Evaluation of intercellular adhesion molecule-1 (ICAM-1), Tumor necrosis factor α (TNF-α), Interleukins (IL-6, IL-8) and C-reactive protein (CRP) levels in neonatal calves with presumed septicemia

Abstract

In this study; intercellular molecule-1 (ICAM-1), Tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and C-reactive protein (CRP) levels were evaluated in neonatal calves with presumed septicemia. The material of this study consisted of a total of 30 calves. Study group consisted of 20 septicemic calves and 10 clinically healthy calves and with same breed and weight and their ages were between 1 and 10 days. The statistical analysis indicated that leukocyte (WBC), red blood cell (RBC), hematocrit (Hct) hemoglobin (Hb) and mean corpuscular haemoglobin concentration (MCHC) values in neonatal calves with presumed septicemia were higher than those of the control group (P<0.05), whereas PLT values of neonatal calves with septicemia were lower than those of the control group (P<0.05). The levels of ICAM-1, TNF-α, IL-6, IL-8 and CRP values in septicemic calves were higher than those of the control group (P<0.05). As a result, it was concluded that analyzes of TNF-α, IL-6, IL-8 and particularly ICAM-1 concentrations may be considered in evaluating the severity and prognosis of patients with septicemia, as well as monitoring the efficacy of the treatment of the disease.

Biomarkers of sepsis in pigs, horses and cattle: from acute phase proteins to procalcitonin

“…In horses, CRP is considered a moderate APP that slightly increases 3–5 days after stimuli, and does not appear useful to detect sepsis because it increases similarly to non-bacterial inflammation (Yamashita et al ., 1991; Do Carmo et al ., 2015; Taylor, 2015; Zabrecky et al ., 2015). In cattle, CRP is generally not considered an APP, as no acute increases have been described in certain pathologies such as respiratory disease (Nakajima et al ., 1993; Prohl et al ., 2015), although some studies have shown mild CRP increases under conditions such as stress, intestinal obstruction, clinical mastitis, parasitic infections, or septicemia, which could make CRP useful in assessing the general status of herds (Lee et al ., 2003; Hussain et al ., 2015; Akgül et al ., 2019; Appelt et al ., 2019; Dalanezi et al ., 2020). Currently, because its measurement costs are similar to other routinely-measured methods, CRP could be measured on a routine basis to increase sensitivity to detect inflammation, especially in pigs (Tecles et al ., 2007; Rivera-Gomis et al ., 2020).…”

A Potential Biomarker Candidate for Neonatal Calf Septicemia: Presepsin: Traditional Review

“…septisemili buzağılarda CRP miktarında hafif de olsa anlamlı bir yükselme saptamışlardır. 23 Haptoglobulin ve SAA sığırlarda majör akut faz proteinleri olarak tanımlanmaktadır. LPS ile deneysel olarak oluşturulan septisemi modelinde, bu 2 akut faz proteininde de anlamlı artışlar ortaya konmuştur.…”