Evaluation of Liver Phantom for Testing of the Detectability Multimodal for Hepatocellular Carcinoma

Makhamrah, Osama; Ahmad, Muntaser S.; Hjouj, Mohammad

doi:10.1145/3379299.3379307

Cited by 14 publications

(7 citation statements)

References 15 publications

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“…The HCC samples were made of agarose and glycerin. This phantom was applied based on the phantom which was fabricated in a previous study [17]. In addition, the phantom was evaluated and applied through MR Imaging.…”

Section: Discussionmentioning

confidence: 99%

“…The rubber enclosure was used to prevent leakage of contrast agent (CA) from the samples when the direct contrast enhancement (DCE) was applied and to help the adjustment of HCC sample sizes through its movement inside the cylinders. All of the steps were described in detail in a previous study [17].…”

Section: Phantom Designmentioning

confidence: 99%

“…In previous studies, different materials have been used to fabricate liver phantoms for MRI such as polyacrylamide gel [10], carrageenan gel [11][12][13], agar gel [14], agarose gel [15,16], gelatin [17,18], polyurethane [19], and polyvinyl alcohol [20]. In addition, materials such as agarose-glycerol and polyurethane have been used to simulate HCC.…”

Section: Introductionmentioning

confidence: 99%

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Gelatin-Agar Liver Phantom to Simulate Typical Enhancement Patterns of Hepatocellular Carcinoma for MRI

Ahmad¹,

Suardi²,

Shukri³

et al. 2022

ARGH

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Background: Hepatocellular carcinoma (HCC) is one of the most common cause of cancer-related deaths worldwide. The objective of this study is to detect the various stages of HCC through the utilization of a dynamic liver phantom with MRI. Methods: Three liver phantoms composed of different gelatin concentrations (2.5%wt, 4.0%wt, and 5.0%wt) and fixed agar concentrations were used. The HCC samples consisted of agarose and glycerol and were of varying sizes (0.5,1.0, and 2.0cm). The chemical, mechanical, electrical, and imaging properties of the phantoms were examined. The consistency of T1 and T2 signal intensities over a six-week period was studied. In addition, dynamic contrast-enhanced MRI was used to detect the HCC samples through the Dixon sequence. Results: The gelatin concentration of 5%wt was the most stable in regard to density, exhibited the lowest average compressive strength of 0.22MPa, and had the lowest electrical conductivity over the course of a six-week period. During this time, an increase in the T1 signal intensity was observed as the gelatin concentration in the sample increased. On the contrary, the least change in T1 and T2 was noted in the first sample with the 2.5% wt of gelatin. The HCC samples simulated the typical appearance of HCC, with the minimum sample size the body coil could detect being 1cm. Conclusion: Typical Enhancement patterns of HCC were simulated under MRI.

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Section: Discussionmentioning

confidence: 99%

Section: Phantom Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gelatin-Agar Liver Phantom to Simulate Typical Enhancement Patterns of Hepatocellular Carcinoma for MRI

Ahmad¹,

Suardi²,

Shukri³

et al. 2022

ARGH

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“…There are several issues that need to be considered when using dynamic phantom. The phantom should be in a container that allows the transfer of contrast material from the arteries to the veins through the study samples, the substance of the sample should possess the appearance of HCC, the sample should interact with the contrast material, the sample should work to remove the contrast material without altering the sample structure, flexibility regarding changing the HCC samples without affecting the liver parenchyma structure, and the phantom should allow the pumping and disposal process of the contrast material by using an automatic injector and suction device [33,34].…”

Section: Dynamic Phantommentioning

confidence: 99%

Multimodal Imaging of Hepatocellular Carcinoma Using Dynamic Liver Phantom

Ahmad¹,

Makhamrah²,

Hjouj³

2022

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach

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Liver phantom is used at various medical levels, such as detecting hepatocellular carcinoma (HCC) in the early stages, training medical staff to deal with HCC by taking biopsies, developing new sequences on medical imaging devices, confirming the image quality, applying treatments to HCC, and others. All of the trials should be applied before entering the real human body. The phantom includes properties very similar to those of the human body, as well as the properties of liver cancer and how it is treated within the body through its biological form. Therefore, the present chapter aims to provide comprehensive information to consider when fabricating HCC-containing phantoms and the characteristics of those phantoms in proportion to multimodal medical imaging to aid in understanding the main target of dynamic phantom for HCC.

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“…The abundance of β-particles peaks in 131 I is 89.9% per transition [6-10].131 I decays into beta and gamma particles while treating thyroid cancer. Previous study only spoke about gamma particles that patients emitted after receiving radioactive sources 131 I but never addressed beta particles that treated thyroid carcinoma cells [11][12][13][14][15].Radioiodine 131 I ablation is a standard treatment procedure for differentiated thyroid cancer (DTC) patients. This is followed by a whole-body scan (WBS) to discover leftover thyroid tissue or metastatic illness and ablation and treatment of any confirmation [16][17][18][19][20].…”

mentioning

confidence: 99%

Statistical calculation of beta radiotherapy dose using I-131: analysis and simulation method.

Ahmad,

Mohammad

2024

J. Phys.: Conf. Ser.

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Radioiodine-131 (I-131) treats hyperthyroidism and differentiated thyroid carcinoma. In I-131, beta radiation (β−) is utilized for treatment and gamma radiation (γ) is used for diagnostic. This research sought to determine if a patient would be treated by establishing an equation for beta-thyroid cell interaction. The prospective study included 35 thyroid cancer patients receiving I-131 treatment. Beta and gamma readings were taken at different distances and sent to the statistical shop to find the coefficients of change on which the beta reaction depends and the equation that depends on it to find the beta range involved in healing. The strongest equation was R square (98.1%). To measure beta at 1 m, use the equation with a 99% association between variables and independent variables, and improve with ANOVA with a p-value of 0.00 0.05. The equation is: β_1m= -123.893+(0.947*δ) +(0.123*ε) -(0.002*π) -(2.11*Log Gamma). The discrepancy between true beta readings (mean = 1040) and the equation (mean = 1087, p-value = 0.411) is more than 0.05. That indicates the values are same. The equation that measures beta during iodine therapy has been achieved, which is the first step to improved thyroid cancer treatment.

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Evaluation of Liver Phantom for Testing of the Detectability Multimodal for Hepatocellular Carcinoma

Cited by 14 publications

References 15 publications

Gelatin-Agar Liver Phantom to Simulate Typical Enhancement Patterns of Hepatocellular Carcinoma for MRI

Gelatin-Agar Liver Phantom to Simulate Typical Enhancement Patterns of Hepatocellular Carcinoma for MRI

Multimodal Imaging of Hepatocellular Carcinoma Using Dynamic Liver Phantom

Statistical calculation of beta radiotherapy dose using I-131: analysis and simulation method.

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