Evaluation of lithium therapy in chronic and periodic alcoholism

Kline, Nathan S.; Wren, Joanne; Cooper, Thomas R.; Varga, Ervin; Canal, O

doi:10.1097/00000441-197407000-00002

Cited by 130 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact it has been reported that lithium can suppress amphetamine-induced stimulation in man (Flemenbaurn, 1974;van Karnrnen and Murphy, 1975) and that lithium-treatment of alcoholic patients with depression display a lowered readmission rate (Kline et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

The effect of lithium on the locomotor stimulation induced by dependence-producing drugs

Berggren

Engel

Liljequist

1981

J. Neural Transmission

View full text Add to dashboard Cite

The present study was performed to investigate how lithium affects locomotor stimulation induced by dependence-producing drugs such as amphetamine, ethanol and morphine. Acute lithium alone was found to suppress exploratory hyperactivity in mice without affecting basal locomotor activity, further supporting the contention that lithium has a neurolept-like behavioural profile. Acute lithium pretreatment suppressed locomotor stimulation in mice induced by all the dependence-producing drugs in a dose-dependent manner. Locomotor stimulation seen after amphetamine and ethanol appeared to be more suppressed by lithium than that seen after morphine. Taken together with the finding that lithium had no effect on apomorphine-clonidine-induced locomotor stimulation after elimination of presynaptic activity the present data suggest that the suppressive effect of lithium is mediated via presynaptic catecholaminergic mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of lithium on the locomotor stimulation induced by dependence-producing drugs

Berggren

Engel

Liljequist

1981

J. Neural Transmission

View full text Add to dashboard Cite

show abstract

“…Early double-blind, controlled studies appeared to indicate that lithium decreased the consumption of alcohol in depressed alcoholics (Kline et al, 1974;Merry et al, 1976). This effect did not appear to be associated with a decrease in depressive symptoms, but nondepressed alcoholics were not affected similarly.…”

Section: Effect Of Lithium On Reward Behavior In Humansmentioning

confidence: 99%

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

O’Donnell

Gould

2007

Neuroscience & Biobehavioral Reviews

121

View full text Add to dashboard Cite

For nearly as long as lithium has been in clinical use for the treatment of bipolar disorder, depression, and other conditions, investigators have attempted to characterize its effects on behaviors in rodents. Lithium consistently decreases exploratory activity, rearing, aggression, and amphetamine-induced hyperlocomotion; and it increases the sensitivity to pilocarpine-induced seizures, decreases immobility time in the forced swim test, and attenuates reserpine-induced hypolocomotion. Lithium also predictably induces conditioned taste aversion and alterations in circadian rhythms. The modulation of stereotypy, sensitization, and reward behavior are less consistent actions of the drug. These behavioral models may be relevant to human symptoms and to clinical endophenotypes. It is likely that the actions of lithium in a subset of these animal models are related to the therapeutic efficacy, as well the side effects, of the drug. We conclude with a brief discussion of various molecular mechanisms by which these lithium-sensitive behaviors may be mediated, and comment on the ways in which rat and mouse models can be used more effectively in the future to address persistent questions about the therapeutically relevant molecular actions of lithium.

show abstract

“…The suggested use of lithium salts (Li) in the treatment of alcoholic subjects (5,6) calls for an understanding of the effects of lithium on the depressant action of ethanol (ETOH). Rubidium (Rb) and cesium (Cs) salts might also be used in clinical trials to treat alcoholic patients since these alkali ions appear to have antidepressant properties (3, 7 -9 ).…”

mentioning

confidence: 99%

Alkali Metal Ions and Ethanol Narcosis in Mice

Messiha¹

1976

Pharmacology

View full text Add to dashboard Cite

The effect of an equimolar dose of LiCl, RbCl or CsCl on the depressant action of ethanol (ETOH) was studied as a function of duration of ETOH-mediated narcosis in mice. The alkali metal ions were administered acutely or semi-chronically prior to the administration of a narcotic dose of ETOH. Semi-chronic treatment with RbCl or CsCl resulted in decreased duration of ETOH-mediated narcosis, which was persistent for 5 days after discontinued administration of RbCl and CsCl. Conversely, a prolongation of ETOH-produced narcosis in Li-treated mice occurred only when ETOH was shortly administered after sub-chronic regimens of LiCl. Semi-chronic treatment with an equimolar dose of LiCl, RbCl or CsCl produced little changes in the specific activities of liver alcohol and aldehyde dehydrogenase. It is concluded that both Rb⁺ and Cs⁺ possess antidepressant properties and might be useful agents in negating the depressant action of ETOH and/or some of its toxic manifestations.

show abstract

Evaluation of lithium therapy in chronic and periodic alcoholism

Cited by 130 publications

References 0 publications

The effect of lithium on the locomotor stimulation induced by dependence-producing drugs

The effect of lithium on the locomotor stimulation induced by dependence-producing drugs

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

Alkali Metal Ions and Ethanol Narcosis in Mice

Contact Info

Product

Resources

About