Evaluation of Iron Deficiency Anemia Frequency as a Risk Factor in Glaucoma

Fırat, Penpe Gül; Demirel, Ersan Ersin; Dikçi, Seyhan; Kuku, İrfan; Genç, Oğuzhan

doi:10.1155/2018/1456323

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…The current model suggests that it is the effect of chronic oxidative stress, known as ischemia-reperfusion injury [20]. However, these models do not offer a complete understanding of POAG pathogenesis as there are several factors associated with POAG, such as genetic predisposition and iron-deficiency anemia [21,22]. An initiation of POAG is still ambiguous and pathogenesis has not been clearly elucidated.…”

Section: Introductionmentioning

confidence: 99%

Microbial dysbiosis and microbiota–gut–retina axis: The lesson from brain neurodegenerative diseases to primary open-angle glaucoma pathogenesis of autoimmunity

Chaiwiang

Poyomtip

2019

AMicr

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In recent years, microbiota-associated neurodegenerative diseases have been exploited and provided new insight into disease pathogenesis. However, primary open-angle glaucoma (POAG), known as a complex neurodegenerative disease resulting from retinal ganglion cell death and optic nerve damage, can cause irreversible blindness and visual field loss. POAG, which shares several similarities with Parkinson’s disease (PD) and Alzheimer’s disease (AD), has limited studies and slow progression in the understanding of pathogenesis when compared to PD and AD. In this review, we summarized the current knowledge of POAG and commensal microbiota, combined with several lines of evidence in PD and AD to propose a possible hypothesis for POAG pathogenesis: microorganisms cause glaucoma via gut–retina axis, resulting in autoantibodies and autoreactive T cells that lead to autoimmunity. Furthermore, dual-hit hypothesis, an example of a commensal pathogen that causes PD, was partially exported in POAG. Finally, future perspectives are suggested to expand understanding of POAG.

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Section: Introductionmentioning

confidence: 99%

Microbial dysbiosis and microbiota–gut–retina axis: The lesson from brain neurodegenerative diseases to primary open-angle glaucoma pathogenesis of autoimmunity

Chaiwiang

Poyomtip

2019

AMicr

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“…Moreover, the peripapillary RNFL in the temporal quadrant was thinner in patients with vitamin B12 deficiency than in healthy controls 37 . In contrast, higher MCH was more frequently observed in glaucoma patients with a longer duration than a shorter duration of disease 38 . The present study did not evaluate serum vitamin B12 / B9 or homocysteine concentrations.…”

Section: Discussionmentioning

confidence: 66%

Systemic factors associated with 10-year glaucoma progression in South Korean population: a single center study based on electronic medical records

Yoon

Kim

Lee

et al. 2023

Sci Rep

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Glaucoma is a multifactorial disease where various systemic features are involved in the progression of the disease. Based on initial systemic profiles in electronic medical records, this study aimed to develop a model predicting factors of long-term rapid retinal nerve fiber layer (RNFL) thinning over 5 years in 505 patients with primary open-angle glaucoma. Eyes with faster or slower RNFL thinning were stratified using a decision tree model, and systemic and ophthalmic data were incorporated into the models based on random forest and permutation methods, with the models interpreted by Shapley additive explanation plots (SHAP). According to the decision tree, a higher lymphocyte ratio (> 34.65%) was the most important systemic variable discriminating faster or slower RNFL thinning. Higher mean corpuscular hemoglobin (> 32.05 pg) and alkaline phosphatase (> 88.0 IU/L) concentrations were distinguishing factors in the eyes with lymphocyte ratios > 34.65% and < 34.65%, respectively. SHAP demonstrated larger baseline RNFL thickness, greater fluctuation of intraocular pressure (IOP), and higher maximum IOP as the strongest ophthalmic factors, while higher lymphocyte ratio and higher platelet count as the strongest systemic factors associated with faster RNFL thinning. Machine learning-based modeling identified several systemic factors as well as previously acknowledged ophthalmic risk factors associated with long-term rapid RNFL thinning.

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“…34 In contrast, higher MCH was more frequently observed in glaucoma patients with longer than shorter duration of disease. 35 The present study did not evaluate serum vitamin B12 / B9 or homocysteine concentrations. Thus, the effect of any inter-relationships among MCH, vitamin B and homocysteine on glaucomatous RGC damage is not conclusive.…”

Section: Discussionmentioning

confidence: 81%

Systemic Factors Associated with Long-Term Glaucoma Progression – 10-year follow-up results based on electronic medical records

Yoon

Lee

Kim

et al. 2022

Preprint

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Glaucoma is a multifactorial disease where various systemic features are involved in the progression of the disease. Based on initial systemic profiles in electronic medical records (EMRs), this study aimed to develop a model predicting factors of long-term rapid retinal nerve fiber layer (RNFL) thinning over 5 years in 505 patients with primary open-angle glaucoma. Eyes with faster or slower RNFL thinning were stratified using a decision-tree model, and systemic and ophthalmic data were incorporated into the models based on random forest and permutation methods, with the models interpreted by Shapley additive explanation plots (SHAP). According to decision tree, higher lymphocyte ratio (> 34.65%) was the most important systemic variable discriminating faster or slower RNFL thinning. Higher mean corpuscular hemoglobin (> 32.05 pg) and alkaline phosphatase (> 88.0 IU/L) concentrations were distinguishing factors in the eyes with lymphocyte ratios > 34.65% and < 34.65%, respectively. SHAP demonstrated larger baseline RNFL thickness, greater fluctuation of intraocular pressure (IOP), and higher maximum IOP as strongest ophthalmic factors, while higher lymphocyte ratio and higher platelet counts as strongest systemic factors associated with faster RNFL thinning. Machine learning-based modeling identified several systemic factors as well as previously acknowledged ophthalmic risk factors associated with long-term rapid RNFL thinning.

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Evaluation of Iron Deficiency Anemia Frequency as a Risk Factor in Glaucoma

Cited by 10 publications

References 12 publications

Microbial dysbiosis and microbiota–gut–retina axis: The lesson from brain neurodegenerative diseases to primary open-angle glaucoma pathogenesis of autoimmunity

Microbial dysbiosis and microbiota–gut–retina axis: The lesson from brain neurodegenerative diseases to primary open-angle glaucoma pathogenesis of autoimmunity

Systemic factors associated with 10-year glaucoma progression in South Korean population: a single center study based on electronic medical records

Systemic Factors Associated with Long-Term Glaucoma Progression – 10-year follow-up results based on electronic medical records

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