Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

Teberik, Kuddusi; Eski, Mehmet Tahir; Balbay, Ege Güleç; Kaya, Murat

doi:10.12669/pjms.344.15018

Cited by 10 publications

(11 citation statements)

References 30 publications

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“…Nadarajah et al [23] did not determine any significant alteration in the IOP values in patients with OSAS compared with the control cases, but they defined decreased corneal hysteresis in OSAS, which may be another link between this disease and the development of glaucoma. Teberik et al [24] reported that there were no significant differences between the OSAS patients and control cases regarding the IOP, central corneal thickness, or RNFL values in all quadrants.…”

Section: Discussionmentioning

confidence: 97%

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Uçak

Unver

2020

Journal of Ophthalmology

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Purpose. To analyze the effects of obstructive sleep apnea syndrome (OSAS) on ocular parameters and determine the alterations in macular vasculature by optical coherence tomography-angiography (OCT-A) in patients with different stages of OSAS. Methods. All the participants underwent a full ophthalmological examination. Using the macular OCT-A scans, the retinal peripapillary capillary plexus (RPCP), foveal avascular zone (FAZ), and superficial and deep vessel densities were recorded. Results. A total of 77 patients (154 eyes) with OSAS and 27 control cases (54 eyes) were included in this prospective study. Of the OSAS patients, 27 had mild, 24 had moderate, and 26 had severe disease. The intraocular pressure (IOP) values were significantly higher in the severe OSAS group than the control cases (p=0.001). The average retinal nerve fiber layer (RNFL) thickness and the RNFL thickness of the temporal and inferior quadrants were significantly lower in the severe OSAS group compared with the control cases (p<0.05). There was a significant decrease in the mean RPCP values with a significant increase in the FAZ values of OSAS patients compared with the control group (p=0.001). Both the superficial and deep vascular densities were significantly decreased in OSAS patients, being the lowest in the severe OSAS group. Conclusions. Decreased vascular structures and increased FAZ may also be associated with the disease severity in OSAS and may be the main pathophysiological mechanisms in ocular alterations, which should be investigated in further studies.

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Section: Discussionmentioning

confidence: 97%

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Uçak

Unver

2020

Journal of Ophthalmology

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“…Kaya et al 30 reported a significant difference between the OSAS groups and the control group, whereas no significant difference was identified between AHI and corneal thickness. Teberik et al 31 reported a decreased corneal thickness in patients with OSAS than in the control group, although not to a statistically significant degree, and no significant relationship was identified with the degree of AHI. That said, the fact that patients in the control groups were not selected from among those who underwent a polysomnography may have affected the study results.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of corneal endothelium using specular microscopy in patients with obstructive sleep apnea syndrome

Songur

İntepe

Bayhan

et al. 2021

European Journal of Ophthalmology

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Purpose: In the present study we evaluate the corneal endothelium using specular microscopy in patients with obstructive sleep apnea syndrome (OSAS). Methods: The study included a total of 100 patients including 35 patients with mild OSAS, 34 patients with moderate OSAS and 31 patients with severe OSAS, and the right eyes of 30 patients as a control group. Patients were examined to exclude the possibility of ocular diseases. Cellular density in the cornea epithelium (cell/mm2), corneal thickness (µ), percentage of hexagonal cells (%) and the coefficient of variation were evaluated using a specular microscope. Results: Corneal thickness was significantly decreased in all OSAS groups when compared to the control group ( p = 0.002), while no significant difference was identified among the OSAS groups. The corneal endothelial cell density, percentage of hexagonal cells and coefficient of variation were significantly different between the OSAS groups and the control group ( p < 0.001). Conclusion: More significant impairments were noted in the corneal endothelium of the patients in the OSAS group than in the control group, and specular microscopy is in valuable in the follow-up and treatment of such patients.

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“…Teberik et al [ 33 ] conducted a prospective case–control study including 103 patients with OSA. The mean IOP values of patients with OSA were non-significantly lower than those of the control group.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, a total of 19 studies with 316,178 participants were included in this review [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. The diagnosis of OSA was based on the AHI measured using polysomnography or home sleep-apnea testing.…”

Section: Discussionmentioning

confidence: 99%

A Narrative Review of the Association between Obstructive Sleep Apnea and Glaucoma in Adults

Leggewie

Gouveris

Bahr

2022

IJMS

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Background: Obstructive sleep apnea (OSA) is a sleep disorder, primarily of the upper airway, which not only has a significant impact on quality of life but is also associated with various systemic diseases. Several ophthalmological diseases are also associated with OSA, especially glaucoma. The purpose of this review is to take a closer look at the causality and mutual influence. Methods: A systematic literature search was conducted using PubMed. A total of 19 studies with 316,178 adult participants were included. Results: Eleven of the sixteen studies concentrating on the prevalence of glaucoma in patients with OSA showed an association of both entities. One paper found a higher risk for progression of glaucoma in OSA patients. Five of the sixteen included studies failed to show a correlation between OSA and glaucoma. One study out of three surveying specific ophthalmological parameters showed an influence of OSA therapy on retinal nerve fiber layer (RNFL) thinning and vision. One study showed a rise in intraocular pressure (IOP), while two other studies showed no increase under continuous positive airway pressure (CPAP). Conclusions: Our findings suggest an association between OSA and glaucoma and, especially, between OSA and thinning of RNFL. CPAP therapy appears to be also suitable for patients with comorbid glaucoma.

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Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

Cited by 10 publications

References 30 publications

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Evaluation of corneal endothelium using specular microscopy in patients with obstructive sleep apnea syndrome

A Narrative Review of the Association between Obstructive Sleep Apnea and Glaucoma in Adults

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