Evaluation of liver fibrosis in patients with thalassemia: The important role of hyaluronic acid

Papastamataki, Maria; Delaporta, Polyxeni; Premetis, Evangelos; Kattamis, Antonios; Ladis, Vassilios; Papassotiriou, Ioannis

doi:10.1016/j.bcmd.2010.06.002

Cited by 15 publications

(12 citation statements)

References 26 publications

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“…Furthermore, the mean fibrosis among patients with different grades of haemosiderosis seemed to remain in similar levels (fibrosis almost 3), suggesting that, although liver iron deposition progresses, the liver disease, regarding fibrosis, is stabilized. This finding was consistent with previous studies, which have suggested no progression of hepatic fibrosis or increased liver iron stores during long‐term treatment with deferiprone , and liver fibrosis to be independent from liver siderosis .…”

Section: Discussionsupporting

confidence: 93%

Liver disease in adult transfusion‐dependent beta‐thalassaemic patients: investigating the role of iron overload and chronic HCV infection

Kountouras

Tsagarakis

Fatourou

et al. 2013

Liver International

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Background: Iron overload and hepatitis-C virus (HCV) infection, have been implicated in the evolution of liver disease, in patients with transfusiondependent beta-thalassaemia major (BTM). However, the impact of these factors in late stages of liver disease in adults with BTM, has not been extensively studied. Aims: To investigate serum indices of iron overload, HCV infection and liver disease, in a cohort of 211 adult Greek patients with BTM, in relation with the findings from liver biopsies. Methods: In this cross-sectional study, 211 patients with BTM were enrolled and studied, in relation with HCV infection, ferritin, transaminases, chelation treatment and antiviral treatment. Based on 109 patients biopsied, we correlated liver fibrosis, haemosiderosis and inflammation, with serum indices and HCV status Results: Among all patients, 74.4% were anti-HCV positive (HCV+). Ferritin was positively correlated with transaminases and negatively correlated with age, while it was not significantly different among HCV+ and HCVÀ patients. Among the HCV+ patients, 55.4% reported antiviral treatment, while genotype 1 predominated. In a subfraction of 109 patients, in which liver biopsy was performed, 89% were HCV+ and 11% HCVÀ. Fibrosis was significantly correlated with age (P = 0.046), AST (P = 0.004), ALT (P = 0.044) and inflammation (P < 0.

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Section: Discussionsupporting

confidence: 93%

Liver disease in adult transfusion‐dependent beta‐thalassaemic patients: investigating the role of iron overload and chronic HCV infection

Kountouras

Tsagarakis

Fatourou

et al. 2013

Liver International

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“…It was suggested that low serum ferritin can be monitored without biopsy but liver biopsy should be performed in those with a high serum ferritin concentration [14]. Serum hyaluronic acid, type III precollagen, collagen IV, and lamini were considered as the serum markers for liver fibrosis [10,15]. We found that the degree of hepatic iron overload was correlated with both the level of serum hyaluronic acid and type III precollagen.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of Hepatic Iron Overload in Chinese Children With β-Thalassemia Major

Fang

et al. 2011

Pediatric Hematology and Oncology

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Patients with β-thalassemia major require long-term blood transfusions, resulting in hepatic iron overload. Thirty-five Chinese children with β-thalassemia major were recruited in the present studies. Hepatic iron overload was evaluated by histological grading. The relationships between hepatic iron overload and both serum biochemical markers and magnetic resonance imaging (MRI) examination were studied. The majority of the patients showed high degrees of hepatic iron overload by histological study. The degree of hepatic iron overload was correlated with serum ferritin (r = .70, P < .01), hyaluronic acid (r = .58, P = .011), and type III precollagen (r = .55, P = .035). Moreover, hepatic iron overload showed a negative correlation with liver to muscle signal intensity ratio (r = -.44, P = .012), and a positive correlation with red marrow area percentage (r = .52, P < .01). These results indicated that hepatic iron overload might be assessed by serum biochemical markers and MRI examination.

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“…There was a significant inverse relationship between serum Zn level and HA level (mean HA 244.1 ± 223.2 in patients with serum Zn ≤65 vs. 118.8 ± 117.9 ng/mL in patients with serum Zn >65 mg/dL, p<0.0001) (118). Table 5 describes studies in individuals with diseases to other organs that are also accompanied by liver involvement (119)(120)(121)(122)(123). HA levels were found to be elevated in a sample of 164 critically ill patients compared to 61 matched blood donors.…”

Section: Other Liver Disease Populationsmentioning

confidence: 96%

“…Transfusion-dependent thalassemia major (119) and pediatric β-thalassemia major (120) are described in two reports. HA was elevated, especially in patients with HCV co-morbidity in the transfusion-dependent thalassemia major sample (119). HA correlates with stages of fibrosis in pediatric β-thalassemia major patients (120).…”

Section: Other Liver Disease Populationsmentioning

confidence: 98%

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

Neuman

Cohen

Nanau

2016

Clinical Biochemistry

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Evaluation of liver fibrosis in patients with thalassemia: The important role of hyaluronic acid

Cited by 15 publications

References 26 publications

Liver disease in adult transfusion‐dependent beta‐thalassaemic patients: investigating the role of iron overload and chronic HCV infection

Liver disease in adult transfusion‐dependent beta‐thalassaemic patients: investigating the role of iron overload and chronic HCV infection

Evaluation of Hepatic Iron Overload in Chinese Children With β-Thalassemia Major

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

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