Evaluation of intima-media thickness and vascular elasticity of the common carotid artery in patients with isolated systolic hypertension using ultrasound radiofrequency-data technology

Dan, Haijun; Wang, Yan; Zeng, Minxia; Luan, Yanyan; Hu, Bing

doi:10.1111/j.1475-097x.2011.01019.x

Cited by 10 publications

(19 citation statements)

References 20 publications

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“…But previous studies have indicated that the ultrasound RF-tracking technology can be used to assess the properties of the arterial wall with very high precision and reproducibility and real-time feedback on measurement quality [11], [14], [17]. A second limitation is the comparatively small number of subjects, especially older healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

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Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology

et al. 2014

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ObjectiveAtherosclerosis is a chronic and systemic disease and its developmental process involves the synergism of multiple risk factors such as hypertension, dyslipidemia, diabetes, obesity and smoking. The diagnosis of subclinical atherosclerosis is essential for strategic guidance towards suitable treatments and efficient prevention against acute cardiovascular events. This study employed ultrasound radiofrequency (RF) tracking technology to characterize human carotid arteries in vivo in terms of intima-media thickness (IMT) and artery stiffness, and evaluated the statistical correlation between carotid IMT and stiffness, and the number of risk factors for atherosclerosis.MethodsA total of 160 asymptomatic subjects were enrolled. Ultrasound RF-tracking technology was employed to acquire carotid IMT and stiffness parameters: maximum IMT (MAXIMT), RF Quality IMT (RFQIMT), distensibility coefficient (), compliance coefficient (), index, index and local pulse wave velocity (). The subjects were categorized in four groups in terms of the number of risk factors: ‘zero’, ‘single’, ‘double’, and ‘multiple’, and statistical analyses of carotid IMT and stiffness parameters were performed between these different groups.ResultsThe subjects (n = 145) with MAXIMT smaller than 1.0 mm matched the IMT criteria for non-atherosclerosis and were named as NA-subjects. Spearman’s rho correlation analysis of the whole group and the NA-subjects both showed that MAXIMT correlated positively with RFQIMT, , , and , and negatively with and (p<0.01). The analysis of covariance of NA-subjects showed significant differences between subjects with and without risk factors, and also showed significant differences between the ‘zero’, ‘single’, ‘double’, and ‘multiple’ groups.ConclusionsThe carotid IMT and stiffness parameters obtained by the ultrasound RF-tracking technology were demonstrated to possess significant statistical correlation with the number of risk factors from 160 subjects, and these anatomical and mechanical parameters may potentially be used together with the IMT criteria to support subclinical atherosclerosis diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…The system employed dedicated software RF-tracking technology to obtain RF Quality IMT (RF-QIMT) and RF Quality Arterial Stiffness (RF-QAS). Detailed description of the measurement process for RF-QIMT and RF-QAS technology can be found in [17].…”

Section: Methodsmentioning

confidence: 99%

Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology

et al. 2014

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“…Ultrasound‐based elasticity measurements can be used to investigate the biomechanical properties of tissue. A decrease in elasticity is an early sign of vascular changes that occur in major vascular diseases 30 . Clinical studies suggest that the ability of the vessel to dilate helps determines fistula success 5 , 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Several groups have used radiofrequency data and speckle‐tracking algorithms to estimate vessel wall motion and strain 23 , 30 , 31 . Another recent study used noninvasive radiofrequency data‐based common carotid artery intima‐media thickness measurements to evaluate arterial elasticity and early vascular disease in patients with isolated systolic hypertension, 30 concluding that intima‐media thickening is associated with vascular stiffness. In our study, strain estimates were calculated by a simplified image‐processing technique that could potentially be implemented in the clinical setting without disrupting the normal work flow.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Measurement of Brachial Artery Elasticity Prior to Hemodialysis Access Placement

Sorace

Robbin

Umphrey

et al. 2012

Journal of Ultrasound in Medicine

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Objectives Successful hemodialysis requires reliable vascular access that can deliver adequate blood flow. An arteriovenous fistula is preferred for access because of its longevity and low frequency of complications, but up to 60% of arteriovenous fistulas created surgically are never suitable for hemodialysis because of nonmaturation (insufficient vascular dilatation). Decreased arterial elasticity may impair dilatation, thereby affecting fistula maturation. This study evaluated the feasibility of brachial artery elasticity measurement in patients with chronic kidney disease obtained during routine preoperative mapping ultrasound (US) imaging before hemodialysis access placement and compared the measurements to those obtained in healthy volunteers. Methods Brachial artery functional US studies were collected from 75 patients undergoing routine preoperative mapping for hemodialysis access and 50 healthy volunteers. Vascular strain was calculated from the change in intima-media thickness between end systole and end diastole, and vascular stress was estimated from the pulse pressure. Assuming a linear elastic medium, the elastic modulus was estimated as the ratio of vascular stress to strain. Results Elastic modulus measurements were significantly higher in patients than in volunteers (130 versus 100 kPa; P = .01). With combined volunteer and patient data, there was a significant correlation between elasticity and systolic blood pressure (R2 = 0.23; P < .001). Elasticity was correlated with age in volunteers but not in patients (R2 = 0.14; P = .017; R2 < .001; P = .829, respectively). Conclusions This analysis of clinical arterial vessel biomechanics shows that a noninvasive US measurement can detect elastic modulus differences between patients with chronic kidney disease and healthy individuals. Future studies will correlate the elastic modulus with histologic characteristics and eventual arteriovenous fistula maturation, which may provide supplemental information on arterial biomechanical properties as a useful addition to current predictors of fistula success.

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“…Subclinical atherosclerotic alterations show their effects on the arterial wall by increasing intima‐media thickness and decreasing vascular elasticity . Carotid artery intima‐media thickness measurement represents a valid method of predicting early atherosclerosis onset and the potential cardiovascular events in the general population .…”

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confidence: 99%

Evaluation of Subclinical Atherosclerosis by Ultrasound Radiofrequency Data Technology in Patients With Familial Mediterranean Fever

Kaplanoğlu

2017

J of Ultrasound Medicine

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Evaluation of intima-media thickness and vascular elasticity of the common carotid artery in patients with isolated systolic hypertension using ultrasound radiofrequency-data technology

Abstract: US RF-data technology could be used to accurately and quantitatively evaluate increased IMT and decreased arterial elasticity of the CCA in patients with ISH compared with normal subjects.

Cited by 10 publications

References 20 publications

Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology

Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology

Ultrasound Measurement of Brachial Artery Elasticity Prior to Hemodialysis Access Placement

Evaluation of Subclinical Atherosclerosis by Ultrasound Radiofrequency Data Technology in Patients With Familial Mediterranean Fever

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