Evaluation of lead and essential elements in whole blood during pregnancy: a cross-sectional study

Liu, K; Mao, Xuerong; Shi, Juan; Lǚ, Yingying; Liu, C

doi:10.1007/s11845-015-1339-9

Cited by 7 publications

(9 citation statements)

References 26 publications

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“…The median concentration of lead in maternal erythrocytes was 94 μg/kg, corresponding to 4 μg/dl in whole blood, assuming 99% of blood lead in the erythrocytes, 41% hematocrit, and an erythrocyte density factor of 1.06 kg/l. These levels are similar to those observed in pregnant women in China and Mexico [ 40 , 41 ] and higher than those measured in pregnant women in Canada and Germany [ 42 , 43 ].…”

Section: Discussionsupporting

confidence: 86%

Prenatal lead exposure is associated with decreased cord blood DNA methylation of the glycoprotein VI gene involved in platelet activation and thrombus formation

et al. 2015

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Early-life lead exposure impairs neurodevelopment and later exposure affects the cardiovascular system. Lead has been associated with reduced global 5-methylcytosine DNA methylation, suggesting that lead toxicity acts through epigenetic mechanisms. The objective of this study is to clarify how early-life lead exposure alters DNA methylation of specific genes, using an epigenomic approach. We measured lead concentrations in urine [gestational week (GW), 8] and erythrocytes (GW 14), using inductively coupled plasma mass spectrometry, for 127 pregnant mothers recruited in the MINIMat food and supplementation cohort in rural Bangladesh. Cord blood DNA methylation was analyzed with the Infinium HumanMethylation450K BeadChip, and top sites were validated by methylation-sensitive high-resolution melt curve analysis. Maternal urinary lead concentrations (divided into quartiles) showed significant (after adjustment for false discovery rate) inverse associations with methylation at nine CpGs. Three of these sites were in the 5′-end, including the promoter, of glycoprotein IV (GP6); cg18355337 (q = 0.029, β = −0.30), cg25818583 (q = 0.041, β = −0.18), and cg23796967 (q = 0.047, β = −0.17). The methylation in another CpG site in GP6 was close to significant (cg05374025, q = 0.057, β = − 0.23). The erythrocyte lead concentrations (divided into quartiles) were also inversely associated with CpG methylation in GP6, although this was not statistically significant after false discovery rate adjustments. Eight CpG sites in GP6 constituted a differentially methylated region in relation to urinary lead (P = 0.005, q = 0.48) and erythrocyte lead (P = 0.007, q = 0.46). In conclusion, we found that moderate prenatal lead exposure appears to epigenetically affect GP6, a key component of platelet aggregation and thrombus formation, suggesting a novel link between early lead exposure and cardiovascular disease later in life.

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Section: Discussionsupporting

confidence: 86%

Prenatal lead exposure is associated with decreased cord blood DNA methylation of the glycoprotein VI gene involved in platelet activation and thrombus formation

et al. 2015

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“…However, Ugwuja et al [ 5 ] found a negative correlation between the plasma Cu level and the newborn’s head circumference. In this study, we observed a positive association between the Cu level and the MBM/NBM ratio, which may be related to the increase in the mother’s Cu content during pregnancy [ 8 , 20 , 21 , 23 ].…”

Section: Discussionmentioning

confidence: 87%

“…The average Mg concentration in the serum was slightly lower than in non-pregnant women [19, 22]. It was confirmed that blood levels of Mg in pregnant women decreases as the pregnancy progresses [6, 15, 23]. Mg plays an important role in development during pregnancy and is utilized both for building the fetal body and metabolism in the fetus.…”

Section: Discussionmentioning

confidence: 96%

“…Furthermore, in this study, we found that Pb content in the AF is markedly higher than in MS, although the level of Pb in the AF is higher when compared with reports from other studies [ 10 ]. Liu et al observed that the serum Pb concentration increased during pregnancy [ 23 ]. The high concentration of Pb in AF in our study may be partly explained by maternal Pb exposure during pregnancy, which is readily transferred to the fetus through the placenta.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Kocyłowski

Grzesiak

Gaj

et al. 2018

Biol Trace Elem Res

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The objective of this study was to determine the concentration and the reference ranges of essential and toxic elements in amniotic fluid (AF) and maternal serum (MS) at birth. This study was conducted among 175 healthy pregnant Caucasian European women aged 18-42. AF and maternal blood samples were collected during delivery. An inductively coupled plasma mass spectrometry (ICP-MS) technique was used to determine the levels of Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe, As, Se and Sb in AF and MS. The range of reference values was calculated for all analyzed elements in the serum and AF. The mean concentrations of elements, except Pb, were generally higher in MS than in AF. Multiple regression analysis showed that the maternal/newborn body mass (MBM/NBM) ratio was a strong negative predictor (among maternal age and gravidity) of Mg concentration in amniotic fluid. In the serum, MBN/NBM ratio was a strong positive predictor of Cu concentration. Moreover, regression analysis showed that maternal age was an independent positive predictor of the Se level in maternal serum. The reference value ranges of 18 essential and toxic elements were established in AF and MS among a population of healthy pregnant Polish women at delivery. The level of Mg, Co, Cu, Ca and Se in AF and MS can be determined by maternal age and MBM/NBM ratio. These results can be useful in counseling individuals with pregnancies affected by exposure to one of the parameters under investigation.

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“…Zhang et al and Liu et al reported that the level of Ca in the first trimester is lower than that in the third trimester, possibly because the foetal demand for Ca increases compared with that in early pregnancy [20,21]. Growing evidence has shown that the prevalence of maternal Ca supplementation before and during pregnancy in China is lower than that in developed countries [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Trace Elements In Maternal Blood During Early Pregnancy And Congenital Heart Defects In Offspring

Dang

et al. 2022

Preprint

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Background: Trace elements status plays an important role in the health of pregnant women and in the healthy development of their offspring. Recent evidence showed that associate between trace element levels in mid-and late-pregnancy and congenital heart defects (CHDs) in offspring. The primary purpose of this study is to evaluate the associations between concentrations of copper (Cu), zinc (Zn), calcium (Ca), manganese (Mg), iron (Fe), lead (Pb) and cadmium (Cd) in maternal blood during early pregnancy and CHDs in offspring. Methods: This hospital-based, case–control study included 181 cases and 218 controls from Shaanxi, China. Eligible pregnant women underwent routine prenatal examinations in the hospital. Maternal elbow venous blood draws were performed during gestational weeks 11-14 and were used to detect the levels of Cu, Zn, Ca, Mg, Fe, Pb, and Cd by the atomic absorption method. Multivariable logistic regression was used to evaluate the associations of each of the seven elements with risk for overall CHDs and patent ductus arteriosus (PDA)/atrial septal defect (ASD)/ventricular septal defect (VSD) subtypes, adjusted for maternal age, parity, pregnancy complications, gestational age at birth weeks. We also conducted non-linear associations using restricted cubic spline models.Results: The median maternal blood levels of Zn, Fe, Pb and Cd of during early pregnancy in foetuses with the PDA/ASD/VSD subtypes were significantly different from those in the control group (all p < 0.001). The levels of Fe [OR, 3.684 (1.437); OR, 4.917 (1.786)] and Pb [OR, 1.026 (0.009); OR, 1.027 (0.008)] and Cd [OR, 1.643 (0.468); OR, 1.855 (0.503)], were associated with an increased risk for PDA/ASD/VSD subtypes, and that of Zn [OR, 0.944 (0.017); OR, 0.947(0.015)] was associated with a decreased risk. We observed non-linear dose–response associations between the levels of Fe, Pb, and Zn and the risk of PDA/ASD/VSD subtypes. Conclusions: This exploratory study determined that the levels of Pb during early pregnancy are associated with overall CHDs as well as ASD/VSD/PDA subtypes, however high Pb and Cd was associate with high risk of ASD/VSD/PDA subtypes, further confirming that there was is a nonlinear correlation.

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Evaluation of lead and essential elements in whole blood during pregnancy: a cross-sectional study

Cited by 7 publications

References 26 publications

Prenatal lead exposure is associated with decreased cord blood DNA methylation of the glycoprotein VI gene involved in platelet activation and thrombus formation

Prenatal lead exposure is associated with decreased cord blood DNA methylation of the glycoprotein VI gene involved in platelet activation and thrombus formation

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Correlation Between Trace Elements In Maternal Blood During Early Pregnancy And Congenital Heart Defects In Offspring

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