Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome

Gül, Özen Öz; Cander, Soner; Gül, Bülent; Acikgoz, Ebru; Sarandöl, Emre; Ersoy, Canan

doi:10.1684/ecn.2015.0370

Cited by 17 publications

(16 citation statements)

References 39 publications

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“…For this reason, this study was performed. Table 1 shows that patients who participated in this study were obese, the BMI was 28.72± 4.66, and this finding was concordant with previous result 11 who reported that 41% of women with PCOS suffer from obesity. In PCOS, hyperinsulinemia and dyslipidemia are strongly associated with obesity.…”

Section: Methodssupporting

confidence: 91%

“…Women with PCOS had hyperinsulinism (17.22 vs. 8.1 µlU/ml) ( Table 1), and this result was consistent with previous results. 1,11 The explanation of this significant elevation in the serum level of insulin in women with PCOS this is mainly associated to decreased insulin clearance, IR and compensatory hyperinsulinism are the predominant metabolic defects in PCOS. However, hyperinsulinism, as well as being compensatory, can also express a condition of reduced insulin clearance.…”

Section: Methodsmentioning

confidence: 99%

“…14 It was published that, PCOS is associated with the dysfunctional production of adipokines, initiating inflammation and IR. 15 Hyperandrogen PCOS is a common endocrine/metabolic disorder in women of reproductive age, characterized by chronic anovulation and hyperandrogenism, and this facts 11,16 were consistent with the results of the current study, (Table 1) shows that there were significant elevations in the serum levels of testosterone (4.18 Vs 3.58pg/ml; 0.9±0.23 Vs 0.71±0.32) (free and total forms respectively) in patients group as compared with the control group. The explanation for hyperandrogenism that visfatin has an insulin-mimetic properties, 9 accordingly it is very well known that hyperinsulinemia can stimulate ovarian androgen biosynthesis.…”

Section: Insulin Resistancementioning

confidence: 99%

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The impact of serum visfatin, and resistin levels on insulin resistance in patients with polycystic ovary syndrome

Moustafa

Al‐Hakeim

2020

Zanco J Med Sci

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Introduction measurement used in scientific studies because it is a simple and noninvasive, and inexpensive technique. 2 The occurrence of PCOS for long term consequences type 2 diabetes mellitus, hypertension, and cardiovascular disease. 3 Many surrogate markers are needed to facilitate the estimation of IR. Many new proteins are strongly involved with PCOS physiopathology and IR, such as visfatin and resistin, but their roles are still controversial. IR and hyperinsulinemia determine hyperandrogenemia stimulating ovarian theca cells to secrete androgens and increasing LH effect on ovarian androgen production. Both androgens and insulin inhibit sex hormone binding globulin (SHBG) secretion, increasing free and bioactive androgen levels, and making Background and objective: Women with polycystic ovary syndrome serve as a model to estimate the functions of insulin resistance and chronic hyperinsulinemia on serum level of insulin resistance markers. This study aimed to determine the association of the serum visfatin, resistin levels with insulin resistance in patients with polycystic ovary syndrome, and its correlations with various parameters. Methods: This case-control study was performed at the College of Pharmacy, Hawler Medical University in the period between May 2017 and July 2018. It included 100 patients and 100 age matched healthy control group was also enrolled for comparing purposes. Results: Patients had significantly elevated serum visfatin (2.46 vs. 1.08 ng/ml), resistin (3.87 vs. 2.46ng/ml), and insulin (17.22 vs. 8.1 µlU/ml) levels than controls. They also had significant elevations in insulin resistance (2.41 vs. 1.92) and β insulin function (94.45 vs. 86.98). There was no significant variation in insulin sensitivity (88.77 vs. 92.08). Conclusion: There was an association between resistin, visfatin, and polycystic ovary syndrome-related insulin resistance. Many recent proteins are now considered as potential new markers of insulin resistance in polycystic ovary syndrome. There was a strong connection between visfatin and resistin with insulin resistance in polycystic ovary syndrome pathophysiology.

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Section: Methodssupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Insulin Resistancementioning

confidence: 99%

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The impact of serum visfatin, and resistin levels on insulin resistance in patients with polycystic ovary syndrome

Moustafa

Al‐Hakeim

2020

Zanco J Med Sci

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“…Interestingly, in a randomised placebo-controlled study involving overweight women suffering from PCOS, circulating levels of resistin were significantly decreased by the insulin-sensitising agent rosiglitazone [206]. However, although a significant correlation between plasma resistin and IR or type 2 diabetes has been reported [207], most of the studies do not confirm the existence of such an association [47,115,208,209,210] (Figure 11). In particular, Panidis et al showed that plasma resistin levels did not differ between PCOS and control normal-weight women, even though the former were more insulin-resistant.…”

Section: Adipokines and Female Reproductive Pathologiesmentioning

confidence: 99%

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models

Estienne

Bongrani

Reverchon

et al. 2019

IJMS

134

112

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It is well known that adipokines are endocrine factors that are mainly secreted by white adipose tissue. Their central role in energy metabolism is currently accepted. More recently, their involvement in fertility regulation and the development of some reproductive disorders has been suggested. Data concerning the role of leptin and adiponectin, the two most studied adipokines, in the control of the reproductive axis are consistent. In recent years, interest has grown about some novel adipokines, chemerin, visfatin, resistin and apelin, which have been found to be strongly associated with obesity and insulin-resistance. Here, we will review their expression and role in male and female reproduction in humans and animal models. According to accumulating evidence, they could regulate the secretion of GnRH (Gonadotropin-Releasing Hormone), gonadotropins and steroids. Furthermore, their expression and that of their receptors (if known), has been demonstrated in the human and animal hypothalamo-pituitary-gonadal axis. Like leptin and adiponectin, these novel adipokines could thus represent metabolic sensors that are able to regulate reproductive functions according to energy balance changes. Therefore, after investigating their role in normal fertility, we will also discuss their possible involvement in some reproductive troubles known to be associated with features of metabolic syndrome, such as polycystic ovary syndrome, gestational diabetes mellitus, preeclampsia and intra-uterine growth retardation in women, and sperm abnormalities and testicular pathologies in men.

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“…For example, AR, a nuclear transcription factor and member of the steroid receptor superfamily, is important in hyperandrogenism, which is a common syndrome of PCOS, and hyperactive AR is also considered an important marker for PCOS diagnosis ( 14 ). Insulin resistance is a key pathophysiological marker of PCOS, and it is reported that insulin resistance occurs in 50–70% of women with PCOS ( 15 ). The transcription factor, cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcriptional coactivator 2 are reported to be involved in the control of hepatic gluconeogenesis in insulin resistance ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Transcription factor-microRNA synergistic regulatory network revealing the mechanism of polycystic ovary syndrome

Liu

Huang

Liu

et al. 2016

Molecular Medicine Reports

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Polycystic ovary syndrome (PCOS) is the most common type of endocrine disorder, affecting 5–11% of women of reproductive age worldwide. Transcription factors (TFs) and microRNAs are considered to have crucial roles in the developmental process of several diseases and have synergistic regulatory actions. However, the effects of TFs and microRNAs, and the patterns of their cooperation in the synergistic regulatory network of PCOS, remain to be elucidated. The present study aimed to determine the possible mechanism of PCOS, based on a TF-microRNA synergistic regulatory network. Initially, the differentially expressed genes (DEGs) in PCOS were identified using microarray data of the GSE34526 dataset. Subsequently, the TFs and microRNAs which regulated the DEGs of PCOS were identified, and a PCOS-associated TF-microRNA synergistic regulatory network was constructed. This network included 195 DEGs, 136 TFs and 283 microRNAs, and the DEGs were regulated by TFs and microRNAs. Based on topological and functional enrichment analyses, SP1, mir-355-5p and JUN were identified as potentially crucial regulators in the development of PCOS and in characterizing the regulatory mechanism. In conclusion, the TF-microRNA synergistic regulatory network constructed in the present study provides novel insight on the molecular mechanism of PCOS in the form of synergistic regulated model.

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Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome

Cited by 17 publications

References 39 publications

The impact of serum visfatin, and resistin levels on insulin resistance in patients with polycystic ovary syndrome

The impact of serum visfatin, and resistin levels on insulin resistance in patients with polycystic ovary syndrome

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models

Transcription factor-microRNA synergistic regulatory network revealing the mechanism of polycystic ovary syndrome

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