Evaluation of interthalamic adhesion size as an indicator of brain atrophy in dogs with and without cognitive dysfunction

Noh, Daji; Choi, Sooyoung; Choi, Hojung; Lee, Youngwon; Lee, Kija

doi:10.1111/vru.12528

Cited by 21 publications

(33 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The apparent absence of cognitive dysfunction in the group of dogs with nearly twice the number of microhemorrhages as in the dogs with cognitive dysfunction suggests that factors other than microhemorrhages might be responsible for cognitive dysfunction. Our results support the observations of previous investigators, who also found smaller interthalamic adhesions in dogs with cognitive dysfunction than in control dogs (Hasegawa et al, 2005;Noh et al, 2017). However, decreases in interthalamic adhesion size are not specific for cognitive dysfunction and have been reported sporadically in other disorders that can cause brain atrophy (Hasegawa et al, 2005).…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Interthalamic adhesion size in aging dogs with presumptive spontaneous brain microhemorrhages: a comparative retrospective MRI study of dogs with and without evidence of canine cognitive dysfunction

Dewey

Rishniw

Johnson

et al. 2020

PeerJ

View full text Add to dashboard Cite

Objective Spontaneous brain microhemorrhages in elderly people are present to some degree in Alzheimer’s disease patients but have been linked to brain atrophy in the absence of obvious cognitive decline. Brain microhemorrhages have recently been described in older dogs, but it is unclear whether these are associated with brain atrophy. Diminution of interthalamic adhesion size-as measured on MRI or CT-has been shown to be a reliable indicator of brain atrophy in dogs with canine cognitive dysfunction (CCD) in comparison with successfully aging dogs. We hypothesized that aging dogs with brain microhemorrhages presenting for neurologic dysfunction but without obvious features of cognitive decline would have small interthalamic adhesion measurements, like dogs with CCD, compared with control dogs. The objective of this study was to compare interthalamic adhesion size between three groups of aging (>9 years) dogs: (1) neurologically impaired dogs with presumptive spontaneous brain microhemorrhages and no clinical evidence of cognitive dysfunction (2) dogs with CCD (3) dogs without clinical evidence of encephalopathy on neurologic examination (control dogs). MR images from 52 aging dogs were reviewed and measurements were obtained of interthalamic adhesion height (thickness) and mid-sagittal interthalamic adhesion area for all dogs, in addition to total brain volume. Interthalamic adhesion measurements, either absolute or normalized to total brain volume were compared between groups. Signalment (age, breed, sex), body weight, presence and number of SBMs, as well as other abnormal MRI findings were recorded for all dogs. Results All interthalamic adhesion measurement parameters were significantly (P < 0.05) different between control dogs and affected dogs. Both dogs with cognitive dysfunction (12/15; 80%) and dogs with isolated brain microhemorrhages had more microhemorrhages than control dogs (3/25; 12%). Affected dogs without cognitive dysfunction had significantly more microhemorrhages than dogs with cognitive dysfunction. In addition to signs of cognitive impairment for the CCD group, main clinical complaints for SBM and CCD dogs were referable to central vestibular dysfunction, recent-onset seizure activity, or both. Geriatric dogs with spontaneous brain microhemorrhages without cognitive dysfunction have similar MRI abnormalities as dogs with cognitive dysfunction but may represent a distinct disease category.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Dogs with cognitive dysfunction have smaller interthalamic adhesion heights than similarly aged control dogs without cognitive dysfunction (Hasegawa et al, 2005;Noh et al, 2017). This change is not considered specific for CCD but is indicative of a generalized neurodegenerative process (Hasegawa et al, 2005).…”

Section: Introductionmentioning

confidence: 98%

Interthalamic adhesion size in aging dogs with presumptive spontaneous brain microhemorrhages: a comparative retrospective MRI study of dogs with and without evidence of canine cognitive dysfunction

Dewey

Rishniw

Johnson

et al. 2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…However, the ratio did reveal a significant increase in relative lateral ventricle height with increased age. This could be due to reduction in brain volume with age a phenomenon previously reported in dogs …”

Section: Discussionmentioning

confidence: 60%

“…The method of measurement of lateral ventricle height and brain height used were subtly altered from the method used in dogs, as MRI enabled accurate assessment of both values in a single plane, however, relatively limited soft tissue detail necessitated choosing the greatest height of the lateral ventricle for measurement rather than a simple midline height. Additionally, bony rather than soft tissue landmarks were chosen for brain height to increase reliability of measurement on CT . The repeatability of the measure was confirmed by excellent interobserver reliability testing.…”

Section: Discussionmentioning

confidence: 99%

Presumed cholesterinic granulomas detected on CT in horses are associated with increased lateral ventricle height and age

Lloyd-Edwards

Willems

Beukers

et al. 2020

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Cholesterinic granulomas are mass-like lesions that form at the choroid plexus of the ventricular system. Large cholesterinic granulomas within the lateral ventricles have been reported to cause severe neurological signs. However, little data are available about their prevalence or appearance in the overall population. The objective was to report the prevalence of presumed cholesterinic granulomas on CT in a population of horses, and investigate associations between presumed cholesterinic granuloma presence, lateral ventricle size, age, and neurological signs. The study was cross sectional, CT scans of the head were assessed for presumed cholesterinic granuloma presence and size, and lateral ventricle height. Computed tomography findings and clinical information were compared using nonparametric testing. Computed tomography scans of 139 horses were included. Presumed cholesterinic granulomas were found in 22 horses (15.8%), nine were unilateral and 13 bilateral. A significant increase in prevalence was observed with age (P < .0001), with 38% of horses over 15 years old affected. The median volume of presumed cholesterinic granulomas was 242 mm 3 with a range from 51 to 2420 mm 3 . The mean lateral ventricle height was significantly increased in horses with presumed cholesterinic granulomas present (P = .004), with a median of 7.3 mm compared to 4.9 mm without. Neurological signs were not associated with presumed cholesterinic granuloma presence or lateral ventricle height. Fourth ventricle mineralizations were found in seven horses, which may represent cholesterinic granulomas. In conclusion, presumed cholesterinic granulomas occurred in a large proportion of the examined population and are associated with increased lateral ventricle dilation and advanced age.

show abstract

“…Another study found that interthalamic adhesion thickness, interthalamic adhesion thickness/brain height ratio, and lateral ventricle to brain height ratio were all significantly lower in dogs with signs of cognitive dysfunction than in dogs with no cognitive function. These metrics were validated for use in quantifying brain atrophy in patients (42). Like AD, CCD cannot be cured.…”

Section: Canine Cognitive Dysfunctionmentioning

confidence: 99%

Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases

et al. 2020

View full text Add to dashboard Cite

Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally occurring large animal models have predominantly been found in companion animals or livestock because of their emotional or economic value to modern society and, unlike mice, often recapitulate the human disease state. In particular, numerous models have been discovered in dogs and have a fundamental role in bridging proof of concept studies in mice to human clinical trials. The present article is a review that highlights current canine models of human diseases, including Alzheimer's disease, degenerative myelopathy, neuronal ceroid lipofuscinosis, globoid cell leukodystrophy, Duchenne muscular dystrophy, mucopolysaccharidosis, and fucosidosis. The goal of the review is to discuss canine and human neurodegenerative pathophysiologic similarities, introduce the animal models, and shed light on the ability of canine models to facilitate current and future treatment trials.

show abstract

Evaluation of interthalamic adhesion size as an indicator of brain atrophy in dogs with and without cognitive dysfunction

Cited by 21 publications

References 20 publications

Interthalamic adhesion size in aging dogs with presumptive spontaneous brain microhemorrhages: a comparative retrospective MRI study of dogs with and without evidence of canine cognitive dysfunction

Interthalamic adhesion size in aging dogs with presumptive spontaneous brain microhemorrhages: a comparative retrospective MRI study of dogs with and without evidence of canine cognitive dysfunction

Presumed cholesterinic granulomas detected on CT in horses are associated with increased lateral ventricle height and age

Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases

Contact Info

Product

Resources

About