Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients

Cruz, Sylvia Heloisa Arantes; Nadal, Sidney Roberto; Nadal, Carmen Ruth Manzione; Calore, Edenilson Eduardo

doi:10.1590/s0102-86502012001000009

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…This can be explained by the limited sample size effect. Regarding the specific patient group evaluated in the present study, some authors (19,20) have suggested that HIV infection may be an independent factor, decreasing the density of LCs even in patients with normal CD4+ T cell counts and undetectable viral load. In view of these findings, it is possible that the development of neoplasias and opportunistic infections in HIV-positive patients may be related to HIV infection even with the apparent immunological reestablishment achieved by the success of modern antiretroviral therapies.…”

Section: Discussionmentioning

confidence: 84%

“…Furthermore, LCs migration inhibition caused by tumor-derived factors prevents LCs from promoting antitumoral immunity (15)(16)(17). Previous studies have shown the low density of LCs in squamous cell carcinoma (SCC) of the skin (18), uterine cervix (19), and anal mucosa (20). Although the relationship among CD4+ T (T helper cells) cell counts, HIV viral load, and LCs density remains unclear (21), these studies suggest that immunological changes associated with HIV infection are predisposing factors to the development of SCC.…”

Section: Introductionmentioning

confidence: 99%

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Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients

Fernandes

Heerden²,

Ribeiro³

et al. 2020

Med Oral

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Background: Although new digital pathology tools have improved the positive cell quantification, there is a heterogeneity of the quantification methods in the literature. The aim of this study was to evaluate and propose a novel dendritic cells quantification method in squamous cell carcinoma comparing it with a conventional quantification method. Material and Methods: Twenty-six squamous cell carcinomas HIV-positive cases affecting the oropharynx, lips and oral cavity were selected. Immunohistochemistry for CD1a, CD83, and CD207 was performed. The immunohistochemical stains were evaluated by automated examination using a positive pixel count algorithm. A conventional quantification method (unspecific area method; UA) and a novel method (specific area method; SA) were performed obtaining the corresponding density of positive dendritic cells for the intratumoral and peritumoral regions. The Mann-Whitney U test was used to verify the influence of the quantification methods on the

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients

Fernandes

Heerden²,

Ribeiro³

et al. 2020

Med Oral

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show abstract

“…In addition, they are eliminated from the body through the action of the immune system; they may be of subclinical and/or transitory nature. 18,20 Some of them may be latent; however, they may be reactivated and lead to the development of benign clinical lesions such as anogenital warts or intraepithelial lesions. These lesions may regress or persist and develop into anal cancer.…”

Section: Discussionmentioning

confidence: 99%

Screening anal cancer in women living with HIV/AIDS

Diefenthäler

Zanella

Coser

2018

Journal of Coloproctology

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Aim Addressing the main methodologies published in the scientific literature and used to screen anal cancer in women living with HIV/AIDS. Methodology The current study is an integrative literature review applied to articles published between 2013 and 2017 in databases such as PUBMED, EBSCO and LILACS. Results Eight studies were selected to compose the current review after the inclusion and exclusion criteria were applied. All the articles had evidence level IV. Anal cytology and the DNA-HPV test were the methodologies prevailing in the studies. The number of participants in the studies ranged from 35 to 863, and all the studies involved women living with HIV/AIDS. The aim of most of the herein reviewed studies was to assess the prevalence of anal cytologic changes or HPV infection in women living with HIV/AIDS (WLHA). Conclusion Studies have pointed out that there is concern about high anal cancer and anal HPV infection rates. They also highlighted the importance of the screening procedure for anal cancer prevention through cytology associated, or not, with molecular HPV detection methods.

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“…HIV infection has changed the epidemiological profile of anal squamous cell carcinoma (ASCC), and the rate is at least twice as high in HIV-positive as in HIV-negative individuals [3,4]. Previously, ASCC was evident in elderly female patients, whereas nowadays young male patients with this cancer are seen [5].…”

Section: Introductionmentioning

confidence: 99%

High-Risk HPV DNA Test for Screening Anal Lesions in HIV-Positive and Negative Patients

Cruzand¹

2014

J AIDS Clin Res

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The high incidence of anal dysplasia is related to many factors. The infections caused by HPV and HIV seem to be determinants of the following anal Pap smear changes: atypical squamous cells of undetermined significance (ASCUS), low-grade anal intraepithelial neoplasia (LAIN) and high-grade anal intraepithelial neoplasia (HAIN). Highrisk HPV infection is confirmed by the HPV DNA test, using hybrid capture technology. Screening for anal lesions should be complemented with the anal Pap smear protocol and high-resolution anoscopy. The aim of this study was to evaluate the influence of the high-risk HPV DNA test on screening for anal lesions. We evaluated 70 HIV-positive and negative patients who had previously had anal intercourse, at CRT/AIDS São Paulo from January 2013 to December 2013. All of the patients underwent the high-risk HPV DNA test, anal Pap smear protocol and highresolution anoscopy. The anal lesions were treated with 90% trichloroacetic acid (TCA) and 5% imiquimod for 12 weeks. The statistical analysis was performed using hypothesis tests on proportions and the significance level was set at less than 5%. 31 HIV-positive male patients, 19 HIV-negative male patients and 20 HIV-negative female patients were evaluated. 28 HIV-positive patients were positive for the high-risk HPV DNA test and 29 patients were positive for the high-risk HPV DNA test and had anal dysplasia. Our conclusion is that it was more common for HIVpositive patients to be infected with oncogenic HPV and the oncogenic HPV was more frequent in patients with anal dysplasia.

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Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients

Cited by 3 publications

References 39 publications

Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients

Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients

Screening anal cancer in women living with HIV/AIDS

High-Risk HPV DNA Test for Screening Anal Lesions in HIV-Positive and Negative Patients

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