Evaluation of Liver Chemistry Tests and Clinical Parameters in Patients with Periodontal Disease and Chronic Hepatitis C

Gheorghe, Dorin Nicolae; Rusu, Darian; Herascu, Elena; Popescu, Dora Maria; Șurlin, Petra; Rogoveanu, Ion

doi:10.37358/rc.17.6.5651

Cited by 3 publications

(6 citation statements)

References 14 publications

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“…As previously shown (27), the AT did not express significant statistical difference between the PH and P groups. No significant correlations were found between this periodontal parameter and the GCF levels of IL-1α or IL-1β.…”

Section: Resultssupporting

confidence: 64%

“…In P and PH patients, the levels of GCF cytokines expressed correlations with certain parameters of periodontal status (Table I). The results of the periodontal and hepatic evaluation have been previously published (27), expressing statistically significant differences between the P and PH groups, regarding the average number of teeth, the maximum periodontal probing depth and the AST/ALT serum levels.…”

Section: Resultsmentioning

confidence: 99%

“…The patients were selected among those who addressed the Department of Periodontology of the University of Medicine and Pharmacy of Craiova (Craiova, Romania), for periodontal complaints or pre-orthodontic treatment periodontal evaluation. Upon approval from the University's Ethical Scientific Committee, the patients who expressed their informed consent for participating in the study were subjected to an oral and periodontal examination (27). The patients were also requested to fill a medical questionnaire regarding their medical history and existing systemic diagnosis or medication.…”

Section: Methodsmentioning

confidence: 99%

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Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C

et al. 2020

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The study assessed whether the increased production of interleukin-1α (IL-1α) and interleukin-1β (IL-1β), as a result of chronic hepatic inflammation, could be the expression of the negative impact on periodontal disease. The study included chronic periodontitis patients who were systemically healthy, chronic periodontitis patients suffering from chronic hepatitis C, as well as control patients, being systemically and periodontally healthy. After periodontal examination and the assessment of certain periodontal parameters, gingival crevicular fluid was collected from all participating patients. By using the enzyme-linked immunosorbent assay method, a quantitative assessment of IL-1α and IL-1β levels was possible. The immunologic results were correlated to the clinical periodontal data. The gingival fluid levels of cytokines were higher for periodontitis patients with chronic hepatitis C than for the systemically healthy periodontitis patients (1.8-fold higher for IL-1α and 2.1-fold higher for IL-1β). In addition, the gingival fluid cytokine levels were significantly higher for the periodontal patients (with/without chronic hepatitis C) than for the control group. Positive correlations were found between gingival fluid IL-1α and IL-1β levels and certain clinical periodontal parameters or the age of the viral hepatitis C diagnosis, in periodontitis patients with chronic hepatitis C. The chronic hepatic inflammation may have an important additional negative impact on the periodontal status, as both inflammatory reactions seem to be promoted by common pro-inflammatory cytokines.

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Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C

et al. 2020

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“…The connection between HCV infection and periodontal disease is also suggested by some data that assesses its clinical impact on the manifestations of the two conditions. In a study comparing the periodontal status of patients with periodontal disease to those of patients with periodontal disease associating hepatitis C [89], the first group of patients exhibited a statistically significant larger number of remnant teeth than the second group. In addition, for the patients with periodontal disease and hepatitis C, the existing teeth were more frequently affected by periodontal pockets than the hepatitis-free patients, although not statistically significant.…”

Section: Connections Between Hcv Infection and Periodontal Statusmentioning

confidence: 99%

Periodontal Implications of Hepatitis C Infection

Șurlin¹,

Gheorghe²,

Foia³

et al. 2018

Hepatitis C - From Infection to Cure

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Periodontal tissues exhibit important vascular, lymphatic, and nervous connections with the rest of the body. Thus, periodontal inflammation caused by the interaction between the subgingival bacterial biofilm and the host immune response has an impact reaching further than the oral cavity. The concept of "periodontal medicine" reunites the bidirectional relationships that exist between periodontal disease and systemic conditions such as diabetes mellitus or cardiovascular disease. The chronic inflammation of hepatic tissues during hepatitis C virus (HCV) infection causes changes in the general homeostasis that can reverberate at periodontal level and influence periodontal inflammation. Various mechanisms such as insulin resistance or pro-inflammatory cytokines production could be the link between the two conditions. In addition, periodontal inflammation could impact HCV transmission, as HCV RNA molecules and antibodies have been found in infected patients' saliva and gingival fluid. During periodontal inflammation, gingival bleeding is frequent, and the viral molecules could enter oral fluids while being carried by peripheral blood cells. Clinical particularities that suggest the onset of periodontal disease have also been frequently observed in HCV-infected patients. The connections between periodontal disease and hepatitis C need to take into consideration by practitioners of both specialties due to their important implications on clinical manifestations and treatment strategies.

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“…In absence of epidemiological tracers for acute viral hepatitis, clinicians have to take into consideration non-alcoholic or alcoholic steatohepatitis, parasitic diseases, or a possible hepatotoxicity induced by different medication or therapy, recreational drugs, occupational exposure or herbal remedies [1,[3][4][5]. The results of standard biochemical liver functions tests cannot provide a precision diagnosis, as these changes are common in so different situations, including liver damages caused by other hepatitis viruses [6,7]. Biochemical tests for revealing liver damages are non-invasive, easily accessible, cheap, and very effective in establishing liver disease, guiding other supplementar y investigations.…”

mentioning

confidence: 99%

Biochemical Features of an Acute Viral Hepatitis A Outbreak

Cambrea¹,

Arghir²,

Rașcu³

et al. 2018

Rev. Chim.

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In developing countries, outbreaks of acute hepatitis A virus (HAV) infection have a cyclic recurrence and almost 90% of children go through disease by the age of 10. Although the evolution of HAV is rarely severe, it can cause significant economic and social losses. In order to analyze clinical and biochemical characteristics of acute HAV reported diseases in Constanta county, South Eastern Romania, during the last pediatric outbreak, all cases of hospitalized children, less than 13 years old (n=578), mostly boys with residence in urban cities, were included. Cases were divided into 295 isolated cases, mean aged 6.939 years, and 283, mean aged 6.587 years, diagnosed in different foci of the outbreak. Clinical and biochemical features of an acute HAV outbreak in the foci children��s collectivities and families consisted in mild form of disease with frequent hepatomegaly, lack of jaundice and lower levels of aminotransferases and bilirubin.

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Evaluation of Liver Chemistry Tests and Clinical Parameters in Patients with Periodontal Disease and Chronic Hepatitis C

Cited by 3 publications

References 14 publications

Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C

Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C

Periodontal Implications of Hepatitis C Infection

Biochemical Features of an Acute Viral Hepatitis A Outbreak

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