Evaluation of intravascular hemolysis by haptoglobin administration after prosthetic valve replacement.

Shioi, K; Nagata, Yasutoshi; Mase, Takenori; Aoyama, T.; S, Katoh; Tsuchioka, H

doi:10.1253/jcj.57.322

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“…In an acute haemolytic crisis all of the haptoglobin is usually depleted because of the one way transit of the complex with haemoglobin to the liver, where it is catabolized. Also, evaluation of intravascular haemolysis by haptoglobin administration followed by measurement has been used in surgery for prosthetic valve replacement (45). In patients exhibiting haemolysis and concurrent acute phase reaction, it should be taken into account that the decline in serum haptoglobin concentration occurs significantly faster than the serum haptoglobin increase in the acute phase (44).…”

Section: Relevance Of Haptoglobin In Clinical Medicinementioning

confidence: 99%

Review

1997

Clinical Chemistry and Laboratory Medicine

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Haptoglobin, an "acute phase" protein, has different functions, which display genetic polymorphism. The complex of haptoglobin with haemoglobin is metabolized in the heaptic reticuloendothelial system. Biosynthesis of haptoglobin occurs not only in the liver, but also in adipose tissue and in lung, providing antioxidant and antimicrobial activity. Changes in the measured concentrations of haptoglobin in serum may help to assess the disease status of patients with inflammations, infections, malignancy etc. (increases) as well as in haemolytic conditions (decreases). Haptoglobin plays a role in stimulation of angiogenesis and has highly potent cholesterolcrystallization-promoting activity. Probably the most important biological function of haptoglobin consists in the host defence responses to infection and inflammation, acting as a natural antagonist for receptor-ligand activation of the immune system.

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Section: Relevance Of Haptoglobin In Clinical Medicinementioning

confidence: 99%

Review

1997

Clinical Chemistry and Laboratory Medicine

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Evaluation of intravascular hemolysis by haptoglobin administration after prosthetic valve replacement.

Cited by 1 publication

References 2 publications

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