Evaluation of Liver Biopsies using Histopathological Scoring System in Neonatal Hepatitis and Biliary Atresia: Correlation with Clinico-Radiological and Biochemical Parameters

Sathiah, Prasath; Basu, Debdatta; Kar, Rakhee; Jagadisan, Barath; Kumaravel, S

doi:10.7860/jcdr/2018/30685.11212

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, no preoperative diagnostic algorithm has proven 100% diagnostic accuracy for BA [3]. Consistent with many previous studies [9,[11][12][13][14][15], the current study demonstrated that NC is more frequent in male patients (37 males vs. 24 females). Based on histopathological examination of liver biopsy, 21 cases (12 males and 9 females, 34.4%) were diagnosed as BA while the remaining 40 cases (25 males and15 females, 65.6%) were diagnosed as NH.…”

Section: Discussionsupporting

confidence: 89%

Role of hepatobiliary scintigraphy with different semi-quantitative parameters along with histopathological scoring in differentiating biliary atresia from neonatal hepatitis

Mohamadien

Makboul

Galal

et al. 2021

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background Biliary atresia (BA) and neonatal hepatitis (NH) are the two major causes of neonatal cholestasis (NC). However, both conditions had entirely different therapeutic schedule and prognosis. Considering BA as a surgical emergency, it is pretty important to accurately differentiate the two entities. The aim of the study is to evaluate the diagnostic utility of hepatobiliary scintigraphy (HBS) using a semi-quantitative technique as well as 15-point histopathological scoring system in differentiating BA from NH. Results The sensitivity, specificity, and overall accuracy of HBS in the diagnosis of BA was 90.5%, 80%, and 83.6%, respectively. The median values of kidney-liver ratio (KLR), intestinal-liver ratio (ILR), and background-liver ratio (BLR) were significantly higher in patients with BA, while that of the liver-kidney ratio (LKR) was significantly lower in cases with BA. Moreover, KLR had the largest area under curve (AUC); advocates it to be the best of the semi-quantitative parameters that can predicts BA. Histopathological scoring using a cutoff point ≥ 7 was helpful in discriminating BA from NH with 85.7% sensitivity, 95% specificity and 91.8% accuracy. Conclusions HBS is a non-invasive diagnostic tool frequently used in diagnosis of BA, yet it has a relatively low specificity. To overcome this challenge, we kindly recommend the use of semi-quantitative parameters that could possibly improve the accuracy of HBS for diagnosing BA. Additionally, the use of 15-point scoring for liver biopsy was useful.

show abstract