Evaluation of intrapericardial cisplatin administration in cases with recurrent malignant pericardial effusion and cardiac tamponade

Tomkowski, Witold; Wı́sniewska, Joanna; Szturmowicz, Monika; Kuca, Paweł; Burakowski, Janusz; Kober, Jarosław; Fijałkowska, Anna

doi:10.1007/s00520-003-0533-x

Cited by 41 publications

(5 citation statements)

References 23 publications

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“…Improvement of local disease control and prevention of PF recurrence may be achieved by intrapericardial instillation of cytotoxic agents such as cisplatin, thiotepa, bleomycin [8,9,[13][14][15][16]. Recently, intrapericardial activity of anti--angiogenic factor -bevacizumab was reported in NPE [17].…”

Section: Discussionmentioning

confidence: 99%

“…Intrapericardial treatment tailored to the type of the tumor indicate that administration of cisplatin has been most efficient in NPE due to lung cancer [8,9,13], and intrapericardial instillation of thiotepa has been more effective in NPE due to breast cancer [18,19].…”

Section: Discussionmentioning

confidence: 99%

“…Intrapericardial cisplatin therapy was found to be an effective method of prevention of NPE recurrence in lung cancer patients [8,9]. The efficacy of such treatment in other solid tumors is poorly documented.…”

Section: Introductionmentioning

confidence: 99%

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Intrapericardial Cisplatin Combined with Oral Colchicine Resulting in Long Term Control of Malignant Pericardial Effusion in the Course of Metastatic Renal Cancer

Dybowska

Szturmowicz

Kuca

et al. 2018

Advances in Respiratory Medicine

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Background Neoplastic pericardial effusion (NPE) represents a common cause of morbidity and mortality in patient with cancer. NPE presents frequently as cardiac tamponade, requiring urgent pericardiocentesis or pericardiotomy, with subsequent pericardial fluid drainage. Despite high effectiveness of such procedures, the recurrence of effusion is noted in 30- 60% of patients. Intrapericardial therapy with cisplatin was found to be effective in NPE due to lung and breast cancer. Its role in cardiac tamponade due to renal cancer is unknown. Case presentation We presented 82-year-old man with renal cancer who was admitted to the Intensive Care Unit because of threatening pericardial tamponade due to NPE . Urgent subxiphoid pericardiotomy was performed with subsequent evacuation of 1000ml of bloody fluid. On the inner surface of the pericardium several pink nodules were found. Histological examination revealed carcinoma clarocellulare. In view of the persistent high drainage of the pericardium, intrapericardial cisplatin therapy was performed. The first day after surgery colchicine 0.5 mg/day/po was also introduced. No side effects of this treatment were observed. The patient died 12- month later due to cancer progression and cachexia. No recurrence of pericardial effusion was observed. Conclusion This is the first case study demonstrating long-term efficacy and safety of intrapericardial cisplatin combined with oral colchicine in NPE due to metastatic renal cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Intrapericardial Cisplatin Combined with Oral Colchicine Resulting in Long Term Control of Malignant Pericardial Effusion in the Course of Metastatic Renal Cancer

Dybowska

Szturmowicz

Kuca

et al. 2018

Advances in Respiratory Medicine

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“…Anthracyclines at standard doses can induce both acute and delayed AF, with the type of AF being predominantly persistent ( Ando et al, 2000 ; Kilickap et al, 2007 ; Guglin et al, 2009 ; Amioka et al, 2016 ). Cisplatin, when administered intravenously, intrapericardial, or intrathoracically, can cause acute AF in 10%–32% of patients ( Tomkowski and Filipecki, 1997 ; Tomkowski et al, 2004 ; Bischiniotis et al, 2005 ; Lara et al, 2005 ; Richards et al, 2006 ; Tilleman et al, 2009 ; Zellos et al, 2009 ). A systematic review showed that standard doses of gemcitabine, immune checkpoint inhibitors, Marfan, abiraterone acetate, and rituximab can increase the incidence of atrial fibrillation in elderly patients, those with reduced renal function, or those with hypertension ( Olivieri et al, 1998 ; Phillips et al, 2004 ; Mileshkin et al, 2005 ; Feliz et al, 2011 ; Passalia et al, 2013 ; Sharma et al, 2017 ; Hilmi et al, 2020 ; Mascolo et al, 2023 ).…”

Section: Types Of Arrhythmias Caused By Chemotherapy Drugsmentioning

confidence: 99%

A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines

Li,

Cheng,

Zhu

et al. 2024

Front. Pharmacol.

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Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of clinical practice in China, and has accumulated a wealth of medical theories and treatment formulas, which has unique advantages in the prevention and treatment of malignant diseases. Traditional Chinese medicine may reduce the arrhythmic toxicity caused by chemotherapy without affecting the anti-cancer effect. This paper mainly discussed the types and pathogenesis of secondary chemotherapeutic drug-induced arrhythmia (CDIA), and summarized the studies on Chinese medicine compounds, Chinese medicine Combination Formula and Chinese medicine injection that may be beneficial in intervention with secondary CDIA including atrial fibrillation, ventricular arrhythmia and sinus bradycardia, in order to provide reference for clinical prevention and treatment of chemotherapy-induced arrhythmias.

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“…Among patients with adenocarcinoma of the lung and pericardial tamponade who received cisplatin perfusion, 19% showed AF (Tomkowski et al, 2004 ; Richards et al, 2006 ; Tilleman et al, 2009 ; Zellos et al, 2009 ). In a recent clinic trial, carboplatin combination therapy induced AF in one of 32 patients (Illiano et al, 2000 ).…”

Section: Anticancer Drugsmentioning

confidence: 99%

Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms

Yang

Yuan

et al. 2018

Front. Pharmacol.

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Some well-established immunotherapy, radiotherapy, postoperation, anticancer drugs such as anthracyclines, antimetabolites, human epidermal growth factor receptor 2 blockers, tyrosine kinase inhibitors, alkylating agents, checkpoint inhibitors, and angiogenesis inhibitors, are significantly linked to cardiotoxicity. Cardiotoxicity is a common complication of several cancer treatments. Some studies observed complications of cardiac arrhythmia associated with the treatment of cancer, including atrial fibrillation (AF), supraventricular arrhythmias, and cardiac repolarization abnormalities. AF increases the risk of cardiovascular morbidity and mortality; it is associated with an almost doubled risk of mortality and a nearly 5-fold increase in the risk of stroke. The occurrence of AF is also usually researched in patients with advanced cancer and those undergoing active cancer treatments. During cancer treatments, the incidence rate of AF affects the prognosis of tumor treatment and challenges the treatment strategy. The present article is mainly focused on the cardiotoxicity of cancer treatments. In our review, we discuss these anticancer therapies and how they induce AF and consequently provide information on the precaution of AF during cancer treatment.

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Evaluation of intrapericardial cisplatin administration in cases with recurrent malignant pericardial effusion and cardiac tamponade

Abstract: Cisplatin administered directly into the pericardial space is a very effective and relatively safe method of treatment of recurrent malignant pericardial effusion, especially in the course of NSCLC.

Cited by 41 publications

References 23 publications

Intrapericardial Cisplatin Combined with Oral Colchicine Resulting in Long Term Control of Malignant Pericardial Effusion in the Course of Metastatic Renal Cancer

Intrapericardial Cisplatin Combined with Oral Colchicine Resulting in Long Term Control of Malignant Pericardial Effusion in the Course of Metastatic Renal Cancer

A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines

Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms

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