Evaluation of Lipocalin-2 and Vaspin Levels in In Iraqi Women with Type 2 Diabetes Mellitus

Abed, Baydaa Ahmed; Hamid, Ghada Salam

doi:10.24996/ijs.2022.63.11.3

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…Lessening of adiponectin levels has been proposed to assume a focal part in the expanded rate of T2DM and IR disorder [37][38][39][40] . In obese animal models the Adiponectin levels have reduced, which decreases insulin sensitivity and induce DMT2 start 32,[41][42] .…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum Nesfatin-1, Adiponectin, Resistin Concentration, and Obesity with Type 2 Diabetes Mellitus

Abed,

Farhan,

Dawood

2023

Baghdad Sci.J

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Diabetes mellitus caused by insulin resistance is prompted by obesity. Neuropeptide Nesfatin-1 was identified in several organs, including the central nervous system and pancreatic islet cells. Nesfatin-1 peptide appears to be involved in hypothalamic circuits that energy homeostasis and control food intake. Adiponectin is a plasma collagen-like protein produced by adipocytes that have been linked to the development of insulin resistance (IR), diabetes mellitus type 2 (DMT2), and cardiovascular disease (CVD). Resistin was first identified as an adipose tissue–specific hormone that was linked to obesity and diabetes. The aim of this study was to estimate the relationship between human serum nesfatin-1, adiponectin, resistin concentration, and obesity with T2DM. The results show a significant increase in serum neisfatin-1 and resistin levels in the obese diabetic group compared to the non-obese diabetic group. Adiponectin levels had a highly significant decrease in the obese diabetic group compared to the non-obese group and obese control group. Serum Nesfatin-1 and some variables, there was a significant positive correlation with (BMI, insulin, HOMA-IR), and serum resistin had a significant positive correlation with (BMI, WC, TG, insulin, HOMA-IR).On the other hand, there was a negative correlation between serum adiponectin and (BMI, TG, and HOMA-IR). The present results suggest that nesftin-1 may have a role in controlling food intake as well as the development of IR in obese patients.

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Section: Discussionmentioning

confidence: 99%

Relationship between serum Nesfatin-1, Adiponectin, Resistin Concentration, and Obesity with Type 2 Diabetes Mellitus

Abed,

Farhan,

Dawood

2023

Baghdad Sci.J

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“…Hyperglycemia is an indicator of type 2 diabetes mellitus (T2DM), a chronic metabolic disease. Microvascular problems such as diabetic retinopathy, diabetic nephropathy(DN) ,and neuropathy can arise from persistent hyperglycemia [35,36]. Jiang et al, identified ISM1 as an adipokine expressed in mature adipocytes with a significant function in the metabolism of fats and carbohydrates.…”

Section: Isthmin-1 and Type 2 Diabetes Mellitusmentioning

confidence: 99%

A review on the role of novel adipokine Isthmin-1 and Subfatin in human type 2 diabetes mellitus

Ahmed abed,

Othman Farhan,

Noori Salman

et al. 2023

UTJsci

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Adipokines are essential for maintaining cardiovascular and metabolic balance. The term "adipokines" refers to peptides in the pancreas, brain, vascular system, liver, immune system and muscle. adipokines regulate numbers of factors, such as energy expenditure, hunger, satiety, insulin sensitivity, and blood pressure, insulin secretion, adipogenesis and fat distribution, and that might make them play a role in future pharmacological treatment strategies for obesity and metabolic diseases. Isthmin-1 (Ism-1) is a recently discovered insulin-like adipokine that suppresses hepatic lipids. According to recent research, Ism-1 can enhance lipid metabolism and treat metabolic disorders linked to type 2 diabetic mellitus (T2DM). The primary source of the protein subfatin (SUB) is white adipose tissue. Subfatin (SUB) is expressed in these following tissues: adipose tissue, brain tissue, thymus gland, liver, activated human monocytes, spleen, omental adipose tissue, muscle, salivary glands and heart tissues. The SUB lowers insulin resistance to control glucose metabolism. Isthmian-1 is a novel biomarker for early management and diagnosis of T2DM and has a beneficial effect in glucose homeostasis and might be therapeutic for diabetes. Subfatin also plays a role in glucose metabolism and insulin sensitivity, so it has significant effect in pathogenesis and complication of diabetes.

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“…Myostatin, a secreted protein, inhibits the growth of skeletal muscle. Cells in the myotome and growing skeletal muscle express the hormone myostatin, which controls the number of muscle fibers that are ultimately produced during Adults' skeletal muscles manufacture the myostatin protein, which circulates in the blood and regulates the synthesis of new muscle fibers 5,6 . Myostatin, a potent member of the TGF-beta/bone morphogenetic protein (BMP/TGF) group of secreted proteins, inhibits the growth of skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

Studying Myostatin as a Diagnostic Indicator in Sera of Iraqi Women with Metabolic Syndrome

Assaf,

Farhan

2024

Baghdad Sci.J

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Obesity in the abdominal area, insulin resistance, hyperglycemia, dyslipidemia, and hypertension are all included as part of metabolic syndrome. Myocytes manufacture and release the myokine known as myostatin, which acts on muscle cells inhibiting cellular growth. This study aimed to compare Myostatin along with other biochemical parameters (Fasting blood sugar (FBS), cholesterol, high-density lipoprotein (HDL), triglycerides (T.G), low-density lipoprotein (LDL), and very Low-density lipoprotein (VLDL)) in sera of Iraqi with metabolic syndrome patients and healthy subjects. Eighty women were separated into two groups: group I, 40 metabolic disorders patients, and group II, 40 healthy people, which served as the control group. Myostatin levels significantly increased compared to the control group in the group with metabolic syndrome, according to the data p > 0.001. A definite cut-off value was visible on the Myostatin ROC curve (5), in the metabolic syndrome. The outcomes suggest myostatin as possible diagnostic tool for metabolic syndrome.

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Evaluation of Lipocalin-2 and Vaspin Levels in In Iraqi Women with Type 2 Diabetes Mellitus

Cited by 8 publications

References 30 publications

Relationship between serum Nesfatin-1, Adiponectin, Resistin Concentration, and Obesity with Type 2 Diabetes Mellitus

Relationship between serum Nesfatin-1, Adiponectin, Resistin Concentration, and Obesity with Type 2 Diabetes Mellitus

A review on the role of novel adipokine Isthmin-1 and Subfatin in human type 2 diabetes mellitus

Studying Myostatin as a Diagnostic Indicator in Sera of Iraqi Women with Metabolic Syndrome

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