Evaluation of Latex Agglutination Test for Alpha-Fetoprotein in Diagnosing Rupture of Fetal Membranes

Watanabe, Takashi; Minakami, Hisanori; Itoi, Hideo; Sato, Ikuo; Sakata, Yoichi; Tamada, T

doi:10.1159/000292368

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…The reported sensitivity and specificity values for the nitrazine swab are 91% and 73%, respectively. [8][9][10] Thus, the goal of the study was to show that the TPL would demonstrate ! 91% sensitivity and !…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of a Novel Home-Based Testing Device for the Detection of Rupture of Membranes

Bornstein

Ohel²,

Sorokin

et al. 2008

Amer J Perinatol

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We evaluated the ability of a testing panty liner (TPL) embedded with a pH/ammonia indicator polymer to differentiate amniotic fluid leakage from urine. A multicenter, open-label study in which 339 pregnant women (age 18 to 45 years, minimum 16 weeks' gestation, presenting with unexplained vaginal wetness) were enrolled. The TPL was worn and the results read by the subject and a health care provider (HCP) who was blinded to the subject's reading. Results were compared with the standard clinical diagnosis, as determined by direct visualization of vaginal pooling, crystallization (ferning), and nitrazine tests, performed by a second blinded HCP. Subject experience with the test was assessed with a brief questionnaire. The TPL accurately detected 154 of the 161 subjects found to have amniotic fluid leakage by the standard diagnosis; thus, the sensitivity of the TPL was 95.65%. The specificity was 84.46% (% true negative readings), as the TPL demonstrated a negative result for 125 of the 148 subjects whose clinical diagnosis was negative for amniotic fluid leakage. The overall agreement between the TPL readings of the clinician and that of the subject was 97.40%. The TPL is a reliable test to determine the presence of amniotic fluid leakage.

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Section: Methodsmentioning

confidence: 99%

Effectiveness of a Novel Home-Based Testing Device for the Detection of Rupture of Membranes

Bornstein

Ohel²,

Sorokin

et al. 2008

Amer J Perinatol

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“…The scan date was used if date of last menstruation was uncertain, or if there was a discrepancy of more than 14 days between the two estimates. The presence of PROM was determined by measuring the alpha-fetoprotein level in vaginal fluid (14). Preeclampsia was defined as a systolic or diastolic blood pressure Ø140 or Ø90 mmHg, respectively, on two occasions recorded 24 hours apart, associated with the onset of proteinuria in a patient who had been normotensive during the first 20 weeks of gestation.…”

Section: Methodsmentioning

confidence: 99%

Influence of chorioamnionitis on survival and morbidity in singletons live-born at <32 weeks of gestation

Kosuge¹,

Ohkuchi²,

Minakami³

et al. 2000

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“…Well-known examples of methods with poor performance in unknown cases and whose role was limited to that of a supportive test rather than a confirmatory one are the fern test [10,48] and the fetal fibronectin (fFN) test [15,22] .…”

Section: Introductionmentioning

confidence: 99%

The diagnosis of rupture of fetal membranes (ROM): a meta-analysis

Ramsauer

Vidaeff

Hösli

et al. 2012

Journal of Perinatal Medicine

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Aim: The aim of this study was to compare the performance of tests based on the detection of insulin-like growth factor binding protein 1 (IGFBP-1) and placental α -microglobulin-1 (PAMG-1) in diagnosing rupture of fetal membranes (ROM) across different patient populations. Methods: A meta-analysis was conducted on prospective observational or cohort studies investigating ROM tests based on the detection of IGFBP-1 and PAMG-1 meeting the following criteria: (1) performance metrics calculated by comparing results to an adequate reference method; (2) sensitivity thresholds of the investigated tests matching those of the currently available tests; (3) study population, as a minimum, included patients between 25 and 37 weeks of gestation. Sensitivities, specificities, and diagnostic odds ratios were calculated. Results: Across all patient populations, the analyzed performance measures of the PAMG-1 test were significantly superior compared with those of the IGFBP-1 test. Of particular clinical relevance, PAMG-1 outperformed IGFBP-1 in the equivocal group, which comprised patients with uncertain rupture of membranes (sensitivity, 96.0 % vs. 73.9 % ; specificity, 98.9 % vs. 77.8 % ; respectively). Conclusions: Compared with its performance in women with known membrane status, the accuracy of the IGFBP-1 test decreases significantly when used on patients whose membrane status is unknown. In this latter clinically relevant population, the PAMG-1 test has higher accuracy than the IGFBP-1 test.

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Evaluation of Latex Agglutination Test for Alpha-Fetoprotein in Diagnosing Rupture of Fetal Membranes

Cited by 9 publications

References 7 publications

Effectiveness of a Novel Home-Based Testing Device for the Detection of Rupture of Membranes

Effectiveness of a Novel Home-Based Testing Device for the Detection of Rupture of Membranes

Influence of chorioamnionitis on survival and morbidity in singletons live-born at <32 weeks of gestation

The diagnosis of rupture of fetal membranes (ROM): a meta-analysis

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