Evaluation Of Iron Overload Approach in Thalassemia Patients at The Thalassemia Center

Abstract

Background: Thalassemia is a genetic blood disorder as a result of a defect in the genes responsible for the production of globin chains in hemoglobin, which is responsible for transporting oxygen to the cells of the body. Iron buildup is common in thalassemia patients as a result of frequent blood transfusions or because of the disease itself. The objectives of this research depend on the approach of iron overload in thalassemia patients, its causes and the resulting complications. Methods: A cross-sectional study was conducted in July 2022 by collecting data for thalassemia patients at the Damascus University Center, and work was done to convert this information into statistical tables and graphs in order to obtain the required objectives of this research. Results: By studying and comparing the serum ferritin values and following up the iron chelates used in thalassemia patients, these inferential statistics were reached: An increase in serum ferritin values in 70.6% of thalassemia patients while taking iron chelates. After discussing the reasons with the Thalassemia Center doctors supervising these cases, it was concluded that the reasons for the increase are due to: Non-compliance and lack of commitment with iron chelates as a result of its side effects such as nausea or vomiting, flatulence and abdominal pain, constipation or diarrhea, Material costs, Neglecting to take medication (either disregard for medical importance or as a result of being busy with work).We note from the cases of the 29.4% of patients whose ferritin values decreased that: 50% of cases were treated with the combination of deferiprone with another drug, and this indicates its effectiveness more than others.