Evaluation of intramuscular ketoprofen and butorphanol as analgesics in chain dogfish (Scyliorhinus retifer)

Davis, Michelle; Mylniczenko, Natalie D.; Storms, Timothy; Raymond, F. Lucy; Dunn, J. Lawrence

doi:10.1002/zoo.20105

Cited by 32 publications

(21 citation statements)

References 35 publications

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“…Butorphanol was shown to reduce adverse post‐surgical behaviour in koi, but there is concern regarding variation in opioid sensitivity amongst different species (Harms, Kishimori, Boylan, Lewbart & Swanson 2005). An evaluation of the effect of analgesics administered to chain dogfish, Scyliorhinus retifer (Garman), found no statistically significant analgesic effect with ketoprofen or butorphanol (Davis, Mylniczenko, Storms, Raymond & Dunn 2006).…”

mentioning

confidence: 99%

Surgical removal of a gastric foreign body in a sand tiger shark, Carcharias taurus Rafinesque

Lloyd¹,

Lloyd

2011

Journal of Fish Diseases

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mentioning

confidence: 99%

Surgical removal of a gastric foreign body in a sand tiger shark, Carcharias taurus Rafinesque

Lloyd¹,

Lloyd

2011

Journal of Fish Diseases

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“…Thus, it seems prudent to explore the analgesic efficacy of aspirin in 5 dpf zebrafish. However, despite all this evidence, research on the use of NSAIDs as analgesics in fish is very limited (Davis et al, 2006;Harms et al, 2005;Mettam et al, 2011). Although the analgesic effects of aspirin have been investigated in other animals (Jablonski and Howden, 2002;Shyu and Lin, 1985), we found no studies in larval or adult fish.…”

Section: Experiments 1: Impact Of Noxious Chemicals On Larval Behaviourmentioning

confidence: 65%

Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish

López-Luna

Al-Jubouri

Al-Nuaimy

et al. 2017

Journal of Experimental Biology

105

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Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing behavioural responses. Zebrafish at 5 days postfertilization were exposed to known noxious stimuli: acetic acid (0.01%, 0.1% and 0.25%) and citric acid (0.1%, 1% and 5%). The behavioural response of each was recorded and analysed using novel tracking software that measures time spent active in 25 larvae at one time. Subsequently, the efficacy of aspirin, lidocaine, morphine and flunixin as analgesics after exposure to 0.1% acetic acid was tested. Larvae exposed to 0.1% and 0.25% acetic acid spent less time active, whereas those exposed to 0.01% acetic acid and 0.1-5% citric acid showed an increase in swimming activity. Administration of 2.5 mg l −1 aspirin, 5 mg l −1 lidocaine and 48 mg l −1 morphine prevented the behavioural changes induced by acetic acid. These results suggest that larvae respond to a noxious challenge in a similar way to adult zebrafish and other vertebrates and that the effect of nociception on activity can be ameliorated by using analgesics. Therefore, adopting larval zebrafish could represent a direct replacement of a protected adult fish with a non-protected form in pain-and nociception-related research.

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“…This is an interesting finding because butorphanol efficacy was previously evaluated and is more commonly administered empirically to fish for procedures or conditions that are considered painful. 10,21,47 …”

Section: Discussionmentioning

confidence: 99%

Comparative analgesic efficacy of morphine sulfate and butorphanol tartrate in koi (Cyprinus carpio) undergoing unilateral gonadectomy

Baker

Baker²,

Johnson³

et al. 2013

javma

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Objective To identify pain-related behaviors and assess the effects of butorphanol tartrate and morphine sulfate in koi (Cyprinus carpio) undergoing unilateral gonadectomy. Design Prospective study. Animals 90 adult male and female koi. Procedures Each fish received saline (0.9% NaCl) solution (which is physiologically compatible with fish) IM, butorphanol (10 mg/kg [4.5 mg/lb], IM), or morphine (5 mg/kg [2.3 mg/lb], IM) as an injection only (6 fish/treatment); an injection with anesthesia and surgery (12 fish/treatment); or an injection with anesthesia but without surgery (12 fish/treatment). Physiologic and behavioral data were recorded 12 hours before and at intervals after treatment. Results Compared with baseline values, the saline solution–surgery group had significantly decreased respiratory rates (at 12 to 24 hours), food consumption assessed as a percentage of floating pellets consumed (at 0 to 36 hours), and activity score (at 0 to 48 hours). Respiratory rate decreased in all butorphanol-treated fish; significant decreases were detected at fewer time points following morphine administration. In the butorphanol-surgery group, the value for food consumption initially decreased but returned to baseline values within 3 hours after treatment; food consumption did not change in the morphine-surgery group. Surgery resulted in decreased activity, regardless of treatment, with the most pronounced effect in the saline solution–surgery group. Changes in location in water column, interactive behavior, and hiding behavior were not significantly different among groups. Butorphanol and morphine administration was associated with temporary buoyancy problems and temporary bouts of excessive activity, respectively. Conclusions and Clinical Relevance Butorphanol and morphine appeared to have an analgesic effect in koi, but morphine administration caused fewer deleterious adverse effects. Food consumption appeared to be a reliable indicator of pain in koi.

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Evaluation of intramuscular ketoprofen and butorphanol as analgesics in chain dogfish (Scyliorhinus retifer)

Cited by 32 publications

References 35 publications

Surgical removal of a gastric foreign body in a sand tiger shark, Carcharias taurus Rafinesque

Surgical removal of a gastric foreign body in a sand tiger shark, Carcharias taurus Rafinesque

Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish

Comparative analgesic efficacy of morphine sulfate and butorphanol tartrate in koi (Cyprinus carpio) undergoing unilateral gonadectomy

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