Evaluation of Interceed(TC7)  for reduction of postoperative adhesions in rabbits

Best, Craig L.; Rittenhouse, Douglas; Vásquez, C María; Norng, Thida; Subias, E.; Sueldo, Carlos

doi:10.1016/s0015-0282(16)55333-3

Cited by 31 publications

(3 citation statements)

References 7 publications

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“…A number of agents and methods have been employed to minimize adhesion formation with varying degrees of success, including the use of corticosteroids [160], nonsteroidal anti-inflammatory drugs [161], calcium channel blockers [162], plasminogen activators [163], liquids [164,165], and more recently, ''bio-absorbable'' mechanical barriers [166][167][168][169][170][171]. There is currently no accepted standard treatment for adhesion reduction, largely because the efficacy of these techniques has been marginal or not fully investigated [164].…”

Section: Adhesion Reduction Techniquesmentioning

confidence: 99%

Peritoneal Damage: The Inflammatory Response and Clinical Implications of the Neuro‐Immuno‐Humoral Axis

et al. 2010

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Section: Adhesion Reduction Techniquesmentioning

confidence: 99%

Peritoneal Damage: The Inflammatory Response and Clinical Implications of the Neuro‐Immuno‐Humoral Axis

et al. 2010

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“…It is typically degraded in about 2 weeks following placement [29]. Many studies have been carried out involving animals and humans to evaluate the efficacy with preventing adhesions; however, the results are mixed [30][31][32]. A review of 12 RCTs concerning Interceed in gynecologic surgery reported that only four of these studies found statistically significant efficacy when compared with untreated controls.…”

Section: Oxidized Regenerated Cellulosementioning

confidence: 99%

Update on antiadhesion barriers and therapeutics in gynecological surgery

Dawodu

Baxter

Kim

2023

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of review Postoperative adhesions remain a clinical challenge to both patients and providers, as they are associated with significant complications and a high economic burden. This article provides a clinical review of currently available antiadhesive agents and promising new therapies that have advanced past animal studies. Recent findings Several agents have been investigated on their ability to reduce adhesion formation; however, there is no widely acceptable option. The few available interventions are barrier agents and while low-quality evidence suggests that they may be more effective than no treatment, there is no general agreement on their overall efficacy. There is an abundance of research on new solutions; however, their clinical efficacy is yet to be determined. Summary Although a wide range of therapeutics have been investigated, majority are halted in animal models with only a select few being studied in humans and ultimately available in the market. Many agents have shown effectiveness in reducing adhesion formation, however, that has not been translated to improvement in clinically relevant outcomes; hence the need for high-quality large randomized trials.

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“…A variety of agents and methods has been utilized to minimize adhesion formation in both experimental and clinical settings. Previous studies examining the role of corticosteroids, 3 non‐steroidal anti‐inflammatory agents, 4 calcium channel blockers, 5 plasminogen activator, 6 and mechanical barriers 7 –9 in reducing formation of adhesions have reported varying degrees of success. Although the peristalsing loops of bowel are in constant contact with one another, adhesions are virtually unknown in peritoneal cavities unexposed to the insults of inflammation, infection or surgery.…”

Section: Introductionmentioning

confidence: 99%