Evaluation of Insomnia and Daytime Napping in Iranian Alzheimer Disease Patients: Relationship With Severity of Dementia and Comparison With Normal Adults

Ohadinia, S.; Noroozıan, Maryam; Shahsavand, S.; Saghafi, Sharareh

doi:10.1176/appi.ajgp.12.5.517

Cited by 12 publications

(2 citation statements)

References 9 publications

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“…Additionally, studies have described an association between daytime napping and the severity of cognitive decline in AD patients and objective polysomnographic recordings confirm the relationship between minimental state examination and mean daytime sleep latency in mild/moderate AD patients. 75,76 However, some studies show discrepancies with those results. It has been recently reported that there is an absence of correlation between sleep score (Neuropsychiatric Inventory) and disease severity.…”

Section: Severity Of the Illnessmentioning

confidence: 87%

Sleep and Alzheimer’s Disease

et al. 2015

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Sleep architecture and sleep patterns normally change with aging. In preclinical Alzheimer's disease (AD), the accumulation of amyloid plaques begins 10 to 20 years before any cognitive symptoms progress. Soluble amyloid-β (Aβ) is secreted during physiological synaptic activity. Since synaptic activity is correlated with sleep and awake state, a degree of Aβ fluctuates in a diurnal sleep pattern. In animal and human studies, a degree of sleep quality showed a significant correlation with brain levels of Aβ and a risk of AD. Conversely, Aβ aggregation would debilitate neuronal function in brain regions critical to sleep and wake promotion. This bidirectional relationship can be explained as positive feedback loop and associated factors that influence this relationship. In AD, the degree of sleep disturbances is much more severe compared with in the normal elderly. Further, Sundowning syndrome and a reduction of melatonin level cause a stressful neuropsychiatric symptoms and a disruption of physiological sleep rhythm, respectively. In AD patients, a correlation between sleep architectural modifications and learning performances has been reported. Moreover, executive function and emotional reactivity might be attenuated by sleep disturbances, too. However, sleep disturbance does not impact cognitive functions of all patients with AD. This could support an individual and potentially genetically determined susceptibility. Sleep disturbances have an important effect on patients and caregivers. It has a critical value to confirm and treat individuals with sleep disorders and to explore whether good quality of sleep in humans can decrease the progression of preclinical to symptomatic AD.

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Section: Severity Of the Illnessmentioning

confidence: 87%

Sleep and Alzheimer’s Disease

et al. 2015

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“…There was a significant association between daytime sleep duration of 1 h or more and insomnia in older adults living in the community. 10 While the majority of studies have focused on the association between insomnia and cognitive impairment [6][7][8][9][10][11] and sleep disturbance in Alzheimer's disease, [18][19][20][21] investigation focused on the prevalence and risk factors of insomnia in older people with a mild to moderate degree of poor cognitive ability living in the community is currently scarce. Therefore, in the situation of the rapidly increasing number of older people, a community-based study which reveals the prevalence as well as the risk factors of insomnia will be valuable, either for general practitioners looking after this particular population at the outpatient clinic or national health policy makers to arrange an appropriate health promotion and insomnia prevention program in the community.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with insomnia in older people with a mild to moderate degree of poor cognitive ability in Thailand

Assantachai

Aekplakorn

Pattaraarchachai

et al. 2010

Geriatrics &Amp; Gerontology International

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Current awareness in geriatric psychiatry

2005

Int J Geriat Psychiatry

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Books, Reviews & Symposia; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Evaluation of Insomnia and Daytime Napping in Iranian Alzheimer Disease Patients: Relationship With Severity of Dementia and Comparison With Normal Adults

Cited by 12 publications

References 9 publications

Sleep and Alzheimer’s Disease

Sleep and Alzheimer’s Disease

Factors associated with insomnia in older people with a mild to moderate degree of poor cognitive ability in Thailand

Current awareness in geriatric psychiatry

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