Provision of suitable technique for saline tilapia seed is required since demand of these species increased continuously. Most saline tilapia seed rely on sourcing freshwater fingerling and further acclimatized in brackishwater ponds. The study aimed to evaluate the effects of various fry densities on seed production parameters of tilapia under high salinity-biofloc system. Three fry densities being tested and cultured under biofloc technology (BFT) at salinity level above 20 ppt, such as: A (BFT 2.5 fry L−), B (BFT 5.0 fry L−), C (BFT 7.5 fry L−) and one treatment as control, D (Non-BFT 2.5 fry L−). The experimental set-up was completely random design and triplicated replications. Animals test were fed two times a day of 32% crude protein content and it was lasted for three weeks. Results from the experiment shown that treatment A (BFT 2.5 fry L−) performed best in term of biomass (18.00±3.61g), survival (98.00±2.00%), SGR (20.72±0.20% d−), FCR (1.72±0.38) and CF (1.59±0.17). An increasing stocking density up 7.5 fry L− will reduced survival rate, final individual weight and increased FCR. It can be concluded that production of tilapia seed at a density of 2.5 fry L− under BFT conditions performed healthy seed and best production parameters even reared at higher salinity.