Evaluation of in vivo antioxidant potential of Syzygium jambos (L.) Alston and Terminalia citrina Roxb. towards oxidative stress response in Saccharomyces cerevisiae

Rajkumari, Jobina; Dyavaiah, Madhu; Siddhardha, Busi

doi:10.1007/s13197-018-3355-z

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…The ROS model has been well studied at present, mainly because ROS production promotes the dissociation between thioredoxin in cells and its ligand in Txnip, the latter of which may bind to NLRP3 and lead to its activation (37). Oxidative stress is caused by the imbalance between antioxidants and ROS, and its effect of promoting AS has been widely recognized (38). Studies have demonstrated that ROS significantly promotes the occurrence and development of AS (39,40).…”

Section: Discussionmentioning

confidence: 99%

Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles

Xiao¹,

Shang²,

Sun³

2019

Exp Ther Med

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Effect of tacrolimus on atherosclerotic plaques and its influence on Nod-like receptor protein 3 (NLRP3) inflammatory pathway were studied by establishing the mouse model of atherosclerosis. The mice were divided into 3 groups: C57BL/6 mouse group (WT group), ApoE-/mouse group (ApoE-/group) and ApoE-/mouse + tacrolimus intervention group (ApoE-/-+ Tac group). The area of atherosclerotic plaques and the pathological morphologic changes were observed. The NLRP3, interleukin-1β (IL-1β), IL-18, NLRP3 inflammatory corpuscles, pro-inflammatory factors IL-1β and IL-18 in the aorta were analyzed. The area of atherosclerotic plaques in ApoE-/mice was increased significantly, and it was significantly reduced after tacrolimus intervention. After tacrolimus intervention, the arterial intima became obviously thinner and no obvious cholesterol crystals were observed. The macrophage infiltration in atherosclerotic plaques was significantly increased, and the content of smooth muscle cells was also increased. The levels of serum IL-1β, IL-18 and NLRP3 in ApoE-/mice were significantly increased, and they remarkably declined after tacrolimus intervention. ROS content in atherosclerotic plaques was increased in ApoE-/mice, and it remarkably declined after tacrolimus intervention. The protein content of NLRP3, ASC, Casp-1, IL-1β and IL-18 in the aorta in ApoE-/mice was remarkably increased, and they were inhibited to some extent after tacrolimus intervention. In conclusion, it is speculated that tacrolimus may reduce the formation of AS through inhibiting ROS in macrophages and activation of NLRP3 inflammatory corpuscles and reducing the release of IL-1β and IL-18.

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Section: Discussionmentioning

confidence: 99%

Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles

Xiao¹,

Shang²,

Sun³

2019

Exp Ther Med

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“…Terminalia bellirica, Terminalia citrina, Tinospora crispa, and Zingiber officinale. All its herbal components, except for Maerua siamensis, have been found to act as free radical scavengers, [29][30][31][32][33][34][35][36] © 2021 the authors. This work is licensed under the Creative Commons Attribution 4.0 International License thereby playing the main role in the reactive oxygen species scavenging activities of Phy-Blica-O.…”

Section: Preliminary Antioxidant Activity Resultsmentioning

confidence: 99%

“…Among these, the administration of extracts obtained from Allium sativum, Zingiber officinale, Piper retrofractum, Terminalia citrina, Terminalia bellirica, Phyllanthus emblica, Tinospora crispa, or Terminalia arjuna has been found to attenuate the antioxidant status in animal models. 31,34,35,[37][38][39][40][41][42] Clinical studies have also revealed that Phyllanthus emblica or Terminalia arjuna consumption significantly changes the oxidative stress biomarkers in patients. 43,44 Although Phy-Blica-O is made by combining equal amounts of the medicinal plant, it is likely that Phyllanthus emblica and Terminalia arjuna were its active ingredients, according to the evidence mentioned above…”

Section: Preliminary Antioxidant Activity Resultsmentioning

confidence: 99%

Antioxidant and Lifespan-Extending Effects of a Rejuvenating Thai Traditional Polyherbal Remedy (Phy-Blica-O) in Caenorhabditis elegans

2021

TJNPR

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Facing rapid growth in the aging global population, chronic age-related diseases such as dementia, cancer, cardiovascular disease, and diabetes are becoming some of the most significant threats to society, creating huge medical and socioeconomic burdens. 1,2 For example, in the United States, national spending on cancer is projected to be almost $160 billion in 2020, 2 whereas the total national costs of health care for dementia, including Alzheimer's disease, are estimated at $305 billion for 2020. The prevalence of Alzheimer's disease is expected to increase to 13 million by 2050. 3 Aging is an inevitable progressive decline in tissue integrity and body functions with age. This description is based on several published theories, including the free radical theory of aging. 4,5 Despite the well-accepted notion that oxidative damage increases with age, a reduction in oxidative damage has been proven to extend the lifespan of various model organisms. 6

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“…This approach may lead to reduced pathogenicity of pathogens and a reduction in the development of resistance (Silva et al, 2016). Indeed, the ability of a pathogenic bacterium to form biofilm communities and to move across surfaces is very important for virulence determination (Kearns, 2010;Rajkumari et al, 2018b). Interestingly, our extract at sub-inhibitory concentrations (1/ 8 MIC = 12.5 mg/mL and 1/4 MIC = 25 mg/mL) significantly reduced the amount of the biofilm produced with inhibition percentages of 41.17% and 88.23%, respectively (Figure 10B).…”

Section: Antibacterial Activitiesmentioning

confidence: 99%

Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments

Mahdi,

Imbimbo,

Ortaakarsu

et al. 2024

Front. Mol. Biosci.

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The phytoconstituents of the aqueous extract from Syzygium jambos L. (Alston) leaves were defined using HPLC-PDA-MS/MS and the antioxidant, anti-aging, antibacterial, and anti-biofilm activities of the extract were in silico and in vitro investigated. The antioxidant activities were performed using in vitro DPPH and FRAP assays as well as H2-DCFDA assay in HaCaT cells in which oxidative stress was induced by UVA radiation. Anti-aging activity was tested in vitro, using aging-related enzymes. The antibacterial, anti-biofilm and inhibitory effects on bacterial mobilities (swarming and swimming) were assessed against Pseudomonas aeruginosa. Results showed that S. jambos aqueous extract contained 28 phytochemicals belonging to different metabolite classes, mainly phenolic acids, gallic acid derivatives, flavonoids, and ellagitannins. Mineral content analysis showed that S. jambos leaves contained moderate amounts of nitrogen, potassium, manganese, magnesium, and zinc, relatively low amounts of phosphorus and copper, and high concentration of calcium and iron. The extract displayed strong antioxidant activities in vitro and inhibited UVA-induced oxidative stress in HaCaT cells. Docking the major compounds identified in the extract into the four main protein targets involved in skin aging revealed an appreciable inhibitory potential of these compounds against tyrosinase, elastase, hyaluronidase, and collagenase enzymes. Moreover, molecular dynamic simulations were adopted to confirm the binding affinity of some selected compounds towards the target enzymes. The extract exhibited pronounced in vitro anti-aging effects, compared to kojic acid and quercetin (the reference compounds). It also inhibited the growth of P. aeruginosa, counteracted its ability to form biofilm, and impeded its swarming and swimming mobilities. Altogether, these findings strongly propose S. jambos leaves as a promising source of bioactive metabolites for the development of natural cosmeceutical and dermatological agents.

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Evaluation of in vivo antioxidant potential of Syzygium jambos (L.) Alston and Terminalia citrina Roxb. towards oxidative stress response in Saccharomyces cerevisiae

Cited by 9 publications

References 28 publications

Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles

Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles

Antioxidant and Lifespan-Extending Effects of a Rejuvenating Thai Traditional Polyherbal Remedy (Phy-Blica-O) in Caenorhabditis elegans

Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments

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