Evaluation of inductively heated ferromagnetic alloy implants for therapeutic interstitial hyperthermia

Paulus, J.A.; Richardson, J.S.; Tucker, Robert D.; Park, J.B.

doi:10.1109/10.486260

Cited by 39 publications

(18 citation statements)

References 15 publications

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“…Furthermore, there are no limitations of efficacy due to reflection and absorption phenomena, which can be encountered in deep regional hyperthermia using microwave or ultrasound techniques [20]. Thermally self-regulating ferromagnetic seeds have been developed for hyperthermia and investigated by several groups [21,22]. Deger et al [2] conducted a phase II-study using cobalt-palladium-thermoseeds, which were permanently implanted into the prostate.…”

Section: Discussionmentioning

confidence: 99%

Clinical hyperthermia of prostate cancer using magnetic nanoparticles: Presentation of a new interstitial technique

Johannsen

Gneveckow

Eckelt

et al. 2005

International Journal of Hyperthermia

721

479

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The aim of this pilot study was to evaluate whether the technique of magnetic fluid hyperthermia can be used for minimally invasive treatment of prostate cancer. This paper presents the first clinical application of interstitial hyperthermia using magnetic nanoparticles in locally recurrent prostate cancer. Treatment planning was carried out using computerized tomography (CT) of the prostate. Based on the individual anatomy of the prostate and the estimated specific absorption rate (SAR) of magnetic fluids in prostatic tissue, the number and position of magnetic fluid depots required for sufficient heat deposition was calculated while rectum and urethra were spared. Nanoparticle suspensions were injected transperineally into the prostate under transrectal ultrasound and flouroscopy guidance. Treatments were delivered in the first magnetic field applicator for use in humans, using an alternating current magnetic field with a frequency of 100 kHz and variable field strength (0-18 kA m À1). Invasive thermometry of the prostate was carried out in the first and last of six weekly hyperthermia sessions of 60 min duration. CT-scans of the prostate were repeated following the first and last hyperthermia treatment to document magnetic nanoparticle distribution and the position of the thermometry probes in the prostate. Nanoparticles were retained in the prostate during the treatment interval of 6 weeks. Using appropriate software (AMIRA), a non-invasive estimation of temperature values in the prostate, based on intra-tumoural distribution of magnetic nanoparticles, can be performed and correlated with invasively measured intra-prostatic temperatures. Using a specially designed cooling device, treatment was well tolerated without anaesthesia. In the first patient treated, maximum and minimum intraprostatic temperatures measured at a field strength of 4.0-5.0 kA m À1 were 48.5 C and 40.0 C during the 1st treatment and 42.5 C and 39.4 C during the 6th treatment, respectively. These first clinical experiences prompted us to initiate a phase I study to evaluate feasibility, toxicity and quality of life during hyperthermia using magnetic nanoparticles in patients with biopsy-proven local recurrence of prostate cancer following radiotherapy with curative intent. To the authors' knowledge, this

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Section: Discussionmentioning

confidence: 99%

Clinical hyperthermia of prostate cancer using magnetic nanoparticles: Presentation of a new interstitial technique

Johannsen

Gneveckow

Eckelt

et al. 2005

International Journal of Hyperthermia

721

479

View full text Add to dashboard Cite

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“…At present, where induction heating techniques are concerned, it is possible to find only initial studies in recent literature (STAUFFER et al, 1984, TOMPKINS et al, 1994PAULUS et al, 1996;SATO et al, 1993;ATKINSON, 1984).…”

Section: Introductionmentioning

confidence: 99%

Numerical simulation of thermal disposition with induction heating used for oncological hyperthermic treatment

Dughiero

Corazza

2005

Med. Biol. Eng. Comput.

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Hyperthermia plays an important role in oncological therapies, most often being used in combination with radiotherapy, chemotherapy and immunotherapy. The success of this therapy is strongly dependent on the precision and control of thermal deposition. Hyperthermia based on induction heating, with thermally self-regulating thermoseeds inserted into the tumorous mass, is used for interstitial treatment. The technique was the subject of the numerical study presented in the paper. The analysis was carried out using coupled electromagnetic heating and thermo-fluid dynamic FEM simulations. During thermal deposition by induction heating of inserted seeds, the simulations estimated the thermal field inside and outside the tumour, as well as the sensitivity of the thermal field to variations regarding seed temperature, configuration and proximity to vessels. The method, for which accurate anatomical patient's information is essential, is suitable for providing useful qualitative and quantitative information about thermal transients and power density distribution for hyperthermic treatment. Several grid steps were analysed and compared. A 1 cm seed grid was resulted in good homogeneity and effectiveness of the thermal deposition. The cold spot effect caused by large vessels was demonstrated and quantified. Simulations of the heating of a tumorous mass in the liver showed that an indcutor generator operating at 200 kHz frequency and 500 A current, producing a pulsating magnetic field of H = 60 A cm(-1), was adequate for the treatment. The seeds that perform best among those tested (Nicu (28% Cu), PdNi (27.2% Ni), PdCo (6.15% Co) and ferrite core) were the PdNi (1 mm radius, 10 mm length), as they have a low Curie temperature (52 degrees C), which is the closest to the desired treatment temperature and thus reduces the risk of hot spots.

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“…Basic research mainly focused on heat generation by different materials (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33), thermoseed processing methods (34,35), heating coil designs (36,37), improving uniform temperature distribution (38)(39)(40)(41)(42)(43)(44)(45)(46)(47), and the in vivo effects on animals (12,21,25,28,30,32,33,36,38,41,(48)(49)(50)(51). Clinical research mainly focused on intracranial tumors (52,53), prostate cancer (54)(55)(56)57), and some other tumors …”

Section: Discussionmentioning

confidence: 99%

Feasibility study of high-temperature thermoseed inductive hyperthermia in melanoma treatment

Xia

Li²,

Zhao³

et al. 2011

Oncol Rep

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Abstract. Current treatment modalities for melanoma do not offer satisfactory efficacy. We have developed a new, minimally invasive hyperthermia technology based on radio-frequency hyperthermia. Herein, we investigated the feasibility of using a nickel-copper thermoseed for inductive hyperthermia at a relatively high temperature (46-55˚C). In vitro, the thermoseed showed good thermal effects and effective killing of B16/F10 melanoma cells. Temperatures of 53.1±0.5˚C were achieved for a single thermoseed and 56.5±0.5˚C for two in parallel (spacing 5 mm). No B16/F10 melanoma cells survived with heating time longer than 20 min in the parallel thermoseed group. Magnetic fields or thermoseeds alone did not affect the survival rate of B16/F10 cells (P>0.05). In vivo, B16/F10 melanoma cells were subcutaneously injected into the right axilla of C57BL/6 mice. After the tumors grew to ~11-13 mm, two thermoseeds (spacing 5 mm) were implanted into the tumors and the mice were subjected to an alternating magnetic field (100-250 kHz, 15 kA/m) to induce hyperthermia. The temperature at the center of the tumor reached 46˚C at 5 min and plateaued at 50˚C. Thermoseed treatment produced large necrotic areas, inhibited tumor growth in 60% (6 of 10) of animals and prolonged survival time (P<0.05). Thus, with further optimization and testing, high-temperature thermoseed inductive hyperthermia may have therapeutic potential for melanoma.

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Evaluation of inductively heated ferromagnetic alloy implants for therapeutic interstitial hyperthermia

Cited by 39 publications

References 15 publications

Clinical hyperthermia of prostate cancer using magnetic nanoparticles: Presentation of a new interstitial technique

Clinical hyperthermia of prostate cancer using magnetic nanoparticles: Presentation of a new interstitial technique

Numerical simulation of thermal disposition with induction heating used for oncological hyperthermic treatment

Feasibility study of high-temperature thermoseed inductive hyperthermia in melanoma treatment

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