Evaluation of Local Control, Survival and Pattern of Failure with Radiotherapy in Cancer of the Tongue

Padmanabhan, T. K.; Sankaranarayanan, R; Nair, Manjusha

doi:10.1159/000226802

Cited by 18 publications

(4 citation statements)

References 3 publications

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“…This rising incidence is also reflected in the population under 40 years of age who, it is estimated, make up 16e28% of all oral cancer patients seen at various institutions in India. 21 This shows an alarming rise in the incidence rate in younger people. 19 We retrospectively analyzed the pathology of lesions from young patients with OSCC and compared them to lesions from older patients in order to ascertain if there was any important exclusivity in the young population.…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical and histopathological profiles of oral squamous cell carcinoma in young Indian adults: A retrospective study

Acharya

Tayaar

2012

Journal of Dental Sciences

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Background/purpose: Substantial debate exists in the literature regarding the clinical course of young patients with oral squamous cell carcinoma (OSCC). Based on young subjects with OSCC reported at our institution, the clinicopathological features of OSCC in young patients were studied in order to determine if there were any defining characteristics in this population. Materials and methods: All cases of OSCC reported in our institution in 2005e2009 were scrutinized. Clinicopathological features of patients aged 40 years (young patients) at the time of the initial diagnosis were compared to patients aged >40 years (older patients), and there was twice the number of older than younger patients. Results: In a span of 5 years, there were 82 (24.6%) young patients ( 40years) out of 333 OSCC patients reported, and the majority were males. The bulk of OSCC patients had chewing habits of tobacco and areca nut products, and the percentage of patients using commercially available pan-tobacco products among young patients were higher compared to older patients. Exophytic growth was a common morphological presentation in OSCC patients, but young patients showed a significantly higher endophytic presentation compared to older patients. There was no significant difference between study participants when histopathological grading systems of Broder and Anneroth et al were applied. Conclusion: Exposure through behavioral risk factors was similar in young and older patients; although these had less time to act in young patients, the lesions were similar in terms of size and pathology. Demographic and clinical parameters like gender, risky habits, duration of risky Journal of Dental Sciences (2012) 7, 224e230 habits, and tumor morphology were significant predictors in the study groups. Future studies should determine the prognostic values of these parameters.

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Section: Discussionmentioning

confidence: 99%

Analysis of clinical and histopathological profiles of oral squamous cell carcinoma in young Indian adults: A retrospective study

Acharya

Tayaar

2012

Journal of Dental Sciences

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“…Only through organized efforts aimed at improving awareness, health-related behaviour, professional awareness and re-orientation, and appropriate referral will down-staging of common cancers be achieved. The proportion of radical treatment, and survival rates, would also reflect to a greater extent the clinical stages of presentation of these al., 1988;Padmanabhan et al, 1988Padmanabhan et al, , 1990. The 5-year survival rates have been found to be 46% for cancer of the larynx, 49% for cancer of the uterine cervix and 40% for breast cancer.…”

Section: Clinical Extent Of Disease At Initial Presentution (Major Camentioning

confidence: 99%

“…The proportion of radical treatment, and survival rates, would also reflect to a greater extent the clinical stages of presentation of these cancers. The 3-year survival rates in Kerala have been reported as 42% for cancer of the buccal mucosa, 36% for cancer of the tongue, and 42% for nasopharyngeal cancer (Krishnan Nair et al, 1988;Padmanabhan et al, 1988Padmanabhan et al, , 1990. The 5-year survival rates have been found to be 46% for cancer of the larynx, 49% for cancer of the uterine cervix and 40% for breast cancer.…”

Section: Clinical Extent Of Disease At Initial Presentution (Major Camentioning

confidence: 99%

Cancer control programme in india: Opportunities for implementation and evaluation

Sankaranarayanan

Nair

Mathew

et al. 1992

Intl Journal of Cancer

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Cancer is now being appreciated in India as an emerging public health problem. Approximately 600,000 new cancer cases occur in India every year, and the absolute number of new cancer patients will increase considerably, due to growth in the size of the population and an increase in the proportion of elderly persons due to improved life expectancy following control of communicable diseases. This emerging problem has received the attention of the Government of India, and some state governments within the Indian Federation have formulated National and State Cancer Control Programmes to deal with the situation. In the event of these programmes being implemented, consideration should be given now to measures of evaluation of the activities, as many of the indices, used to monitor programmes in developed countries, such as 15% reduction from peak cancer mortality, or in peak mortality from specific cancers, are not applicable in developing countries like India. Factors such as the pattern of tobacco habits in the community, knowledge, attitude and practice (KAP) patterns regarding cancer in the general population, referral practices, and the national pattern of extent of disease at presentation, gain considerable importance from the evaluation point of view. Our article mainly deals with the sources and the quality of baseline data for such factors and the realistic quantitative goals which could be set for the above factors.

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“…Excluding the smallest and the earliest tumors ( = T I ) , the regional lymph nodes should be included in surgery and radiotherapy (35,39,45,52,62,63). If radiotherapy is delivered postoperatively solely because of lymph node metastases, the primary tumor area should still be included in the target volume…”

Section: Radiotherapy Techniquesmentioning

confidence: 99%

Head and Neck Cancer

Möller

1996

Acta Oncologica

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This synthesis of the literature on radiotherapy for head and neck cancer is based on 424 scientific articles, including 3 meta-analyses, 38 randomized studies, 45 prospective studies, and 246 retrospective studies. These studies involve 79174 patients. The literature review shows that radiotherapy, either alone or in combination with surgery, plays an essential role in treating head and neck cancers. When tumors are localized, many tumor patients can be cured by radiotherapy alone and thereby maintain full organ function (1, 2). Current technical advancements in radiotherapy offer the potential for better local tumor control with lower morbidity (3). This, however, will require more sophisticated dose planning resources. To further improve treatment results for advanced tumors, other fractionation schedules, mainly hyperfractionation, should be introduced (5). This mainly increases the demands on staff resources for radiotherapy. The combination of radiotherapy and chemotherapy should be subjected to further controlled studies involving a sufficiently large number of patients (4, 5). Interstitial treatment (in the hands of experienced radiotherapists) yields good results for selected cancers. The method should be more generally accessible in Sweden. Intraoperative radiotherapy should be targeted for further study and development.

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Evaluation of Local Control, Survival and Pattern of Failure with Radiotherapy in Cancer of the Tongue

Cited by 18 publications

References 3 publications

Analysis of clinical and histopathological profiles of oral squamous cell carcinoma in young Indian adults: A retrospective study

Analysis of clinical and histopathological profiles of oral squamous cell carcinoma in young Indian adults: A retrospective study

Cancer control programme in india: Opportunities for implementation and evaluation

Head and Neck Cancer

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