This study was conducted to investigate the relationship between results of a salivary buffer test (CAT21 Buf Test) and caries status in 507 preschool children, who were 4-6 years old in Ulaanbaatar City, Mongolia. The prevalence of caries in the preschool children was 96.1%, and the mean deft and d teeth were 8.1 and 7.2, respectively. The mean CAT21 Buf Test score was 53.3% for low risk (high buffer capacity) and 46.7% for high risk (low buffer capacity). When salivary buffer score was divided into two groups (high risk, low risk), mean deft differed a significantly between the two groups (ANOVA PϽ0.001). The high risk group had a mean deft higher than that of the low risk group. These results suggest that the CAT21 Buf Test is useful for clinical application in children. Furthermore, when the CAT21 Buf Test score was higher, a higher correlation was shown with caries status. organism is compelled to react against them. The most effective reaction is neutralization of the acids by saliva buffers, in much the same way that the organism protects itself against internal pH variations by blood buffering. The relationship between buffer capacity and caries activity has been of interest to many researchers 21-23). Our knowledge of the functions of individual bacterial and salivary constituents and their interactions has increased enormously in recent years 24-26). We now have a better understanding of their diagnostic importance in the determination of caries activity 27,28). Salivary diagnostics is now entering the realm of modern dentistry. The aim of the present study was to investigate the relationship between the results of the CAT21 Buf Test and caries status in Mongolian preschool children. Materials and methods Subjects of study Five hundred seven preschool children aged 4-6