Evaluation of inhomogeneities of repolarization in patients with psoriasis vulgaris

Abstract

IntroductionThe arrhythmia potential has not been investigated adequately in psoriatic patients. In this study, we assessed the ventricular repolarization dispersion, using the Tp-e interval and the Tp-e/QT ratio, and investigated the association with inflammation.Material and methodsSeventy-one psoriasis vulgaris patients and 70 age- and gender-matched healthy individuals were enrolled in the study. The severity of the disease was calculated using Psoriasis Area and Severity Index scoring. The QTd was defined as the difference between the maximum and minimum QT intervals. The Tp-e interval was defined as the interval from the peak of the T wave to the end of the T wave. The Tp-e interval was corrected for heart rate. The Tp-e/QT ratio was calculated using these measurements.ResultsThere were no significant differences between the groups with respect to basal clinical and laboratory characteristics (p > 0.05). The Tp-e interval, the corrected Tp-e interval (cTp-e) and the Tp-e/QT ratio were also significantly higher in psoriasis patients compared to the control group (78.5 ±8.0 ms vs. 71.4 ±7.6 ms, p < 0.001, 86.3 ±13.2 ms vs. 77.6 ±9.0 ms, p < 0.001 and 0.21 ±0.02 vs. 0.19 ±0.02, p < 0.001 respectively). A significant correlation was detected between the cTp-e time and the Tp-e/QT ratio and the PASI score in the group of psoriatic patients (r = 0.51, p < 0.001; r = 0.59, p < 0.001, respectively).ConclusionsIn our study, we detected a significant increase in the Tp-e interval and the Tp-e/QT ratio in patients with psoriasis vulgaris. The Tp-e interval and the Tp-e/QT ratio may be predictors for ventricular arrhythmias in patients with psoriasis vulgaris.

Evaluation of ventricular repolarization features with novel electrocardiographic parameters (Tp-e, Tp-e/QT) in patients with psoriasis

“…A recent study showed that QTd was significantly higher in patients with psoriasis ( 27 ). Also, Soylu et al ( 28 ) recently reported that QT and QTc intervals were increased in patients with psoriasis compared with control subjects, similar to the results of our study.…”

“…Previous studies have indicated that some chronic inflammatory diseases, including rheumatoid arthritis and ankylosing spondylitis, are associated with an increased Tp-e interval and Tp-e/QT ratio ( 30 , 31 ). Recently, Soylu et al ( 28 ) reported that Tp-e and Tp-ec intervals and the Tp-e/QT ratio were higher in patients with psoriasis. Likewise, in our study, we found that Tp-e and Tp-ec intervals and the Tp-e/QT ratio were increased in patients with psoriasis compared with control subjects.…”

P wave dispersion, Tpeak–Tend interval, and Tp-e/QT ratio in children with psoriasis

“…Recent studies indicate that the Tp-e interval and Tp-e/QT ratio can be used as an index of transmural dispersion of repolarisation. [10][11][12] In our study, we demonstrated that QTc max, QTc dis, Tp-e interval, and Tp-e/QTc max ratio were significantly prolonged in psoriasis patients (Table 2). Also, we found that Pdis had a positive correlation with QTc max (Table 3).…”

Abnormal serum fatty acid profile in psoriatic arthritis

“…Furthermore, low serum concentration of n-3 PUFA in psoriasis with higher PASI, found in our group of PsA patients, may be associated with enhanced inflammation and it may play a role in the development of comorbidity. Several epidemiological studies have confirmed a strong association of moderate to severe psoriasis with cardiometabolic disorders including obesity, type 2 diabetes, dyslipidemia and metabolic syndrome, hypertension and arrhythmia [38, 39]. A diet enriched in n-3 PUFA ameliorates metabolic markers and clinical outcome in psoriatic patients with obesity [36].…”