Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma

Hsia, Cheng Yuan; Huo, Teh Ia; Chiang, Shang-Lun; Lu, Mingzhu; Sun, Changgang; Wu, Jaw Ching; Lee, P.-C.; Chi, Chen‐Ta; Lui, Wing‐Yiu; Lee, S.-D.

doi:10.1016/j.ejso.2006.10.036

Cited by 109 publications

(105 citation statements)

References 35 publications

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“…Further shift of Th1 to Th2 responses has been also implicated in the pathogenesis of some infectious diseases, such as HIV infection, mycobacterial and protozoal diseases [25]. Additionally, recent studies have indicated the involvement of Th2 cytokines in attributing towards the risk of developing HCC as serum levels of IL-6 and IL-10 were observed to be frequently elevated in patients with HCC, further serving as complementary tumor markers in these patients [26]. Interestingly, the present investigation observed an increase in the mean levels of circulating cytokines as compared with their controls (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections

et al. 2011

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The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections. Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however, role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma.

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Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections

et al. 2011

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“…Previous study indicated that both IL-6 and IL-10 levels were elevated in HCC patients compared to normal controls, and the high levels would invariably decrease after surgical resection. [98] In addition, a high IL-10 level predicted a poor disease-free survival in patients undergoing curative surgery. [99] Hsia et al [98] found that both IL-6 and IL-10 expression were more often higher in HCC patients compared to patients in other disease categories.…”

Section: Structural Organization Of the Liver And Cytokines Potentialmentioning

confidence: 99%

“…[98] In addition, a high IL-10 level predicted a poor disease-free survival in patients undergoing curative surgery. [99] Hsia et al [98] found that both IL-6 and IL-10 expression were more often higher in HCC patients compared to patients in other disease categories.…”

Section: Structural Organization Of the Liver And Cytokines Potentialmentioning

confidence: 99%

Physiological potential of cytokines and liver damages

Mannaa¹,

Abdel-Wahhab²

2016

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Cytokines are soluble extracellular small molecular weight protein or peptide. They are produced by virtually every nucleated cell type in response to injurious stimuli to control body metabolism, infection, inflammation and tissue or neuronal damage; therefore acting as messengers between tissues and the immune system; and participating in many physiological processes through their either anti-inflammatory or pro-inflammatory characteristics. Many cytokines have multiple cellular sources and targets, as well as many natural inducers and inhibitors. In pathophysiological conditions and during the early phase of chronic liver diseases, agent like virus, bacteria, parasites, ethanol, or toxins, induce secretion of cytokines at high levels. The presence of cytokine antagonists and soluble cytokine receptors, often released in concert with their respective cytokine agonist, presents additional complexity to interpretation.

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“…HGF is produced in various organs of the body and is characterized as a multifunctional protein with various biological activities. Interestingly, although increased HGF levels in serum or tissue have been reported in patients with HCC, in other study [19], there was no significant difference of the HGF levels in patients with HCC, non-HCC tumor and chronic hepatitis group [7]. However, patients in these three groups did have a higher HGF levels as compared to normal subjects.…”

Section: Discussionmentioning

confidence: 66%

“…Of the 60 HCC patients, 56 had undergone surgical resection and had a pathological proof for HCC; the diagnosis of the remaining 4 patients was established from characteristic imaging findings in ultra sonography, computed tomography scan and hepatic angiography along with progressively elevated serum AFP levels, according to the diagnostic criteria by the European Association for the Study of the Liver [7].…”

Section: Clinical Examination and Subjectsmentioning

confidence: 99%

Evaluation of Apoptotic Marker Bcl2, CD4+, Human Hepatocyte Growth Factor and Metalloproteinase-9 as Tumor Markers for Patients with Hepatocellular Carcinoma

Youness¹,

Nemr

Oraby³

et al. 2013

Ind J Clin Biochem

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To examine the possible involvement of human B cell leukemia/lymphoma 2 (Bcl-2), CD4? cells, hepatocyte growth factor (HGF), and metalloproteinase-9 (MMP-9), as biomarkers in early diagnosis of hepatocellular carcinoma (HCC), activities of these biomarkers in serum were demonstrated by the method of Enzyme Linked Immunosorbant Assay. Two groups of subjects (60 for each), were examined in this study; healthy controls and patients with HCC. The present results declare that, significant decrease in Bcl-2 (p B 0.0001), and CD 4? (p B 0.001), while significant increase in HGF and MMP-9 (p B 0.05). These findings imply an influence of these biomarkers by the existence of hepatic carcinoma that might reflect the progression of disease and a distinction between the pathological mechanisms involved in hepatic carcinoma. Since, the serum MMP-9 activity was significantly varied between each stage of HCC. An individual profile of the present investigated parameters was detected that might serve as an easy accessing serum marker to monitor the progression of hepatic cell disorders.

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Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma

Cited by 109 publications

References 35 publications

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections

Physiological potential of cytokines and liver damages

Evaluation of Apoptotic Marker Bcl2, CD4+, Human Hepatocyte Growth Factor and Metalloproteinase-9 as Tumor Markers for Patients with Hepatocellular Carcinoma

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