Evaluation of in-vivo antiarthritic potential of methanolic extract of Costus speciosus rhizome

Kala, Chandra; Ali, Syed Salman; Abid, Mohd; Sharma, Uma S.; Khan, Najam Ali

doi:10.7324/japs.2015.50808

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…Drug was administered orally to overnight fasted rat sat a volume of 1 ml/100 g body weight. Erdosteine was dissolved in DMSO and was administered at a single dose of 2000 mg/kg [17] in Group B and tap water was administered to (Fig. 2) Group A and food was withheld for another 3 h. They were observed continuously for 4 h for behavioral and autonomic profiles and regularly for the first critical 24 h and daily for a total of 14 days for any lethality.…”

Section: Acute Oral Toxicity Studymentioning

confidence: 99%

Erdosteine: An Effective Antioxidant for Protecting Complete Freund’s Adjuvant Induced Arthritis in Rats

Synmon¹,

Roy²,

Majee³

et al. 2021

Asian J Pharm Clin Res

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Objective: The objective of this study was to evaluate the protective effect of Erdosteine on complete freund’s adjuvant (CFA) induced arthritic rats. Methods: Wistar Albino rats of 100–250 g were divided into five groups (n=6) and administered with 0.1 ml of CFA subcutaneously into the left hind paw except the negative control group. The standard group received methotrexate (MTX) 0.075 mg/kg body weight orally. Besides, the test groups received Erdosteine orally at a dose 10 mg/kg and 20 mg/kg bodyweight for 12 days. The changes in body weight, paw volume, hematological parameters, radiographical, and histological findings were the indicators to evaluate the efficacy of the test product. Discussion: Significant change in the body weight, paw volume, radiographical, hematological, and histological parameters were observed which supports the remarkable reduction of the arthritic development in the standard and test groups compared to the untreated group. However, the test group (Erdosteine) with the dose 20 mg/kg shows to be more potent than the test group (Erdosteine) with a dose 10 mg/kg and the standard group (MTX) to reduce the arthritic effect. Results: The test group with 20 mg/kg Erdosteine showed much better outcome than the standard group at significant (p<0.05). Therefore, Erdosteine acting as an anti-inflammatory and anti-oxidant is effective at a dose 20 mg/kg in treating the progression of rheumatoid arthritis in rats.

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Section: Acute Oral Toxicity Studymentioning

confidence: 99%

Erdosteine: An Effective Antioxidant for Protecting Complete Freund’s Adjuvant Induced Arthritis in Rats

Synmon¹,

Roy²,

Majee³

et al. 2021

Asian J Pharm Clin Res

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“…In another study [12], Animal Wistar albino rat (150-200 g) of either sex. Optimum condition-temperature -25°C±0.5°C Relative humidity -55-65.…”

Section: Plant Detailsmentioning

confidence: 99%

“…Here, in the study, they showed that plant has ability to decrease the TNF-α level. Hence, we may say that the plant has immunosuppressive effect [12].…”

Section: Plant Detailsmentioning

confidence: 99%

Costus Speciosus and Its Antipsoriatic Arthritis Activity: A Review

Chakraborty

Yolmo

2019

Asian J Pharm Clin Res

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Objective: Psoriatic arthritis is an autoimmune disease. The marketed drugs cannot totally cure the disease state as well as they have severe side effects and for that reason researcher and scientists are going for traditional medicines. Costus speciosus is the plant of choice for its several positive activities against psoriatic arthritis.Methods: Wistar albino healthy rat was taken for 0.1 ml of Freund adjuvant-induced anti-arthritic and anti-inflammatory test, and diclofenac sodium (15 mg/kg) was taken as standard drug. The paw volume was measured at different time 1st, 7th, 14th, and 21st days of experiment. In another study, the protocol is same, but indomethacin (10 mg/kg) was taken as standard drug. Another study was performed to know that the plant drug has any lipopolysaccharide (LPS)-stimulated COX-protein inhibitor activity or not. An acute anti-inflammatory property was studied in carrageenan-induced paw edema and result is measured by plethysmometer. The chronic anti-inflammatory property was studied by cotton pellet-induced granuloma formation. 400 mg/kg and 800 mg/kg dose of ethanolic extract is administered to the animal of both acute and chronic studies.Results: In anti-arthritic and anti-inflammatory study, after the 21st day, it has found that standard drug (diclofenac sodium) decreases paw volume 40 % where the plant drug reduces it 68.33% & 75.50% at higher and lower dose respectively. In the other study the Standard drug (Indomethacin) show arthritic score of 0.83 and the extract shows 1.67 at its higher concentration. In LPS-stimulated cyclooxygenase-2 (COX-2) inhibition study, extract helps to decrease the LPS-stimulated COX-2 protein nearly similar as methotrexate without any side effect. In the cotton pallet-induced anti-inflammatory study, 400 mg/kg and 800 mg/kg dose of ethanolic extract shows similar result against standard drug.Conclusion: Although its activity is less compared to the marketed drug, in the other sides, it has very mild adverse effect compared to the marketed Drug. It can be used as a supportive drug in the treatment of Psoriatic arthritis and by chemical modification the activity may be increased without any side effect.

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“…After 6 hours of test administration the animals weighed again. A careful clinical examination was made once in each day for next 14days (OECD 4/26, 2006) [9].…”

Section: Acute Oral Toxicity Study (Ld50)mentioning

confidence: 99%

Immunomodulatory Activity of Methanolic Extract of Drypetes Roxburghii Leaves

Kala¹

2017

GJPPS

Self Cite

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Putranjiva roxburghii Wall (syn. Drypetes roxburghii Wall.) is an evergreen tree of tropical region belonging to family Euphorbiaceae family [6]. The leaves are reported to contain β-amyrin and its esters, putrone, putrol, putranjivic acid, methyl putrajivate, stigmasterol and hydrocarbons, triterpene roxburghonic acid and biflavones [7]. Material and Methods ChemicalsEthanol, CMC, zinc sulphate, barium chloride and sulphuric acid (7664-93-9) were purchased from CDH, pvt ltd, New Delhi. Plant materialLeaves of Drypetes roxburghii was procured and authenticated from NBRI, Lucknow Extraction and fractionationThe leaves were dried in shade at room temperature. The dried leaves were powdered by using grinder to coarse powder, packed into Soxhlet column and the extracted 70% ethanol for

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Evaluation of in-vivo antiarthritic potential of methanolic extract of Costus speciosus rhizome

Cited by 5 publications

References 11 publications

Erdosteine: An Effective Antioxidant for Protecting Complete Freund’s Adjuvant Induced Arthritis in Rats

Erdosteine: An Effective Antioxidant for Protecting Complete Freund’s Adjuvant Induced Arthritis in Rats

Costus Speciosus and Its Antipsoriatic Arthritis Activity: A Review

Immunomodulatory Activity of Methanolic Extract of Drypetes Roxburghii Leaves

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