has significant immunomodulatory impact on human neutrophils [12] . The phytocompounds from the Withania somnifera (WS) have also been reported to have immunomodulatory effects in vivo on mouse [13] .…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Phytocompounds from Withania somnifera (L.) Dunal (Ashwagandha) Against COVID-19

Singha,

Ghosh,

Ghosh

2024

Trends Immunother.

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Withania somnifera is a famous medicinal plant. It is popularly known as Aswagandha. This plant has been in use in Ayurveda and Unani medicine for ages. The medicinal plant has immense medicinal properties. The plant is rich in potent medicinal phytocompounds. These phytocompounds are known to have potent antioxidant, antiviral, antibacterial and immunomodulatory efficacies. Our immune system is the key player in n fighting back any kind of pathogeni attack on us. Withania somnifera extract and certain isolated phytocompounds from the plant are known to boost our immune system. Studies show that the mechanisms of immunomodulatory actions of the bioactive phytocompounds from Withania somnifera are by affecting the various cellular signaling pathways. These primarily involve the signaling pathways associated with the receptors present on the vital immune cells like the dendritic cells, T-cells and B-cells. Thus, some of the compounds of Withania suppress or activate certain components of the innate and adaptive immune system. Unlike synthetic adjuvants, the natural plant derived phytocompounds and their derivatives, as those from the Withania sp. are free from such risk factors. A strong immune system is the best possession to fight back invasions by microbes like bacteria and viruses like the SARS-CoV-2. Detailed and compact knowledge of the compounds from Withania sp. and their mechanism of modulating and impacting our immune system may make the ways for development of new supportive therapies against almost all different types of diseases including COVID 19.

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CRISPR-Cas-Mediated Optimization of Plant-Derived Natural Products of Biomedical Significance

Asha,

Sunita

2024

Reference Series in Phytochemistry

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Evaluation of In Vitro Immunomodulatory Activity of Withania somnifera Roots on Human Neutrophils

Cited by 4 publications

References 2 publications

Withania somnifera as a Phytoherbal Growth Promoter for Broiler Farming – A Review

Withania somnifera as a Phytoherbal Growth Promoter for Broiler Farming – A Review

Immunomodulatory Phytocompounds from Withania somnifera (L.) Dunal (Ashwagandha) Against COVID-19

CRISPR-Cas-Mediated Optimization of Plant-Derived Natural Products of Biomedical Significance

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