Evaluation of in vitro susceptibility of fosfomycin among Enterobacteriaceae isolates from urine cultures: A study from Puducherry

Srirangaraj, Sreenivasan; Kali, Arunava; Charles, Marie Victor Pravin; Kunigal, Seetha

doi:10.4103/jlp.jlp_27_19

Cited by 11 publications

(7 citation statements)

References 17 publications

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“…With gentamicin, the resistance did not exceed 5.4% with E. coli and 10.1% with K. pneumoniae. However, this molecule showed a high resistance rate of 52.3% and 68% against uropathogenic enterobacterial isolates in an Indian and Ethiopian study, respectively [48,49].…”

Section: Discussionmentioning

confidence: 93%

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Antibiotic resistance in uropathogenic enterobacteria

et al. 2021

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Multidrug-resistant Enterobacteriaceae are a major public health threat worldwide. These germs are the most redoubtable because they are producers of beta-lactamases and possess other mechanisms of resistance to many antibiotics. The objective of this work is to identify isolated strains of Enterobacteriaceae and to study their antibiotic resistance profiles, thus contributing to the surveillance of antibioresistance. This is a retrospective study over a period of three years (2018-2020) including urine samples taken in the region of Rabat-Salé-Zaire and examined at the laboratory of Epidemic Diseases in National Institute of Hygiene of Rabat. Enterobacteriaceae were the most frequent germs with a predominance of Escherichia coli (68%) followed by Klebsiella pneumoniae (23%). Extended-spectrum beta-lactamase-producing Enterobacteriaceae accounted for 10.5%. The highest resistance was observed with amoxicillin, followed by ticarcillin, cefalotin, trimethoprim/sulfamethoxazole, amoxicillin+clavulanic acid, nalidixic acid and finally ciprofloxacin and norfloxacin. The aminoglycosides and the 2nd and 3rd cephalosporins were the most active molecules. The sensitivity of imipenem and ertapenem was 100%. This study shows the worrying appearance of resistance to the usual antibiotics in uropathogenic enterobacteria. Rational prescription of antibiotics and monitoring of the evolution of bacterial resistance are necessary in each region.

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Section: Discussionmentioning

confidence: 93%

“…We mention the use of other molecules such as the pipiracillin-tazobactam combination [53]. Another study suggested that fosfomycin and nitrofurantoin could be an excellent therapeutic option for UTIs [20,49,54]. In Morocco, fosfomycin has shown promising in vitro activity against multidrug-resistant urinary tract infections [24].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance in uropathogenic enterobacteria

et al. 2021

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“…Another study done by Wali et al in their study 24 Enterococcus species were isolated. 20 isolates (80%) of enterococcal species showed to be sensitive to nitrofurantoin 27 . A study Ali, Shamshad, et al, they isolated 100 Enterococcus species where 81 isolates (81%) showed to be sensitive to nitrofurantoin 33 .…”

Section: Discussionmentioning

confidence: 99%

The Study Of Invitro Susceptibility Of Vancomycin, Fosfomycin And Nitrofurantoin Among Urinary Isolates Of Enterococci

Harithaa¹,

Sujatha²,

Satyasai.B³

et al. 2022

Journal of Pharmaceutical Negative Results

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Background and objective: Enterococcus species are a common nosocomial pathogen that are gaining resistance to multiple drugs. Thepresent study aims to determine the prevalence of Vancomycin resistant enterococci and susceptibility pattern of urinary isolates ofEnterococci against different antimicrobials and special emphasis on urinary antimicrobial nitrofurantoin and Fosfomycin.Materials and Methods: In the present study, a total of 80 isolates of Enterococci were isolated from urine sample. The antibioticsusceptibility testing was determined for antimicrobials by Kirby-Bauer disc diffusion method. The results were interpreted according toCLSI guidelines, comparative evaluation of vancomycin susceptibility was done by disc diffusion and automated VITEK2 system.Results: 42 isolates were identified as E. faecalis and 38 isolates were identified as E. faecium by VITEK 2. 95% of the Enterococcalstrains were sensitive to Fosfomycin and 65% were sensitive to nitrofurantoin. Among 80 enterococcal isolates, 10 isolates wereidentified as Vancomycin-resistant Enterococci (VRE) by both VITEK2 and disc diffusion. All VRE isolates were found to be sensitiveto Fosfomycin and 50% of VRE isolates showed to be sensitive to nitrofurantoin.Conclusion: Our study showed that Fosfomycin had a good invitro activity for both Enterococci and VRE when compared toNitrofurantoin and other drugs. Vancomycin susceptibility detected by VITEK 2 and by disk diffusion showed good (100%) categoricalagreement.

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“…Several studies in India have reported around 95% sensitivity for Fosfomycin and also reported its utility in MDR E. coli. 5,37,38,57 Studies across different countries shows nearly 85-100% susceptibility to fosfomycin and minimal propensity for collateral damage. 14,40,41,58 In our series, we found 100% sensitivity for fosfomycin due to this drug not being in common therapeutic use.…”

Section: Discussionmentioning

confidence: 99%

Predisposition of Blood group Non-secretors to Urinary tract infection with Escherichia coli Anti-microbial Resistance and Acute Kidney Injury

Thiagarajan¹,

Spellman²,

Kanagamuthu³

et al. 2021

J. Pure Appl. Microbiol.

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Urinary tract infection (UTI) causes significant renal damage and disease severity is compounded by antimicrobial resistance (AMR) and other comorbidities in the patient. Blood group antigens secreted in body fluids (secretor status) are known to play a role in bacterial adhesion and we studied its influence on AMR in UTI. A total of 2758 patients with UTI were studied with urine culture, qualitative and semiquantitative urine microscopy, serum creatinine and secretor status in saliva samples by adsorption-inhibition method. Of these, AMR from 300 patients with E. coli infection were assessed as per CLSI 2019 guidelines and extended-spectrum beta-lactamase (ESBL) genes (bla TEM, bla CTX-M, bla SHV) and NDM1 genes were studied using TaqMan probes in Real-time polymerase chain reaction. Patients with UTI were followed up for two weeks. Female patients had higher predilection (57%) for E. coli infection while patients with diabetes or non-secretors had none. In our study, ESBL producers were seen in 62% of the E. coli isolates and fosfomycin had 100% susceptibility. Non-secretors were significantly associated with acute kidney injury (AKI), AMR and ESBL genes. Multidrug-resistant (MDR) was noted in 127/160 (79.4%) ESBL and 17/18 (94%) NDM1 gene encoding strains. Quantitative urine microscopy scoring predicted AKI both at presentation and at end of follow up. ESBL producers were common in our study population and non-secretors had a significant association with AMR genes. Urine microscopy scoring system may be a useful tool to predict AKI in patients with UTI.

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Evaluation of in vitro susceptibility of fosfomycin among Enterobacteriaceae isolates from urine cultures: A study from Puducherry

Cited by 11 publications

References 17 publications

Antibiotic resistance in uropathogenic enterobacteria

Antibiotic resistance in uropathogenic enterobacteria

The Study Of Invitro Susceptibility Of Vancomycin, Fosfomycin And Nitrofurantoin Among Urinary Isolates Of Enterococci

Predisposition of Blood group Non-secretors to Urinary tract infection with Escherichia coli Anti-microbial Resistance and Acute Kidney Injury

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