Evaluation of in vivo acute immunotoxicity of a major organic arsenic compound arsenobetaine in seafood

Sakurai, Takeshi; Kojima, Chikara; Ochiai, Masayuki; Ohta, Takami; Fujiwara, Kitao

doi:10.1016/j.intimp.2003.11.004

Cited by 43 publications

(20 citation statements)

References 21 publications

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“…Inorganic arsenic is considered carcinogenic and is related mainly to lung, kidney, bladder, and skin disorders (ATSDR, 2003a). The toxicity of arsenic in its inorganic form has been known for decades under the following forms: acute toxicity, subchronic toxicity, genetic toxicity, developmental and reproductive toxicity (Chakraborti et al, 2004), immunotoxicity (Sakurai et al, 2004), biochemical and cellular toxicity, and chronic toxicity (Mudhoo et al, 2011;Schwarzenegger et al, 2004). Drinking water is one of the primary routes of exposure of inorganic arsenic (Mudhoo et al, 2011;National Research Council, 2001).…”

Section: Arsenicmentioning

confidence: 99%

Heavy Metals and Human Health

Morais¹,

Costa²,

Pereira³

2012

Environmental Health - Emerging Issues and Practice

233

136

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Section: Arsenicmentioning

confidence: 99%

Heavy Metals and Human Health

Morais¹,

Costa²,

Pereira³

2012

Environmental Health - Emerging Issues and Practice

233

136

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“…Other cancers liked to arsenic toxicity include kidney and bladder [30]. The toxicity of arsenic and its inorganic compounds has been classified as: acute toxicity, sub-chronic toxicity, genetic toxicity, developmental and reproductive toxicity [31], immunotoxicity [32], biochemical and cellular toxicity [33]. It has also been reported that arsenic-induced oxidative stress causes DNA strand breaks; an alkali-labile sites which eventually results into DNA adducts [34].…”

Section: Pollution Indexesmentioning

confidence: 99%

Survey of the Levels of some Heavy Metals in Roadside Dusts along Katima Mulilo Urban Road Construction, Namibia

Abah¹

2014

AJEP

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Abstract:Roadside dusts pollutions with heavy metals continue to attract attention as more anthropogenic activities including urban road construction impacted on the natural metal loads of the environment. This study employed analytical procedures to investigate the concentrations of arsenic, lead, chromium, cadmium, cobalt, copper, nickel, manganese, vanadium, iron and tin in the roadside dusts along Katima Mulilo urban road construction. Replicate dusts samples collected from three different areas of the road and a quiet residential area (control) were digested by EPA method 3050B followed by Inductively Coupled Plasma-Optical Emission Spectrophotometer (ICP: Perkin Elmer Optima 7000 DV) analysis. The results of levels of the heavy metals revealed that iron recorded the highest concentration of 7491.13±0.15 mg/kg along the road construction while tin recorded the lowest value (0.27±0.13 mg/kg). Similar trend was observed at the control area located 1.5 km away from the road: iron recorded the highest concentration of 2327.17±0.12 mg/kg while tin recorded the lowest concentration (0.20±0.10 mg/kg). The analysis of variance of the heavy metal concentrations across the sample locations were statistically significant (p > 0.05). However, the levels of the heavy metals recorded cross the sampling areas were less than their soil maximum permissible concentrations. There are strong positive inter-elemental correlations between the sampling areas while result of the soil enrichment factors showed significant enrichment; which are related to common and input from anthropogenically induced sources respectively. The results of single element pollution indexes of the heavy metals showed low contaminations but elevated levels of arsenic and cadmium in all the sampling areas. These could become a potential source of health concern following environmental accumulation and non-biodegradation of the heavy metals. Thus, it is recommended among others that an environmental impact assessment should be carried out on gravel sites to be used in urban road construction to limit heavy metal contaminations of roadside dusts following their usage.

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“…Arsenic is not considered a direct mutagen; nevertheless, it may increase DNA damage and mutation indirectly by altering DNA repair machinery (Andrew et al, 2003(Andrew et al, , 2006. Several studies have demonstrated that arsenic is an immunotoxic compound (Burns and Munson, 1993;Hall, 2002;Soto-Peña et al, 2006;Patterson et al, 2004;Sakurai et al, 2004Sakurai et al, , 2006. Arsenic was also shown to cross the placental barrier (Concha et al, 1998;Golub et al, 1998), extending the risk of toxicity to the foetus (Jin et al, 2006;Waalkes et al, 2007).…”

Section: Introductionmentioning

confidence: 99%