Evaluation of leukocyte arylsulfatase-A activity in patients with breast cancer and benign breast disease

Determination of diagnostic and prognostic values of urinary interleukin-8, tumor necrosis factor-α, and leukocyte arylsulfatase-A activity in patients with bladder cancer

“…), which catalyze the hydrolysis of aromatic sulfate esters, increase in a variety of tumor tissues (bladder, lung, gastrointestinal, breast, leukocytes) more than the corresponding healthy tissues [1][2][3][4][5]. In one of our recent studies, we found increased leukocyte AS-A activity in patients with breast cancer when compared with benign breast disease patients and healthy individuals [6]. AS's have also been implicated in the pathogenesis of bladder cancer, which is the second most frequent tumor of the urogenital tract, by releasing suspected carcinogens from their detoxified sulfated conjugates [7].…”

Aryl sulfatase from Naja nigricolis venom: Characterization and possible contribution in the pathology of snake poisoning

“…Such deposition of the highly charged molecules will have dire consequences on signal transduction across membranes. Since desulfation has been shown to increase susceptibility of mucin to degradation [3,7], asulfo-enzyme generated constituents of tendons, ligaments, and aorta will precede the deleterious activities of other enzymes present in the venom. The high physiological efficiency of the AS could thus contribute to the pathological effect of N. nigricolis.…”

“…The metabolism of sulfated compounds is controlled by aryl sulfatases (AS) and sulfotransferases [2]. Deficiency of AS and sulfo- transferase in humans is known to result into inborn errors, which manifest with several syndromes [3,4]. Also the regulation of the activity of AS, steroid sulfatase have been shown to be critical in breast cancer.…”