Evaluation of injectable platelet-rich fibrin produced by a simple twice-centrifugation method combined with vacuum sealing drainage technology in the treatment of chronic refractory wounds

Xue, Xin; Bian, Yuling; Meng, Yonggang; Wei, Wei; Meng, Lingmin; Zhang, Qingfu; Tao, Jianguang

doi:10.3389/fbioe.2022.979834

Cited by 6 publications

(1 citation statement)

References 31 publications

(20 reference statements)

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“…This gel acquires properties that allow an even slower absorption into the tissue, serving as a more enduring scaffold to keep the platelets and leukocytes at the desired location and optimise the delivery of growth factors to the injured tissue. While PRP and PRF focus on the concentration and delivery of regenerative factors, the gel form adds a structural dimension to the treatment, potentially enhancing the efficacy of regenerative therapy [18][19][20][21][22][23][24].…”

Section: Original Research Articlementioning

confidence: 99%

Comparative Study on the Efficacy of Injectable Platelet Rich Fibrin (i-PRF) and Albumin Gel (ALB-Gel) in Facial Rejuvenation: A Clinical Ultrasonographic Evaluation

Garcia,

Brodt,

Marchi

et al. 2024

JAMMR

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Cutaneous ageing is a natural process associated with advancing age, potentially resulting in negative consequences on individuals' self-esteem. The primary manifestations of this process are the emergence of wrinkles, spots, dehydration, sagging, and loss of tissue vitality. In recent years, there has been a significant increase in the pursuit of more natural treatments for facial rejuvenation. In this context, using ALB-Gel and i-PRF stands out as a biological and autologous material. Materials and Methods: The measurement of the dermis using a 16 MHz ultrasound device and photographic documentation allowed for evaluating the technique's efficacy in reducing signs of ageing and nasolabial fold depth. The clinical study was conducted with 13 female participants aged 35 to 55 who underwent a session of ALB-Gel and i-PRF application in the right hemiface nasolabial fold region and i-PRF in the left hemiface. A paired t-test with a significance level of 5% was used in the statistical analysis. The scores on the Self-Perception Index were also statistically assessed using the Wilcoxon test at 5% to verify significant improvement. Additionally, new frontal and profile D and E photos were taken and compared with the initial images. Results: For the right hemiface nasolabial fold, a P < 0.0074 was observed to compare initial and final signs; for the left hemiface, a P < 0.1259 was obtained. These statistical results evidence a significant increase in dermal thickness in the right hemiface nasolabial fold (D) region after intradermal application of ALB-Gel and i-PRF; in the left hemiface nasolabial fold (E) region, treated only with i-PRF, no significant change in dermal thickness was observed. The statistical analysis conducted for the Self-Perception Index revealed a P < 0.0001, indicating a highly significant improvement in participant perception post-treatment. Conclusion: The intradermal application of ALB-Gel and i-PRF in a single session significantly increased dermal thickness, indicating this is a simple and low-cost alternative for dermal restructuring.

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Section: Original Research Articlementioning

confidence: 99%

Comparative Study on the Efficacy of Injectable Platelet Rich Fibrin (i-PRF) and Albumin Gel (ALB-Gel) in Facial Rejuvenation: A Clinical Ultrasonographic Evaluation

Garcia,

Brodt,

Marchi

et al. 2024

JAMMR

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The Efficacy and Safety of Negative‐Pressure Wound Therapy Combined With Platelet‐Rich Plasma in Chronic Refractory Wounds: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Hao,

Luo,

Xiao

et al. 2024

Health Science Reports

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Background and AimsChronic refractory wound is a disease that seriously impairs the quality of life of patients. Negative pressure wound therapy and platelet‐rich plasma are commonly used to treat various types of wounds. Further research is necessary to explore the efficacy and safety of the combination of negative pressure wound therapy and platelet‐rich plasma in treating chronic refractory wounds.MethodsPubMed, Web of Science, EMBASE, Cochrane, CINAHL, CNKI, Sino Med, and Wanfang Med Online up until March 2024 were searched(PROSPERO No. CRD42024507963). Two investigators screened literature according to inclusion and exclusion criteria, evaluated bias and certainty of evidence using RoB 2.0 and GRADE. Stata 12.0 was used to analyze the data.ResultsA total of 35 randomized controlled trials involving 2495 participants were included. 34 studies were assessed as having some concerns, and 1 study as having high risk in the risk of bias assessment. The results of meta‐analysis showed that effective rate (RR1.23, 95% CI [1.17, 1.30], p < 0.001; I2 = 44.7%, p = 0.013), healing time (WMD‐9.32, 95% CI [−10.60, −8.03], p < 0.001; I² = 91.00%, p < 0.001), healing rate (RR1.76, 95% CI [1.50, 2.07], p < 0.001; I2 = 62.6%, p < 0.001), positive rate of bacterial(RR0.25, 95% CI [0.15, 0.40], p < 0.001; I² = 0%, p = 0.841), pain score (WMD‐1.43, 95% CI [−2.14, −0.72], p < 0.001; I² = 96.5%, p < 0.001), incidence of complications (RR0.45, 95% CI [0.30, 0.68], p < 0.001; I² = 46.3%, p = 0.098), length of hospital stay (WMD‐9.88, 95% CI [−13.42, 6.34], p < 0.001; I2 = 98.9%, p < 0.001), number of dressing changes (WMD‐2.56, 95% CI [−4.28, −0.83], p = 0.004; I² = 98.9%, p < 0.001), white blood cell level (WMD‐1.71, 95% CI [−2.00, −1.41], p < 0.001; I² = 33.9%, p = 0.195), c‐reactive protein level (WMD‐0.68, 95% CI [−1.04, −0.33], p < 0.001; I² = 88.8%, p < 0.001), erythrocyte sedimentation rate (WMD‐6.09, 95% CI [−8.05, −4.13], p < 0.001; I² = 13%, p = 0.32), score of vancouver scar scale (WMD‐1.78, 95% CI [−1.89, −1.66], p < 0.001; I² = 38.3%, p = 0.166) and preparation time of secondary repair (WMD‐4.95, 95% CI [−7.03, −2.87], p < 0.001; I² = 84.7%, p < 0.001) had statistically significant effects. However, hospitalization costs (WMD1423.56, 95% CI [−4588.93, 7436.06], p = 0.643; I2 = 100%, p < 0.001) had no significant difference.ConclusionsThis study demonstrates that the combination of negative‐pressure wound therapy and platelet‐rich plasma can improve the efficacy and safety on chronic refractory wounds. Optimal parameter combinations, elucidation of pathogenesis and treatment mechanisms can be explored in the future.

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Platelet Rich plasma injection of the vocal folds in benign vocal pathologies

Mackay,

Allen

2024

Eur Arch Otorhinolaryngol

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Purpose There are few options for treatment of dysphonia secondary to vocal pathology related to lamina propria scar, atrophy, sulcus, or inflammatory disorders. Platelet rich plasma (PRP) may provide anti-inflammatory and regenerative properties seen with other tissue engineering therapies without the risks associated with these treatments. We evaluated vocal fold (VF) injection of PRP for feasibility, phonatory effects, patient satisfaction and durability. Methods Patients with dysphonia secondary to vocal fold scar, atrophy, sulcus and inflammatory lesions were included. PRP injections were administered in office, to bilateral vocal folds. Patients were followed up at 1 week, 1 month, 3 months and 6 months to assess outcomes (GRBAS scale, maximum phonation time, vocal fatigue index (VFI), voice handicap index (VHI-10) and stroboscopy). Results 75 intracordal PRP injections were administered to 48 patients. All injections were completed, and no adverse reactions were experienced. Improvements in VHI-10 scores at 1,3,6 months were seen (mean VHI 21.73 at baseline, 15.62 at six months, p < 0.001). 72.3% rated improvement at 7 or above on Likert scale. 95.7% of patients would consider a future PRP injection. Secondary outcomes VFI, MPT, and GRBAS also demonstrated significant improvements over time. Patients receiving a single PRP injection (n = 26) still demonstrated significant VHI-10 improvements at 1,3 and 6 months. Conclusions VF office PRP injections are feasible and safe and can provide phonatory benefit and reduce vocal effort in benign VF disorders. A single PRP injection is sufficient to provide sustained benefit in some cases. Level of evidence Level III: prospective cohort study.

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Evaluation of injectable platelet-rich fibrin produced by a simple twice-centrifugation method combined with vacuum sealing drainage technology in the treatment of chronic refractory wounds

Cited by 6 publications

References 31 publications

Comparative Study on the Efficacy of Injectable Platelet Rich Fibrin (i-PRF) and Albumin Gel (ALB-Gel) in Facial Rejuvenation: A Clinical Ultrasonographic Evaluation

Comparative Study on the Efficacy of Injectable Platelet Rich Fibrin (i-PRF) and Albumin Gel (ALB-Gel) in Facial Rejuvenation: A Clinical Ultrasonographic Evaluation

The Efficacy and Safety of Negative‐Pressure Wound Therapy Combined With Platelet‐Rich Plasma in Chronic Refractory Wounds: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Platelet Rich plasma injection of the vocal folds in benign vocal pathologies

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